Epithelial‐mesenchymal transition during invasion of cutaneous squamous cell carcinoma is paralleled by
            <scp>AKT</scp>
            activation

Barrette, Kathleen; Kelst, Sofie Van; Wouters, Jasper; Marasigan, Vivien; Fieuws, Steffen; Agostinis, Patrizia; Oord, Joost van den; Garmyn, Marjan

doi:10.1111/bjd.12967

Cited by 33 publications

(40 citation statements)

References 25 publications

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“…EMT is thought to be remodeling of the cytoskeleton, such as down regulation of epithelial keratins, which leads to alterations in cell-to-cell adhesions and changes in polarity and cell motility[32]. Loss of keratin expression is a hallmark of psoriasis and skin tumors[33, 34], and EMT is believed to support invasiveness of tumors and metastasis formation[35, 36]. In our study, K24 decreased expression of mesenchymal markers such as N-cadherin and slug, whereas it increased epithelial marker E-cadherin.…”

Section: Discussionmentioning

confidence: 99%

Role of keratin 24 in human epidermal keratinocytes

et al. 2017

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Keratin 24 (K24) is a new kind of keratin genes, which encodes a novel keratin protein, K24 that bears high similarity to the type I keratins and displays a unique expression profile. However, the role of K24 is incompletely understood. In our study, we investigated the localization of K24 within the epidermis and possible functions. Keratin 24 was found to be modestly overexpressed in senescent keratinocytes and was mainly restricted to the upper stratum spinosum of epidermis. The protein was required for terminal differentiation upon CaCl2-induced differentiation. In vitro results showed that increased K24 in keratinocytes dramatically changed the differentiation of primary keratinocytes. It also inhibited cell survival by G1/S phase cell cycle arrest and induced senescence, autophagy and apoptosis of keratinocytes. In addition, K24 activated PKCδ signal pathway involving in cellular survival. In summary, K24 may be suggested as a potential differentiation marker and anti-proliferative factor in the epidermis.

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Section: Discussionmentioning

confidence: 99%

Role of keratin 24 in human epidermal keratinocytes

et al. 2017

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“…There are also changes in cellular proteins, such as integrins and a-smooth muscle actin, as well as ECM proteins, such as collagen, laminin, and fibronectin. 149,[213][214][215][216][220][221][222][223] The HNSCC cells that undergo EMT have been shown to be more invasive. * The loss of E-cadherin associated with EMT is an indicator of poor prognosis in HNSCC.…”

Section: 213-219mentioning

confidence: 99%

Mechanisms of Invasion in Head and Neck Cancer

Jimenez¹,

Jayakar²,

Ow³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-The highly invasive properties demonstrated by head and neck squamous cell carcinoma (HNSCC) are often associated with locoregional recurrence and lymph node metastasis in patients and is a key factor leading to an expected 5-year survival rate of approximately 50% for patients with advanced disease. It is important to understand the features and mediators of HNSCC invasion so that new treatment approaches can be developed.Objectives.-To provide an overview of the characteristics, mediators, and mechanisms of HNSCC invasion.Data Sources.-A literature review of peer-reviewed articles in PubMed on HNSCC invasion.Conclusions.-Histologic features of HNSCC tumors can help predict prognosis and influence clinical treatment decisions. Cell surface receptors, signaling pathways, proteases, invadopodia function, epithelial-mesenchymal transition, microRNAs, and tumor microenvironment are all involved in the regulation of the invasive behavior of HNSCC cells. Identifying effective HNSCC invasion inhibitors has the potential to improve outcomes for patients by reducing the rate of spread and increasing responsiveness to chemoradiation.

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“…According to our results, the invasion pattern of SCC showed significant differences between the oral cavity and lower lip. Based on former investigations, 3 15,16 There are reports of EMT in cutaneous SCCs 17 and it seems that the invasive behavior of lower lip SCC might be similar to SCCs of the skin in this regard. In contrast to lip SCC, the CCI pattern with the ECad+/NCadÀ/Pod+ profile was more prevalent in OSCC.…”

Section: Discussionmentioning

confidence: 97%