Epithelial membrane antigen and DOG1 expression in minor salivary gland tumours

Andrade, Evelyne Pedroza de; Teixeira, Lucas Novaes; Montalli, Victor Ângelo Martins; Garcia, Flávio De Melo; Passador-Santos, Fabrício; Soares, Andresa Borges; Araújo, Vera Cavalcanti de

doi:10.1016/j.anndiagpath.2019.151408

Cited by 8 publications

(10 citation statements)

References 15 publications

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“…In our cases, immunostaining revealed that the tumor was positive for CK19, S-100, vimentin, mammaglobin, GCDFP15, GATA3, and MUC4. These markers have been reported to be useful for differentiating SC from other salivary gland tumors [4,[12][13][14][15][16]. The results were consistent with the ndings frequently observed in the previously reported cases of SC, aiding in differentiation (Tables 1 and 3).…”

Section: Casesupporting

confidence: 91%

“…Immunohistochemistry showed that the tumor was positive for cytokeratin 19 (CK19), S-100, vimentin, mammagloblin, gross cystic disease uid protein 15 (GCDFP15), and GATA3. These ndings are consistent with the immunostaining ndings frequently observed in SC [4,[12][13][14][15]. The MIB-1 index, which is indicative of tumor cell proliferative activity, was 3% (Fig.…”

Section: Case Presentation Casesupporting

confidence: 91%

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Diagnosis and Treatment of Secretory Carcinoma of the Oral Cavity: Report of Two Cases and Pooled Analysis of the Recent Literature

Ogawa¹,

Yokoo²,

Yamaguchi³

et al. 2021

Preprint

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Background: Secretory carcinoma (SC) is a malignancy of the salivary glands, which is similar to SC of the breast in terms of its association with neurotrophic tyrosine receptor kinase (NTRK) fusion-positive gene. SC is a recently described salivary gland tumor, and there are few reports describing oral minor salivary gland-derived SC. We reported two cases of SC in the oral cavity and reviewed the literature.Case presentation: The patients included a 65-year-old Japanese woman presented with a mass of the upper lip and an 84-year-old Japanese man presented with a mass on the buccal mucosa, respectively. Diagnosis was based on histomorphological and immunohistochemical findings and identification of a specific translocation of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 (ETV6-NTRK3) gene fusion. Case 1 was finally diagnosed using reverse transcription-polymerase chain reaction using formalin-fixed paraffin-embedded tissue samples, while case 2 was diagnosed using fluorescence in situ hybridization analysis. Conclusion: It is highly likely for many cases of SC to be initially diagnosed as acinic cell carcinoma (AciCC) owing to their similar histological findings. The treatment strategy for minor salivary gland-originated SC is the same as that for AciCC, but SC is often highly malignant and involves a high risk of cervical lymph node metastasis. Making an accurate diagnosis in cooperation with pathologists and confirming the presence of the ETV6-NTRK3 fusion gene using genetic analysis is important.

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Section: Casesupporting

confidence: 91%

Section: Case Presentation Casesupporting

confidence: 91%

Diagnosis and Treatment of Secretory Carcinoma of the Oral Cavity: Report of Two Cases and Pooled Analysis of the Recent Literature

Ogawa¹,

Yokoo²,

Yamaguchi³

et al. 2021

Preprint

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“…Esta mucina es un marcador de la superficie apical de la membrana de los epiteliocitos ductales. En los tumores puede estar difusamente extendida por el citoplasma y más que un marcador de células luminales es un indicador del comportamiento agresivo de los tumores malignos de glándulas salivales 11 . MUC-1 asociada al cáncer salival presenta una glicosilación aberrante y una abundante expresión, con pérdida de la localización apical, ocupando toda la superficie de la membrana, el citoplasma de las células tumorales y, a veces, el núcleo celular como demostraron Ma et al 38 en 40 pacientes con carcinoma de células acinares de glándulas salivales.…”

Section: Discussionunclassified

“…La mucina humana MUC-1/EMA asociada a membrana tiene una localización exclusivamente apical en tejidos normales y tumores benignos. Por el contrario, en los tumores malignos se expresa en toda la superficie de la membrana y aún dentro del citoplasma 11 . La inmunorreactividad para MUC1 en células tumorales se categorizó en: 0: no reactiva; 1: menos del 10% de células tumorales +; 2: 10 al 25% +; 3: 25 a 50% +; 4: 50 a 75%+ o más.…”

Section: Materials Y Métodosunclassified

Aciniccell carcinoma of the salivary glands: clinical and histopathological study of 12 cases

Me¹,

A²,

Ferraris³

et al. 2021

RevFacOdont

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Objective:Acinic cell carcinoma (CCA) is the third malignant epithelial tumor of the salivary glands in adults; low-grade tumor of malignancy, composed of neoplastic cells with serous acinar differentiation. The objective of this work was to analyze 12 cases of CCA according to their location, clinical characteristics, histological and immunohistochemical pattern and cell types, following the latest classification of the World Health Organization. Methods: The study included 12 cases of CCA from the files of salivary tumor biopsies of our work team, corresponding to the period 1997-2020. A numerical code was used to identify the samples, preserving the identity of the patients. Histological sections of the paraffin-embedded biopsies were evaluated with H/E, PAS and Toluidine blue and immunostained with the monoclonal antibodies pancytokeratin AE1 / AE3, Ki67, MUC-1 and mammaglobin. Results: The most frequent histologic pattern was the solid type as a single pattern or integrated with other patterns of lesser development, with almost exclusive location in the parotid gland and more frequent in women. Cells like normal acinar serocytes predominated in the solid growth pattern. The most frequent cell type in the microcystic patternwas the nonspecific glandular cell together with a lower proportion of acinar and intercalated duct-like cells. The papillary-cystic pattern was lined by nonspecific glandular cells. No clear cells found. With Ki67 a low cell proliferation was demonstrated in all the cases studied. Cell labeling for MUC-1 was grade 1 positive (less than 10% immunoreactive cells) and negative for mammaglobin.Conclusions: Patient follow-up is a priority because CCA tends to recur and metastasize and its behavior can become aggressive. We must deepen the study of its proliferative capacity as a treatment and prognosis tool, especially with immunohistochemistry and standardized molecular biology methods.

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“…These findings are consistent with the immunostaining findings frequently observed in SC. [ 4 , 13 – 16 ] The MIB-1 index, which indicates tumor cell proliferative activity, was 3% (Fig. 3 A-H).…”

Section: Case Presentationmentioning

confidence: 99%

Diagnosis and treatment of secretory carcinoma arising from the oral minor salivary gland

et al. 2021

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Introduction: Secretory carcinoma (SC) is a malignancy of the salivary glands, which is similar to SC of the breast regarding its association with neurotrophic tyrosine receptor kinase fusion-positive gene. SC is a recently described salivary gland tumor, and there are a few reports describing oral minor salivary gland-derived SC. We reported two cases of SC in the oral cavity and reviewed the literature. Patient concerns: The patients included a 65-year-old Japanese woman who presented with a mass of the upper lip and an 84-year-old Japanese man who presented with a mass on the buccal mucosa. Diagnosis: Diagnosis was based on histomorphological and immunohistochemical findings and identification of a specific translocation of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 gene fusion. Case 1 was finally diagnosed using reverse transcription-polymerase chain reaction with formalin-fixed paraffin-embedded tissue samples, while case 2 was diagnosed using fluorescence in situ hybridization analysis. Interventions and outcomes: In case 1, excisional biopsy was done and there was no recurrence observed in five-year follow-up. In case 2, tumor resection was done and there was no recurrence observed in two-year follow-up. Conclusion: It is highly likely for many cases of SC to be initially diagnosed as acinic cell carcinoma (AciCC) owing to their similar histological findings. The treatment strategy for minor salivary gland-originated SC is similar to that of AciCC; however, SC is often highly malignant and involves a high risk of cervical lymph node metastasis. Thus, establishing an accurate diagnosis together with pathologists and confirming the presence of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 fusion gene using genetic analysis is important.

show abstract

Epithelial membrane antigen and DOG1 expression in minor salivary gland tumours

Cited by 8 publications

References 15 publications

Diagnosis and Treatment of Secretory Carcinoma of the Oral Cavity: Report of Two Cases and Pooled Analysis of the Recent Literature

Diagnosis and Treatment of Secretory Carcinoma of the Oral Cavity: Report of Two Cases and Pooled Analysis of the Recent Literature

Aciniccell carcinoma of the salivary glands: clinical and histopathological study of 12 cases

Diagnosis and treatment of secretory carcinoma arising from the oral minor salivary gland

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