Epithelial–mesenchymal transition in gingival tissues from chronic periodontitis patients: A case–control study

Wadie, Karim Wasfi; Bashir, Maha Hassan; Abbass, Marwa M. S.

doi:10.17219/dmp/133514

Cited by 10 publications

(8 citation statements)

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“…Literature suggests a direct link between chronic periodontitis and levels of oxidative stress-related biomarkers in GCF [ 52 ]. Wadie et al concluded that the severity of periodontitis is related to the expression of cytokines such as TGF-β and vimentin [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Estimation of gingival crevicular fluid oxidative stress markers in school-aged children and teenagers with insufficient sleep

et al. 2022

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Background Sleep is crucial for survival. Sleep deprivation causes ROS accumulation and, consequently, oxidative stress. The goal of the study was to evaluate gingival crevicular fluid (GCF) levels of the oxidative stress status hydrogen peroxide (H2O2), superoxide glutathione (GSH), and cellular oxidative damage marker malondialdehyde (MDA) in school-aged children and teenagers with insufficient sleep. Methods This study investigated sleep duration in 80 participants from two different developmental stages: school-aged children (6–13 years) and teenagers (14–17 years). GCF samples were obtained from all individuals, and samples were investigated to detect H2O2, GSH, and MDA levels using the micro method. Results Results reveal that GCF MDA and H2O2 in school-age children and teenagers with insufficient sleep were significantly higher than in children with sufficient sleep. GCF GSH with insufficient sleep was insignificantly lower than in children with sufficient sleep. There was no significant difference between school-age and teenage populations. Conclusion Sleep deprivation causes increased levels of oxidative stress in gingival crevicular fluid, and adequate sleep is essential for maintaining redox balance.

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Section: Discussionmentioning

confidence: 99%

Estimation of gingival crevicular fluid oxidative stress markers in school-aged children and teenagers with insufficient sleep

et al. 2022

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“…Data demonstrated down-regulation of cell adhesion proteins such as E-cadherin and connexins-26 and − 43 in the lining epithelium of periodontal pockets [198] . Notably, a direct correlation between the severity of periodontitis and the expression of the EMT biomarkers was demonstrated [199] . Analysis of tissue samples from patients with periodontitis has also demonstrated down-regulation of E-cadherin which is a major indicator of EMT [200] .…”

Section: In Vitro Animal Model and Clinical Evidence Suppor...mentioning

confidence: 98%

Pathogenesis of periodontitis – A potential role for epithelial-mesenchymal transition

Saliem

Bede

Cooper

et al. 2022

Japanese Dental Science Review

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“…VIM expression is also regulated by TGF and proinflammatory cytokines. VIM expression increased significantly as periodontitis developed severe [38].…”

Section: Vimmentioning

confidence: 99%

Identifying Common Genes and Pathways Associated with Periodontitis and Aging by Bioinformatics Analysis

Xie

Wang

et al. 2022

Disease Markers

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Background. This work used bioinformatic analysis to identify the relationship between periodontitis (PD) and aging, which could lead to new treatments for periodontal disease in the elderly. Method. Four microarray datasets were obtained from the Gene Expression Omnibus (GEO) database and analyzed in R language to identify differentially expressed genes (DEGs). The common DEGs of PD and aging were evaluated as key genes in this investigation by a Venn diagram. These common DEGs were analyzed through additional experiments and analysis, such as pathway analysis and enrichment analysis, and a network of protein-protein interactions (PPIs) was constructed. Cytoscape was used to visualize hub genes and critical modules based on the PPI network. Interaction of TF-genes and miRNAs with hub genes is identified. Result. 84 common DEGs were found between PD and aging. Cytohubba was performed on the PPI network obtained from STRING tool, and the top 10 genes (MMP2, PDGFRB, CTGF, CD34, CXCL12, VIM, IL2RG, ACTA2, COL4A2, and TAGLN) were selected as hub genes. VIM may be a potential biomarker in the analysis of linked hub gene regulatory networks, and hsa-mir-21 and hsa-mir-125b are predicted to be associated in PD and aging. Conclusion. This study investigated the key genes and pathways interactions between PD and aging, which may help reveal the correlation between PD and aging. The current research results are obtained by prediction, and follow-up biological experiments are required for further verification.

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Epithelial–mesenchymal transition in gingival tissues from chronic periodontitis patients: A case–control study

Cited by 10 publications

References 0 publications

Estimation of gingival crevicular fluid oxidative stress markers in school-aged children and teenagers with insufficient sleep

Estimation of gingival crevicular fluid oxidative stress markers in school-aged children and teenagers with insufficient sleep

Pathogenesis of periodontitis – A potential role for epithelial-mesenchymal transition

Identifying Common Genes and Pathways Associated with Periodontitis and Aging by Bioinformatics Analysis

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