Epithelial Migration On The Tympanic Membrane: An Experimental Study

Boedts, D; Kuijpers, W.

doi:10.3109/00016487809121447

Cited by 20 publications

(19 citation statements)

References 10 publications

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“…The concave shape and the adhesive forces provided by the mineral oil are similar to those conferred by the convex shape of the cornea and the surface tension characteristics of the lacrimal fluid, which provide positional stability for ophthalmic contact lenses. Periodically, the patient atomizes a small amount of mineral oil into the ear canal to replenish the oil lost by slow skin migration (Reijnen and Kuijpers, 1971; Boedts and Kuijpers, 1978). …”

Section: Methodsmentioning

confidence: 99%

“…Among the first reported examples of this, in which electromagnetic fields were used to generate forces on a magnet attached to the TM, thus resulting in the sensation of hearing, were those by Wilska (1959), Rutschmann (1959), Goode (1970), and Plester et al (1978). However, none of these earlier attempts have been deemed practical, since the attachment of magnets to the eardrum was not well tolerated due to the migration of the eardrum epithelium (Reijnen and Kuijpers, 1971; Boedts and Kuijpers, 1978). The attachment problem was not solved until the development of the EarLens platform.…”

Section: Introductionmentioning

confidence: 99%

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The EarLens system: New sound transduction methods

Perkins¹,

Fay²,

Rucker³

et al. 2010

Hearing Research

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The hypothesis is tested that an open-canal hearing device, with a microphone in the ear canal, can be designed to provide amplification over a wide bandwidth and without acoustic feedback. In the design under consideration, a transducer consisting of a thin silicone platform with an embedded magnet is placed directly on the tympanic membrane. Sound picked up by a microphone in the ear canal, including sound-localization cues thought to be useful for speech perception in noisy environments, is processed and amplified, and then used to drive a coil near the tympanic-membrane transducer. The perception of sound results from the vibration of the transducer in response the electromagnetic field produced by the coil. Sixteen subjects (ranging from normal-hearing to moderately hearing-impaired) wore this transducer for up to a ten-month period, and were monitored for any adverse reactions. Three key functional characteristics were measured: 1) the maximum equivalent pressure output (MEPO) of the transducer; 2) the feedback gain margin (GM), which describes the maximum allowable gain before feedback occurs; and 3) the tympanic-membrane damping effect (D TM ), which describes the change in hearing level due to placement of the transducer on the eardrum. Results indicate that the tympanic-membrane transducer remains in place and is well tolerated. The system can produce sufficient output to reach threshold for those with as much as 60 dBHL of hearing impairment for up to 8 kHz in 86% of the study population, and up to 11.2 kHz in 50% of the population. The feedback gain margin is on average 30 dB except at the ear canal resonance frequencies of 3 and 9 kHz, where the average was reduced to 12 dB and 23 dB respectively. The average value of D TM is close to 0 dB everywhere except in the 2-4 kHz range, where it peaks at 8 dB. A new alternative system that uses photonic energy to transmit both the signal and power to a photodiode and micro-actuator on an EarLens platform is also described.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The EarLens system: New sound transduction methods

Perkins¹,

Fay²,

Rucker³

et al. 2010

Hearing Research

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show abstract

“…Direct observation of dots of India ink placed on the tympanic membrane of hamsters did not allow any pathways of migration to be observed by Boedts and Kuijpers (1978) because the dots moved so rapidly that the tympanic membrane was cleared in 1-2 days. In the guinea pig, O'Donoghue (1983) was able to observe that dye markings moved mainly in a superior direction.…”

Section: Discussionmentioning

confidence: 99%

“…The study of Litton in the guinea pig (1968) did not include the PF, and that of Boedts and Kuijpers (1978) in the mouse did not reveal any particular localization of tritiated thymidine in the PF.…”

Section: Discussionmentioning

confidence: 99%

Auditory epithelial migration. III. development of the stratified squamous epithelium of the tympanic membrane and external canal in the mouse

Michaels¹,

Soucek

1991

Am. J. Anat.

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The development of the stratified squamous epithelium of the tympanic membrane and external auditory canal was studied in serial sections of 124 mouse ears aged from 11 gestational days to 100 days. A fold developed from the edge of the fundus of the primary canal. It possessed two regions: firstly the meatal plate, which produced the pars tensa-covering epithelium (zone 2) and most of the deep ear canal epithelium (zone 3), and secondly the fundal extension plate, which grew from that part of the fundus not forming the meatal plate. The fundal extension plate gave rise to the pars flaccida-covering epithelium (zone 1) and also to the adjacent deep canal epithelium (zone 3). A difference from human development was that zone 3 in the mouse, in both the meatal plate- and the fundal extension plate-derived areas, formed adnexal structures. In the early development of the meatal plate, zone 3, at its tip, was swollen and actively mitotic and extended always for a short distance on to the zone 2 side. Zone 2, first perceived two days after zone 3, became progressively attenuated, and by the fourth day after its formation was a single thin layer. It is suggested that the proximal part of zone 3, situated in the mature ear around the periphery of the tympanic membrane, is a generation center for unidirectional outward flux of epithelium which terminates in the mouse at the first adnexal structure. It may cause the whole of zone 2 to move in the same direction by negative contact inhibition.

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“…The pathogenesis of acquired cholesteatoma is, however, a complex and debatable topic. Several theories have been put forward and four fundamentally different origins were postulated: invagination, basal cell hyperplasia, migration and the metaplastic theories (1)(2)(3). The invagination theory of the genesis of cholesteatoma is generally regarded as one of the primary mechanisms of retraction pocket cholesteatoma, such as attic and sinus cholesteatoma.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Study of Cell Proliferation using BrdU Labelling on Tympanic Membrane, External Auditory Canal and Induced Cholesteatoma in Mongolian Gerbils

Park

Chun²,

Park³

et al. 1999

Acta Oto-Laryngologica

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The Mongolian gerbil is a well-known animal model for induction of aural cholesteatomas. This animal model is useful for studying changes in the keratinizing epithelium. It is not known whether keratin accumulation can increase the proliferative activity of the keratinizing epithelium in tympanic membrane and meatal skin. In this study, we investigated the proliferative activity of the epidermis in induced aural cholesteatoma at various stages and in different areas of the tympanic membrane and meatal skin in normal gerbils. Anti-5-bromo-2- deoxyuridine (BrdU) was injected intraperitoneally to detect the proliferative activity of keratinizing epithelium. Immunohistochemistry with monoclonal BrdU antibody in the normal gerbil showed intense immunolabelled keratinocytes at the handle of malleus, and the superior parts of pars tensa and pars flaccida. Also, mitotic activity in the deep meatal skin was more active than in the lateral meatal skin. The induced aural cholesteatoma showed more active proliferation centre of the epithelial cell than eardrum and external ear canal of the normal gerbil. These observations suggest that the accumulation of the keratin debris might induce changes of the cellular proliferation in the external auditory meatus.

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Epithelial Migration On The Tympanic Membrane: An Experimental Study

Cited by 20 publications

References 10 publications

The EarLens system: New sound transduction methods

The EarLens system: New sound transduction methods

Auditory epithelial migration. III. development of the stratified squamous epithelium of the tympanic membrane and external canal in the mouse

Immunohistochemical Study of Cell Proliferation using BrdU Labelling on Tympanic Membrane, External Auditory Canal and Induced Cholesteatoma in Mongolian Gerbils

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