Epithelial Migration Over Tympanic Membrane and External Canal

Litton, Ward B.

doi:10.1001/archotol.77.3.34

Cited by 26 publications

(27 citation statements)

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“…Literature search revealed that there have been no direct, objective comparative studies done with regard to epithelial migration in the TM and EAC in normal ears or ears with pathologic abnormalities. The epithelial migration in the EAC was observed subjectively and compared without any direct measurement (8,9). In certain pathologic conditions of the TM and EAC, migration in the EAC was reported to be both normal and abnormal (9Y11).…”

Section: Discussionmentioning

confidence: 99%

Study of Epithelial Migration in the Tympanic Membrane and Bony External Auditory Canal Wall in Patients With Irradiated Nasopharyngeal Carcinoma

Kalimuthu¹,

Prepageran²,

Tang³

et al. 2015

Otology &Amp; Neurotology

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Section: Discussionmentioning

confidence: 99%

Study of Epithelial Migration in the Tympanic Membrane and Bony External Auditory Canal Wall in Patients With Irradiated Nasopharyngeal Carcinoma

Kalimuthu¹,

Prepageran²,

Tang³

et al. 2015

Otology &Amp; Neurotology

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“…[4][5][6][7] We have therefore reported on patterns of the auditory epithelial migration (AEM) in the rat visualized by means of a dye marking technique. 8 This species shows almost the same pathway patterns as found in the human.…”

Section: Introductionmentioning

confidence: 99%

Auditory Epithelial Migration III: An Immunohistologic Study Using Anti-Brdu Antibody on Tympanic Membrane in Mouse

Kakoi¹,

Anniko²

1997

Ann Otol Rhinol Laryngol

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A localization pattern of epidermal cells on the tympanic membrane (TM) and their migratory patterns were studied in mice, by means of immunohistologic technique using an anti-bromodeoxyuridine (BrdU) antibody. The BrdU was instilled intraperitoneally and the animals were painlessly sacrificed between 1 hour and 10 days after the injection. An immunostaining technique using anti-BrdU antibodies was applied on whole mount TM tissues. One hour after injection, BrdU-labeled cells were found in the handle of the malleus (HM) region and in the annular region of the pars tensa of the TM. Some labeled cells were observed in the intermediate region of the upper half of the superior quadrant, but no labeled cells were found in the remaining part of the intermediate region. Labeled cells were also evident in the pars flaccida without any particular pattern of distribution. As time elapsed after the injection, the labeled cells first appearing in the HM region had migrated laterally and inferiorly from the HM toward the annulus, while those in the annular region had considerably decreased in number. Results of the present study are the following: 1) the proliferation center of epidermal cells in the pars tensa is located in two different areas, i.e., the HM region and annular region, 2) newly generated cells in the HM region migrated from the HM region toward the annular region, whereas those in the annular region migrate from the the annular region to the external auditory canal, and 3) no specific generation center is located in the pars flaccida. On the basis of these results, we discuss the relationship between the site of the proliferation center of epidermal cells and their migratory patterns.

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“…A multitude of authors have specifically studied epithelial migration. Litton placed ink dots on his subjects' tympanic membranes, ultimately concluding that epithelial migration occurs in a centrifugal pattern from the umbo [13]. In a separate original article, Alberti presented findings that echoed Litton's and suggested that these migratory patterns are self-cleansing by nature [14].…”

Section: Discussionmentioning

confidence: 97%

“…Methods: A retrospective chart review of all patients with medial tube migration seen in a Pediatric Otolaryngology practice at a tertiary care university hospital between 1995 and 2005. Results: Six pediatric patients (ages [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] were found to have seven tympanostomy tubes within the middle ear space at various intervals following tube placement. One patient had a migrated tympanostomy tube deep to a large myringotomy incision.…”

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confidence: 99%