Epithelial Lesions Suggestive of a Condylomatous Origin Found Closely Associated with Invasive Bronchial Squamous Cell Carcinomas

Syrjänen, Karí

doi:10.1159/000194265

Cited by 56 publications

(33 citation statements)

References 21 publications

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“…The possible involvement of HPV in bronchial squamous cell lesions was first suggested in 1979 by Syrjänen, who described epithelial changes in bronchial carcinomas, closely resembling those of established HPV lesions in the genital tract, e.g. exophytic and flat condylomas (9,10). However, reports concerning the HPV detection in lung tumours show several discrepancies.…”

Section: Introductionmentioning

confidence: 99%

Detection and expression of human papillomavirus oncogenes in non-small cell lung cancer

Ciotti¹,

Giuliani²,

Ambrogi³

et al. 2006

Oncol Rep

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Abstract. Human papillomavirus (HPV) has been found in lung cancer cases with variable frequency. In the present study, we analysed a series of 38 patients with non-small cell lung cancer (NSCLC) (21 paraffin-embedded archival samples and 17 fresh surgical specimens) for the presence of E6 and E7 oncogenes of HPV16, 18 and 31. Eight of the tumours were positive (21%): six HPV16, one HPV16+18, and one HPV31. The normal tissue surrounding the HPV-positive tumour was negative for the presence of the virus. Sequencing analysis of URR, of HPV16, which was the most frequently found HPV type in our cases, showed an adenosine deletion at nucleotide 7861 (E2-binding site) in four out of six patients. Sequencing of the entire E6 and E7 genes of HPV16 showed a T to G transition at nucleotide position 350 of E6, in all examined cases. This mutation is associated to the European variant of HPV16. Analysis of E6 and E7 transcripts was performed on the six fresh surgical specimens infected by HPV16. Our study showed that all of the tumours investigated, except one, contained E6 and E7 transcripts. Only in one case could we identify an unspliced form of the E6 transcript. Our results strengthen the relationship between HPV and NSCLC and support the hypothesis that HPV infection could play a role in bronchial carcinogenesis.

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Section: Introductionmentioning

confidence: 99%

Detection and expression of human papillomavirus oncogenes in non-small cell lung cancer

Ciotti¹,

Giuliani²,

Ambrogi³

et al. 2006

Oncol Rep

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“…[134,135] The possible role of HPV in lung cancer was initially proposed due to the similarities of the morphological epithelial changes detected in bronchial carcinomas with genital HPV lesions. [136,137] HPV detection in lung cancer was confirmed in 1988 [138] and the association of HPV with lung cancer was then verified by detection of HPV DNA in lung cancer samples. [139,140] However, the issue is debated and controversial studies have been reported.…”

Section: Lung Cancermentioning

confidence: 99%

The role of human papillomaviruses in cancer progression

Tulay¹,

Serakıncı²

2016

JCMT

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The importance of human papillomavirus (HPV) infection and its role in the progress of cancer have been widely evaluated. The understanding of HPV association with certain cancers, such as cervical cancer, is very well established. A big step forward in the prevention of HPV associated cancers with the use of early detection by screening strategies has also been taken. In the last decade, development of HPV vaccination has reduced the number of cases in HPV infections and infection induced cancers. In this report, we review the HPV pathogenesis and highlight the mechanism of HPV involvement in cancer development.

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“…In the lower respiratory tract, the causative role of HPV was suggested by morphological data already in 1979: cytological and histological similarities with lesions from uterine cervix condylomas were described in about 30% of bronchial epithelium next to invasive bronchial squamous cell carcinoma (16) or well differentiated squamous cell carcinoma (17,18). HPV sequences have also been demonstrated in primary lung squamous cell carcinomas (19)(20)(21).…”

Section: Introductionmentioning

confidence: 97%

Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas

1996

Lung Cancer

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Abstract. The purpose of our study was to assess the prevalence and prognostic significance of HPV infection as well as K-ras codon 12 point mutations in lung cancer. Patients diagnosed with lung carcinoma between 1988 and 1992 (N=99) were selected. HPV detection and typing was performed by PCR from paraffin-embedded tissues, while mutations in codon 12 of K-ras gene were detected using the restriction fragment length polymorphism (RFLP) analysis. The prevalence of HPV infection was 15%, while K-ras codon 12 point mutations were found in 18% of the specimens examined.

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Epithelial Lesions Suggestive of a Condylomatous Origin Found Closely Associated with Invasive Bronchial Squamous Cell Carcinomas

Cited by 56 publications

References 21 publications

Detection and expression of human papillomavirus oncogenes in non-small cell lung cancer

Detection and expression of human papillomavirus oncogenes in non-small cell lung cancer

The role of human papillomaviruses in cancer progression

Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas

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