Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing

Mao, Mei-Qi; Jing, Jing; Miao, Yujie; Lv, Zhongfa

doi:10.3389/fmed.2022.863786

Cited by 8 publications

(4 citation statements)

References 91 publications

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“…Importantly, Shh signaling is predominantly important for the DP cell function. Shh can promote HF neogenesis in scarred wounds by generating DP cells [ 46 ] ( Figure 1 ).…”

Section: Molecular Pathways Regulating Stem Cell Properties Of Hairmentioning

confidence: 99%

Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells

et al. 2023

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Stem cells have demonstrated significant potential for tissue engineering and repair, anti-aging, and rejuvenation. Hair follicle stem cells can be found in the dermal papilla at the base of the follicle and the bulge region, and they have garnered increased attention because of their potential to regenerate hair as well as their application for tissue repair. In recent years, these cells have been shown to affect hair restoration and prevent hair loss. These stem cells are endowed with mesenchymal characteristics and exhibit self-renewal and can differentiate into diverse cell types. As research in this field continues, it is probable that insights regarding stem cell maintenance, as well as their self-renewal and differentiation abilities, will benefit the application of these cells. In addition, an in-depth discussion is required regarding the molecular basis of cellular signaling and the influence of nature-derived compounds in stimulating the stemness properties of dermal papilla stem cells. This review summarizes (i) the potential of the mesenchymal cells component of the hair follicle as a target for drug action; (ii) the molecular mechanism of dermal papilla stem cells for maintenance of their stem cell function; and (iii) the positive effects of the natural product compounds in stimulating stemness in dermal papilla stem cells. Together, these insights may help facilitate the development of novel effective hair loss prevention and treatment.

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“…Importantly, Shh signaling is predominantly important for the DP cell function. Shh can promote HF neogenesis in scarred wounds by generating DP cells [ 46 ] ( Figure 1 ).…”

Section: Molecular Pathways Regulating Stem Cell Properties Of Hairmentioning

confidence: 99%

Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells

et al. 2023

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“…EMI is a common biological activity that happens in teeth generation, lung organogenesis, and mammary gland morphogenesis, which is also the prerequisite for functional HF formation, regeneration, and cycling [ 96 ]. EMI includes the exchanging of soluble molecules between cells, altering cellular pathways, and cell–ECM transduction, which is the theoretical basis for the application of tissue engineering for HF regeneration [ 16 ].…”

Section: Cell-only Hair Follicle Regenerationmentioning

confidence: 99%

Cells, growth factors and biomaterials used in tissue engineering for hair follicles regeneration

et al. 2022

Regenerative Therapy

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“…Among these, HGF and VEGF have been found to be the main factors involved in angiogenesis, by inducing the formation of blood vessels within the hair follicles [8]. HGF has also been reported to regulate the hair follicle morphogenesis, including the cell proliferation, differentiation, and apoptosis [9]. Likewise, KGF (or FGF-7) is known to regulate the hair follicle proliferation and differentiation, to stimulate the hair fiber elongation in human scalp hair follicles, as well as to inhibit the hair cycle transition from the anagen to the catagen phase [10].…”

Section: Introductionmentioning

confidence: 99%

Mechanistic synergy of hair growth promotion by the Avicennia marina extract and its active constituent (avicequinone C) in dermal papilla cells isolated from androgenic alopecia patients

et al. 2023

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Androgenic alopecia (AGA) is associated with an increased production of 5α-dihydrotestosterone (DHT) by steroid-5α-reductase (5α-R). Crude extracts from Avicennia marina (AM) and its active constituent, avicequinone C (AC), can inhibit 5α-R. We have, herein, explored the potential use of the AM extract and of AC as anti-AGA agents. To this end, we employed human dermal papilla cells (DPCs) isolated from AGA patients’ hair that express 5α-R type-1 as well as the androgenic receptor (AR) at high levels. Our in vitro experiments revealed that the AM extract (10 μg/mL) and the AC (10 μM) exhibit multiple actions that interfere with the mechanism that causes AGA. Beside acting as 5α-R inhibitors, both preparations were able to inhibit either the DHT-AR complex formation or its translocation from the cytoplasm into the nucleus (the site of DHT’s action). The treatments also increased the gene expression of growth factors in DPCs; these factors play important roles in the angiogenesis associated with hair growth. Moreover, the AM extract suppressed the apoptotic pathway, thereby postponing the initiation of the catagen phase. Taken together, our findings suggest that the AM extract and the AC could serve as natural sources for hair growth promotion and AGA treatment.

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Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing

Cited by 8 publications

References 91 publications

Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells

Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells

Cells, growth factors and biomaterials used in tissue engineering for hair follicles regeneration

Mechanistic synergy of hair growth promotion by the Avicennia marina extract and its active constituent (avicequinone C) in dermal papilla cells isolated from androgenic alopecia patients

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