Epithelial ion transport — Possible contribution to parasite expulsion

Baird, Alan W.; O'Malley, Kate

doi:10.1016/0169-4758(93)90180-n

Cited by 13 publications

(6 citation statements)

References 13 publications

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“…Two functional groups (GO:0071805, GO:0006813) that related to potassium ion transport were identified for FEC in the infected subset of individuals. Epithelial ion transport may contribute to parasite expulsion (Baird & O'malley, 1993), and several parasites have been shown to inhibit membrane ion transport in rat models (Kapczuk et al., 2018). No functional groups were identified for genes detected in additive GWA analyses (Table ), due to the small number of genes that were significant at an FWER of 0.2 (Table ).…”

Section: Resultsmentioning

confidence: 99%

Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge

et al. 2020

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“…For instance, increase in water and electrolyte secretions is a common feature and occurs within days or minutes after primary and secondary infections respectively with nematode parasites (Castro et al, 1979;Castro, 1989). This can be interpreted as a host physiological mechanism that assist in parasite eviction (Vallance and Collins, 1998) since secretory diarrhoea, a consequence of chloride (Cl -) secretion, may flush the GI tract of its parasites and/or produce a hostile environment to the parasites (Baird and O'Malley, 1993). Fluid and electrolyte transport is influenced by immunological reactions and, as stated above, is dramatically expressed following challenge.…”

Section: Gut Secretions and Motor Systemsmentioning

confidence: 99%

Mucosal immunity against parasitic gastrointestinal nematodes

Onah

Nawa

2000

Korean J Parasitol

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The last two decades witnessed significant advances in the efforts of immunoparasitologists to elucidate the nature and role of the host mucosal defence mechanisms against intestinal nematode parasites. Aided by recent advances in basic immunology and biotechnology with the concomitant development of well defined laboratory models of infection, immunoparasitologists have more precisely analyzed and defined the different immune effector mechanisms during the infection; resulting in great improvement in our current knowledge and understanding of protective immunity against gastrointestinal (GI) nematode parasites. Much of this current understanding comes from experimental studies in laboratory rodents, which have been used as models of livestock and human GI nematode infections. These rodent studies, which have concentrated on Heligmosomoides polygyrus, Nippostrongylus brasiliensis, Strongyloides ratti/S. venezuelensis, Trichinella spiralis and Trichuris muris infections in mice and rats, have helped in defining the types of T cell responses that regulate effector mechanisms and the effector mechanisms responsible for worm expulsion. In addition, these studies bear indications that traditionally accepted mechanisms of resistance such as eosinophilia and IgE responses may not play as important roles in protection as were previously conceived. In this review, we shall, from these rodent studies, attempt an overview of the mucosal and other effector responses against intestinal nematode parasites beginning with the indices of immune protection as a model of the protective immune responses that may occur in animals and man.

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“…We aimed to develop an optimized robust and reproducible in vitro model for assessing F. hepatica NEJ migration. Sheets of isolated intestine have been used successfully to examine pathogen entry (Baird et al 2004) as well as ion transport responses of previously sensitized mucosal sheets to specific antigen (Baird and O'Malley, 1993). We modified the structure of the horizontal diffusion chamber used in previous microbiological studies (Soni et al 2006) to our requirements for parasite studies.…”

Section: Discussionmentioning

confidence: 99%

Development of a versatile in vitro method for understanding the migration of Fasciola hepatica newly excysted juveniles

2015

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S U M M A R YFasciola hepatica is a parasitic trematode that causes serious losses to livestock producers, and also zoonotic disease. The limitations of chemotherapy for the control of fasciolosis have led to significant interest in the development of vaccines to protect cattle and sheep from infection. However, relatively few studies have concentrated on the mechanisms of invasion of the gut by newly excysted juvenile liver flukes (NEJ) and the host response triggered by this event. The aim of this work was to develop an in vitro model to study invasion by NEJ, while also reducing the requirement for challenge infections of experimental animals. Fasciola hepatica metacercariae were excysted in vitro and placed into compartments containing rat distal jejunal sheets. Variations in incubation medium, chamber size and incubation temperature were used to identify optimal conditions for NEJ migration across the gut. Histological examination showed increased migration until 120 min post-incubation. The use of RPMI, without gassing at 39°C, as the incubation medium was found to be optimal, with 40·5% of NEJ migrating after 150 min. This study describes a readily-reproducible method for studying the migration of F. hepatica NEJ within the definitive host. It will be useful for identifying potential drug and vaccine targets.

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Epithelial ion transport — Possible contribution to parasite expulsion

Cited by 13 publications

References 13 publications

Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge

Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge

Mucosal immunity against parasitic gastrointestinal nematodes

Development of a versatile in vitro method for understanding the migration of Fasciola hepatica newly excysted juveniles

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