Epithelial—Mesenchymal Interactions in Intestinal Epithelial Differentiation

Kédinger, Michèle; Simon‐Assmann, Patricia; Bouziges, Françoise; Haffen, K

doi:10.3109/00365528809095915

Cited by 67 publications

(32 citation statements)

References 21 publications

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“…In the avian and mammalian digestive tract, it has been amply shown that epithelial-mesenchymal or connective tissue interactions occur during the embryonic organogenesis and the postembryonic homeostasis (Kedinger et al, 1988;Louvard et al, 1992;Yasugi, 1993;Mizuno, 1994), suggesting the existence of common key signaling pathways for such interactions. Indeed, the Shh/BMP-4 signaling pathway shown to be involved in the amphibian intestinal remodeling has also been proposed to play roles in the embryonic gut organogenesis of terrestrial vertebrates (Roberts, 2000;Zhang et al, 2001; and the postembryonic epithelial cell-renewal of the mammalian intestine (Howe et al, 2001;Madison et al, 2004;Haramis et al, 2004;He et al, 2004He et al, , 2007Batts et al, 2006).…”

Section: Perspectivesmentioning

confidence: 99%

Regulation of adult intestinal epithelial stem cell development by thyroid hormone during Xenopus laevis metamorphosis

Ishizuya‐Oka

Shi

2007

Developmental Dynamics

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During amphibian metamorphosis, most or all of the larval intestinal epithelial cells undergo apoptosis. In contrast, stem cells of yet-unknown origin actively proliferate and, under the influence of the connective tissue, differentiate into the adult epithelium analogous to the mammalian counterpart. Thus, amphibian intestinal remodeling is useful for studying the stem cell niche, the clarification of which is urgently needed for regenerative therapies. This review highlights the molecular aspects of the niche using the Xenopus laevis intestine as a model. Because amphibian metamorphosis is completely controlled by thyroid hormone (TH), the analysis of TH response genes serves as a powerful means for clarifying its molecular mechanisms. Although functional analysis of the genes is still on the way, recent progresses in organ culture and transgenic studies have gradually uncovered important roles of cell-cell and cell-extracellular matrix interactions through stromelysin-3 and sonic hedgehog/bone morphogenetic protein-4 signaling pathway in the epithelial stem cell development. Developmental Dynamics 236:3358 -3368, 2007.

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Section: Perspectivesmentioning

confidence: 99%

Regulation of adult intestinal epithelial stem cell development by thyroid hormone during Xenopus laevis metamorphosis

Ishizuya‐Oka

Shi

2007

Developmental Dynamics

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“…The adult primordia include stem cells that are analogous to those in the mammalian intestine (Ishizuya-Oka et al, 2003), rapidly grow in size by active cell proliferation, and then differentiate into the intestinal absorptive epithelium similar to the mammalian counterpart (Hourdry and Dauca, 1977;Shi and Ishizuya-Oka, 1996). We previously indicated that the connective tissue, which develops during metamorphosis, is necessary for adult epithelial development in the Xenopus laevis intestine (Ishizuya-Oka and Shimozawa, 1992), similar to the requirement of mesenchyme for epithelial development in the embryonic gut of higher vertebrates (Kedinger et al, 1988;Yasugi, 1993). Thus, the amphibian intestinal remodeling serves as a good model system for studying mesenchymal factors that regulate stem cells and/or their descendants to form the intestinal epithelium of terrestrial vertebrates.…”

Section: Introductionmentioning

confidence: 99%

Shh/BMP‐4 signaling pathway is essential for intestinal epithelial development during Xenopus larval‐to‐adult remodeling

Ishizuya‐Oka

Hasebe

Shimizu

et al. 2006

Developmental Dynamics

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“…This fibroblast layer is known to synthesize some components of the extracellular matrix that influence the differentiation ofthe epithelial cells (3)(4)(5). The subepithelial fibroblastic network consists ofmyofibroblasts with contractile capability and is thought to contribute to mucosal repair and reepithelialization by decreasing the villus surface area after an injury (6,7).…”

Section: Introductionmentioning

confidence: 99%

Fibroblasts modulate intestinal secretory responses to inflammatory mediators.

Berschneider¹,

Powell²

1992

J. Clin. Invest.

111

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Cultured colonic epithelial cells and fibroblasts were used to examine the interaction between these cell types during intestinal secretion. Secretory responses of T84 colonic epithelial cells, measured as changes in the short-circuit current in modified Ussing chambers to bradykininl, serotonin, hydrogen peroxide, and histamine, were enhanced in the presence of fibroblasts, either in cocultures or when separate cultures of fibroblasts were acutely juxtaposed with the T84 cultures. This effect was abolished by pretreatment with indomethacin and the fibroblasts were found to release prostaglandin E2 in response to these inflammatory mediators. Fibroblasts may exert a paracrine regulation on the secretory response of intestinal epithelial cells via the generation and release ofcyclooxygenase products in response to inflammatory mediators. These studies suggest a novel function for the intestinal fibroblastic sheath: that ofamplification ofthe inflammatory response through mesenchymal/epithelial interaction. (J. Clin. Invest. 1992.

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Epithelial—Mesenchymal Interactions in Intestinal Epithelial Differentiation

Cited by 67 publications

References 21 publications

Regulation of adult intestinal epithelial stem cell development by thyroid hormone during Xenopus laevis metamorphosis

Regulation of adult intestinal epithelial stem cell development by thyroid hormone during Xenopus laevis metamorphosis

Shh/BMP‐4 signaling pathway is essential for intestinal epithelial development during Xenopus larval‐to‐adult remodeling

Fibroblasts modulate intestinal secretory responses to inflammatory mediators.

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