Epithelial-mesenchymal interactions: a fundamental Developmental Biology mechanism

Ribatti, Doménico; Santoiemma, Marcello

doi:10.1387/ijdb.140143dr

Cited by 45 publications

(28 citation statements)

References 47 publications

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“…In the process of embryonic skin stratification, an essential BMP-FGF signaling axis in the dermis responds to the epidermal Wnts and feeds back to regulate basal progenitors marked by p63 (28). Similar to skin development, the development and homeostatic maintenance of the mucosa, which consists of a superficial epithelium and the underlying lamina propria, also require interactions between the epithelium and the lamina propria (29,30,38,39). During intestinal mucosa development, epithelium-derived growth factor Hh plays a critical role in the formation of the lamina propria mesenchymal cells, which in turn contribute to the supportive microenvironment of the epithelial stem cell niche (38).…”

Section: Discussionmentioning

confidence: 99%

A Wnt/Notch/Pax7 signaling network supports tissue integrity in tongue development

Zhu

Yuan

Wang

et al. 2017

Journal of Biological Chemistry

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The tongue is one of the major structures involved in human food intake and speech. Tongue malformations such as aglossia, microglossia, and ankyloglossia are congenital birth defects, greatly affecting individuals' quality of life. However, the molecular basis of the tissue-tissue interactions that ensure tissue morphogenesis to form a functional tongue remains largely unknown. Here we show that -mediated epithelial deletion of (), the key regulator for intracellular Wnt trafficking, leads to lingual hypoplasia in mice. Disruption of epithelial Wnt production by deletion in epithelial cells led to a failure in lingual epidermal stratification and loss of the lamina propria and the underlying superior longitudinal muscle in developing mouse tongues. These defective phenotypes resulted from a reduction in epithelial basal cells positive for the basal epidermal marker protein p63 and from impaired proliferation and differentiation in connective tissue and paired box 3 (Pax3)- and Pax7-positive muscle progenitor cells. We also found that epithelial Wnt production is required for activation of the Notch signaling pathway, which promotes proliferation of myogenic progenitor cells. Notch signaling in turn negatively regulated Wnt signaling during tongue morphogenesis. We further show that is a direct Notch target gene in the embryonic tongue. In summary, our findings demonstrate a key role for the lingual epithelial signals in supporting the integrity of the lamina propria and muscular tissue during tongue development and that a Wnt/Notch/Pax7 genetic hierarchy is involved in this development.

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Section: Discussionmentioning

confidence: 99%

A Wnt/Notch/Pax7 signaling network supports tissue integrity in tongue development

Zhu

Yuan

Wang

et al. 2017

Journal of Biological Chemistry

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“…The myotome cells develop into the musculature of the limbs, while cells derived from the lateral plate give rise to the skeletal elements of the limb. Limb bud outgrowth depends upon reciprocal interactions between the AER and limb bud mesenchyme, the specifics of which can be found in textbooks of embryology (e.g., Carlson, ; Schoenwolf et al, ) and review articles (e.g., Amprino, ; Hopyan, Sharpe, & Yang, ; Ribatti & Santoiemma, ; Wolpert, ).…”

Section: Embryology Of the Skeletonmentioning

confidence: 99%

Bone development in laboratory mammals used in developmental toxicity studies

DeSesso

2018

Birth Defects Research

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Evaluation of the skeleton in laboratory animals is a standard component of developmental toxicology testing. Standard methods of performing the evaluation have been established, and modification of the evaluation using imaging technologies is under development. The embryology of the rodent, rabbit, and primate skeleton has been characterized in detail and summarized herein. The rich literature on variations and malformations in skeletal development that can occur in the offspring of normal animals and animals exposed to test articles in toxicology studies is reviewed. These perturbations of skeletal development include ossification delays, alterations in number, shape, and size of ossification centers, and alterations in numbers of ribs and vertebrae. Because the skeleton is undergoing developmental changes at the time fetuses are evaluated in most study designs, transient delays in development can produce apparent findings of abnormal skeletal structure. The determination of whether a finding represents a permanent change in embryo development with adverse consequences for the organism is important in study interpretation. Knowledge of embryological processes and schedules can assist in interpretation of skeletal findings. K E Y W O R D Sembryology, developmental toxicity testing, embryofetal toxicology testing, ossification, skeletal development, supernumerary ribs, wavy ribs | DEFINITION OF THE PROBLEMDevelopmental toxicity testing includes assessment of the near-term fetal skeleton in laboratory animals, particularly rats, mice, and rabbits. Alterations associated with treatment usually are categorized as malformations or variations, defined in section 2, below. The distinction between variations and malformations is not always clear, and different laboratories may produce different assessments. The biological importance of variations may also be unclear. We will review the published data on these skeletal findings with emphasis on the biological significance of the skeletal changes that have been the most variably interpreted.We are not the first authors to undertake an assessment of developmental changes in the skeleton. Among the helpful reviews in the literature are those by Kimmel and Wilson (1973), Chernoff and Rogers (2004), Tyl, Chernoff, and Rogers (2007), Daston and Seed (2007), Carney and Kimmel (2007), Beyer et al. (2011), Kimmel, Garry, andDeSesso (2014), and Hofmann, Buesen, Schneider, and van Ravenzwaay (2016). | REGULATORY REQUIREMENTS | TechniquesMost pharmaceutical and many non-pharmaceutical chemicals are evaluated for developmental toxicity in experimental animals prior to marketing approval. The requirements for pharmaceutical chemicals have been harmonized for use in Europe, the US, and Japan (ICH, 2005(ICH, , 2017 wileyonlinelibrary.com/journal/bdr2 1157 examination of preferably all fetuses is part of the developmental toxicity evaluation; however, the method of skeletal examination is not specified. The newer techniques of microcomputerized tomography and magnetic resonance imaging ...

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“…In contrast, AR in the mesenchyme surrounding the WD epithelium is essential for the above-mentioned processes (Murashima et al 2011). Epithelial-mesenchymal interactions are a requisite for several developmental processes (Ribatti & Santoiemma 2014). The above-mentioned results, along with earlier studies, for example, on leucine-rich repeat-containing G protein-coupled receptor 4 (lgr4, Mendive et al 2006) and inhibin beta-A (Inhba, Tomaszewski et al 2007) demonstrate the need for epithelial-mesenchymal interactions in the development of WD derivatives as well.…”

Section: Androgensmentioning

confidence: 99%

Segment-specific regulation of epididymal gene expression

Sipilä¹,

Björkgren²

2016

Reproduction

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The epididymis is necessary for post-testicular sperm maturation. During their epididymal transit, spermatozoa gain ability for progressive movement and fertilization. The epididymis is composed of several segments that have distinct gene expression profiles that enable the establishment of the changing luminal environment required for sperm maturation. The epididymal gene expression is regulated by endocrine, lumicrine, and paracrine factors in a segment-specific manner. Thus, in addition to its importance for male fertility, the epididymis is a valuable model tissue for studying the regulation of gene expression. This review concentrates on recent advances in understanding the androgen, small RNA, and epigenetically mediated regulation of segment-specific gene expression in the epididymis.Reproduction (2016) 152 R91-R99

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Epithelial-mesenchymal interactions: a fundamental Developmental Biology mechanism

Cited by 45 publications

References 47 publications

A Wnt/Notch/Pax7 signaling network supports tissue integrity in tongue development

A Wnt/Notch/Pax7 signaling network supports tissue integrity in tongue development

Bone development in laboratory mammals used in developmental toxicity studies

Segment-specific regulation of epididymal gene expression

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