Epithelial Induction in Dermatofibroma: A Role for the Epidermal Growth Factor (EGF) Receptor

Morgan, Michael B.; Howard, Heather; Everett, Mark Allen

doi:10.1097/00000372-199702000-00007

Cited by 50 publications

(32 citation statements)

References 11 publications

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“…It is believed that these epithelial changes are likely to be mesenchyme mediated, possibly related to epidermal growth factor receptor. 10 It may be possible that surgical or nonsurgical scarring can induce a distinctive subepidermal plate-like proliferation, similar to that present in the solitary or multiple variant of TFI.…”

Section: Discussionmentioning

confidence: 99%

Is Tumor of Follicular Infundibulum a Reaction to Dermal Scarring?

Lopez-Garcia

Teague

Sayyah³

et al. 2015

The American Journal of Dermatopathology

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Tumor of follicular infundibulum (TFI) is currently believed to be a benign epithelial neoplasm with follicular differentiation. It has been suggested that TFI is associated with dermal scarring, but further investigation is needed to confirm this correlation. To approach this question, a retrospective study was presented, a total of 67 cases (64 lesions) were found in a search covering cases over a 10-year period. Overall, the presence of histological dermal scarring was noted in 34 of 64 (53.13%) cases. Of the cases where TFI was an incidental finding, the presence of dermal scarring was noted in 13 of 18 (72.22%) cases. Meanwhile, of the cases where TFI was the main diagnosis, the presence of dermal scarring was noted in 12 of 34 (35.29%) cases. This suggests that TFI may, in some cases, represent an epidermal reaction pattern to dermal scarring.

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Section: Discussionmentioning

confidence: 99%

Is Tumor of Follicular Infundibulum a Reaction to Dermal Scarring?

Lopez-Garcia

Teague

Sayyah³

et al. 2015

The American Journal of Dermatopathology

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“…Dermatofibromas, including the variants, may be associated with acanthosis or hyperplasia of the overlying epidermis and hyperpigmentation of the basal layer 22 . It has been suggested that epidermal growth factor may play a role in the pathogenesis of the epidermal hyperplasia 23 .…”

Section: Discussionmentioning

confidence: 99%

A Clinical and Histopathological Study of 122 Cases of Dermatofibroma (Benign Fibrous Histiocytoma)

et al. 2011

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Background: Many variants of dermatofibromas have been described, and being aware of the variants of dermatofibromas is important to avoid misdiagnosis. Objective: We wanted to evaluate the clinical and pathologic characteristics of 122 cases of dermatofibromas. Methods: We retrospectively reviewed the medical records and 122 biopsy specimens of 92 patients who were diagnosed with dermatofibroma in the Department of Dermatology at Eulji Hospital of Eulji University between January 2000 and March 2010. Results: Nearly 80% of the cases occurred between the ages of 20 and 49 years, with an overall predominance of females. Over 70% of the lesions were found on the extremities. The most common histologic variant was a fibrocollagenous dermatofibroma (40.1%). Other variants included histiocytic (13.1%), cellular (11.5%), aneurysmal (7.4%), angiomatous (6.5%), sclerotic (6.5%), monster (4.9%), palisading (1.6%) and keloidal dermatofibromas (0.8%). There were 9 dermatofibromas (7.3%) that were the mixed type with two co-dominant histologic features. Conclusion: The results of this study are consistent with previous reports on the clinical features of dermatofibromas. However, we observed several characteristic subtypes of dermatofibroma and we compared the frequency of the histologic subtypes.

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“…17 -19 These epithelial changes probably stem from mediators released by the neoplastic fibroblasts interacting with nearby keratinocytes. 20,21 A superficial dermal grenz zone or deep lymphoid nodules may be present in some cases. 22,23 Mitoses in classic examples of DF are uncommon, but mitotic figures can be frequent in cellular and aneurysmal variants.…”

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confidence: 99%