Epithelial-mesenchymal transition-related circular RNAs in lung carcinoma

Jiang, Meina; Fang, Shuai; Zhao, Xiaodong; Zhou, Chengwei; Gong, Zhaohui

doi:10.20892/j.issn.2095-3941.2020.0238

Cited by 9 publications

(5 citation statements)

References 69 publications

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“…The abnormal activation of cell cycle‐related proteins accelerates tumor progression, 23 and the occurrence of epithelial‐mesenchymal transition (EMT) and extracellular matrix (ECM) remodeling caused by MMPs are characteristics positively correlated with tumor invasion and metastasis 24–26 . CircABCA13 overexpressing obviously upregulated cyclin D1, cyclin D3, N‐cadherin, MMP‐2, and MMP‐9 and downregulated E‐cadherin (Figures 2J and S3E), while the opposite effects were observed in circABCA13 knockdown cells.…”

Section: Resultsmentioning

confidence: 99%

CircABCA13 acts as a miR‐4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1

et al. 2023

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Circular RNAs (circRNAs) play a pivotal role in the tumorigenesis and progression of various cancers. However, the role and mechanisms of circABCA13 in esophageal squamous cell carcinoma (ESCC) are largely unknown. Here, we reported that circABCA13, a novel circular RNA generated by back‐splicing of the intron of the ABCA13 gene, is highly expressed in ESCC tumor tissues and cell lines. Upregulation of circABCA13 correlated with TNM stage and a poor prognosis in ESCC patients. While knockdown of circABCA13 in ESCC cells significantly reduced cell proliferation, migration, invasion, and anchorage‐independent growth, overexpression of circABCA13 facilitated tumor growth both in vitro and in vivo. In addition, circABCA13 directly binds to miR‐4429 and sequesters miR‐4429 from its endogenous target, SRXN1 mRNA, which subsequently upregulates SRXN1 and promotes ESCC progression. Consistently, overexpression of miR‐4429 or knockdown of SRXN1 abolished malignant behavior promotion of ESCC results from circABCA13 overexpression in vitro and in vivo. Collectively, our study uncovered the oncogenic role of circABCA13 and its mechanism in ESCC, suggesting that circABCA13 could be a potential therapeutic target and a predictive biomarker for ESCC patients.

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Section: Resultsmentioning

confidence: 99%

CircABCA13 acts as a miR‐4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1

et al. 2023

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“…During this process, which is considered a trigger of cancer metastasis, epithelial cells lose their polarity and differentiated state, and acquire a mesenchymal-like phenotype. Some circRNAs have been found to act as competing endogenous RNAs (ceRNAs) for miRs involved in EMT signaling pathways, thus leading to tumor progression 57 , although the underlying mechanisms are uncertain. In this review, we dissect the roles of signaling pathways in malignant carcinomas, focusing on molecular mechanisms and prospects for future intervention ( Table 1 ).…”

Section: Multiple Signaling Pathways Of Circrnas In Cancersmentioning

confidence: 99%

Circular RNAs: implications of signaling pathways and bioinformatics in human cancer

Peng

Fan

et al. 2023

Cancer Biol Med

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Circular RNAs (circRNAs) form a class of endogenous single-stranded RNA transcripts that are widely expressed in eukaryotic cells. These RNAs mediate post-transcriptional control of gene expression and have multiple functions in biological processes, such as transcriptional regulation and splicing. They serve predominantly as microRNA sponges, RNA-binding proteins, and templates for translation. More importantly, circRNAs are involved in cancer progression, and may serve as promising biomarkers for tumor diagnosis and therapy. Although traditional experimental methods are usually time-consuming and laborious, substantial progress has been made in exploring potential circRNA-disease associations by using computational models, summarized signaling pathway data, and other databases. Here, we review the biological characteristics and functions of circRNAs, including their roles in cancer. Specifically, we focus on the signaling pathways associated with carcinogenesis, and the status of circRNA-associated bioinformatics databases. Finally, we explore the potential roles of circRNAs as prognostic biomarkers in cancer.

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“…In addition to Hippo/yap, nuclear factor-kappa B (NF-κB), janus kinases/signal transducer and activator of transcription proteins (JAK/STAT), mitogen-activated protein kinases (MAPK), and phosphatidylinositol 3-kinase (PI3K)/Akt/ mechanistic target of rapamycin (mTOR), investigations on each of these pathways have been the subject of new developments in the last 3 years and are reviewed below. Meanwhile, the role of potential additional factors that drive EMT in cancer (Figure 2) was also highlighted, namely transcriptional factors (TFs) (Vishnoi et al, 2020), translation initiation mechanisms (Bera and Lewis, 2020), miRNAs (Pan et al, 2021) and circular RNAs (circRNAs) (Jiang M. et al, 2021), hypoxia (Peng P. H. et al, 2021), inflammation (Chattopadhyay et al, 2021, and stromal components like tumor-associated macrophages (TAMs) (Han et al, 2021) and cancer-associated fibroblasts (CAFs) (Asif et al, 2021). Other emerging or developing research fields were represented by cancer-associated adipocytes (Liu et al, 2020), endothelial cells and their transformation via endothelial-tomesenchymal transition (EndMT) (Yoshimatsu and Watabe, 2022), and vascular mimicry (Sun et al, 2017).…”

Section: Overview Of Emt Driving Parameters In Cancer An Updatementioning

confidence: 99%

Curcuminoids as Modulators of EMT in Invasive Cancers: A Review of Molecular Targets With the Contribution of Malignant Mesothelioma Studies

et al. 2022

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Curcuminoids, which include natural acyclic diarylheptanoids and the synthetic analogs of curcumin, have considerable potential for fighting against all the characteristics of invasive cancers. The epithelial-to-mesenchymal transition (EMT) is a fundamental process for embryonic morphogenesis, however, the last decade has confirmed it orchestrates many features of cancer invasiveness, such as tumor cell stemness, metabolic rewiring, and drug resistance. A wealth of studies has revealed EMT in cancer is in fact driven by an increasing number of parameters, and thus understanding its complexity has now become a cornerstone for defining future therapeutic strategies dealing with cancer progression and metastasis. A specificity of curcuminoids is their ability to target multiple molecular targets, modulate several signaling pathways, modify tumor microenvironments and enhance the host’s immune response. Although the effects of curcumin on these various parameters have been the subject of many reviews, the role of curcuminoids against EMT in the context of cancer have never been reviewed so far. This review first provides an updated overview of all EMT drivers, including signaling pathways, transcription factors, non-coding RNAs (ncRNAs) and tumor microenvironment components, with a special focus on the most recent findings. Secondly, for each of these drivers the effects of curcumin/curcuminoids on specific molecular targets are analyzed. Finally, we address some common findings observed between data reported in the literature and the results of investigations we conducted on experimental malignant mesothelioma, a model of invasive cancer representing a useful tool for studies on EMT and cancer.

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Epithelial-mesenchymal transition-related circular RNAs in lung carcinoma

Cited by 9 publications

References 69 publications

CircABCA13 acts as a miR‐4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1

CircABCA13 acts as a miR‐4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1

Circular RNAs: implications of signaling pathways and bioinformatics in human cancer

Curcuminoids as Modulators of EMT in Invasive Cancers: A Review of Molecular Targets With the Contribution of Malignant Mesothelioma Studies

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