1990
DOI: 10.1152/ajplung.1990.258.6.l254
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Epithelial modulation of airway smooth muscle

Abstract: The responsiveness of airway smooth muscle is influenced by the functional integrity of the respiratory epithelium. The nature of this regulatory action by the epithelium remains largely unresolved. Several explanations may account for the epithelium-dependent responses induced by numerous stimuli. This review will present and discuss the evidence suggesting that the epithelium generates an inhibitory signal or signals that function to modulate the responsiveness of the underlying smooth muscle. In addition, t… Show more

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Cited by 39 publications
(34 citation statements)
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“…The epithelium is one potential source for such a substance [18][19][20][21], as are the subepithelial tissues [22]. Heterogeneous responses to ACh have been reported to occur in canine [20] and porcine [21] bronchial rings following epithelial removal, but this does not appear to be the case in perfused segments up to 3 mm in internal diameter [23].…”
Section: Discussionmentioning
confidence: 99%
“…The epithelium is one potential source for such a substance [18][19][20][21], as are the subepithelial tissues [22]. Heterogeneous responses to ACh have been reported to occur in canine [20] and porcine [21] bronchial rings following epithelial removal, but this does not appear to be the case in perfused segments up to 3 mm in internal diameter [23].…”
Section: Discussionmentioning
confidence: 99%
“…The respiratory epithelium not only acts as a physical barrier, it may release a factor(s) to inhibit the responses of the underlying smooth muscle to a variety of bronchoconstrictors including acetylcholine (Flavahan et al, 1985;Barnes et al, 1985;Vanhoutte, 1988;Morrison et al, 1990). In the present study, the difference in contractions to acetylcholine between tissues with and without epithelium was not affected by nitro-L-arginine, oxyhaemoglobin, or methylene blue.…”
Section: Isometric Tensionmentioning
confidence: 41%
“…A similar role in Th2 biasing of T cell responses has been shown in BALB/c mice through inhibition of IFN-␥ (11). The diverse biological effects of PGE 2 are attributable to the presence of four receptors (EP [1][2][3][4] ), of which two are positively coupled to adenylate cyclase (EP 2 and EP 4 ) and two (EP 1 and EP 3 ) act by stimulating phosphoinositide-specific phospholipase C and inhibit adenylate cyclase (reviewed in Ref. 12).…”
mentioning
confidence: 60%
“…It is produced by epithelial cells and is potently bronchoprotective against contractile agonists in vitro (reviewed in Ref. 1). When exogenous PGE 2 is administered to allergic human subjects before allergen provocation testing, it is inhibitory of both early and late allergic airway narrowing (2) and also airway hyperresponsiveness (AHR) 3 to inhaled contractile agonists such as methacholine (2).…”
mentioning
confidence: 99%