Epithelial muscarinic M1 receptors contribute to carbachol-induced ion secretion in mouse colon

Cholinergic Modulation of Epithelial Integrity in the Proximal Colon of Pigs

“…Both receptor types participated in the formation of a tight epithelium during epidermal regeneration and wound healing [Grando, 1997[Grando, , 2006. Several studies have demonstrated mAChR and nAChR expression in epithelial cells of the digestive tract [O'Malley et al, 1995;Nguyen et al, 2000;Yang and Frucht, 2000;Richardson et al, 2003;Haberberger et al, 2006;Jonsson et al, 2007].…”

Stimulation of Na+‐K+‐pump currents by epithelial nicotinic receptors in rat colon

“…In contrast, muscarinic receptors are observed pre‐ and postsynaptically in neurons, and they mediate the action of this transmitter in organs or tissues innervated by the autonomous nervous system. For example, in the gut, M 1 receptors are found on epithelial cells (Haberberger et al, , Wessler and Kirkpatrick, ) and on enteric neurons (North et al, ), M 2 receptors on smooth muscle cells (Bhattacharya et al . ) and M 3 receptors on epithelial and smooth muscle cells (Wessler and Kirkpatrick, ).…”

Immunohistochemical localisation of cholinergic muscarinic receptor subtype 1 (M1r) in the guinea pig and human enteric nervous system

“…M1rs have been suggested to be on epithelial cells in mouse colon (Haberberger et al, 2006). In human bladder, M1r mRNA is present in mucosa (Mansfield et al, 2005).…”

“…Muscarinic www.elsevier.com/locate/jchemneu Journal of Chemical Neuroanatomy 33 (2007) 193-201 receptors modulating release of neurotransmitters other than ACh has also been documented (Iverson et al, 1997;Hamrouni et al, 2006). M1rs have also been suggested to have a role in mucosal secretion and are present on epithelial cells in the mouse colon (Haberberger et al, 2006).…”