Epithelial-Myoepithelial Carcinoma in Minor Salivary Gland of the Hard Palate

Teppo, Heikki; Paronen, I

doi:10.1097/scs.0b013e318189723a

Cited by 14 publications

(12 citation statements)

References 9 publications

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“…In the minor glands of the oral mucosa, EMC represents approximately 5% of all salivary gland tumours. To our knowledge, only 10 cases of EMC in the palate have been reported in the English literature; here we have presented an additional case. Table summarises the cases previously reported in the literature.…”

Section: Discussionsupporting

confidence: 51%

Epithelial‐myoepithelial carcinoma arising in the palate: a rare case report and review of the literature

Kawamata¹,

Yamane²,

Nakazato

2014

Oral Surgery

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This report describes our recent experience with a case of epithelialmyoepithelial carcinoma of the left palate and reviews previously reported cases of this rare malignancy. A 68-year-old woman presented with painless nodular swelling of the left hard palate. Histopathological and immunohistochemical analyses confirmed a diagnosis of epithelial-myoepithelial carcinoma. We performed a partial maxillectomy through a lateral rhinotomy incision under general anaesthesia. During the surgery, the entire tumour mass was removed with clear surgical margins. The patient continued to undergo clinical follow-up and radiological assessments for a period of 2.5 years with no evidence of recurrent or metastatic disease. Epithelialmyoepithelial carcinoma is a rare malignancy that requires immunohistochemical validation of diagnosis and may be successfully treated with surgery alone.

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Section: Discussionsupporting

confidence: 51%

Epithelial‐myoepithelial carcinoma arising in the palate: a rare case report and review of the literature

Kawamata¹,

Yamane²,

Nakazato

2014

Oral Surgery

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“…EMC is a biphasic tumor (4,6,7,11,13). Histologically, it is characterized by double layered duct-like structures (1,2,6).…”

Section: Discussionmentioning

confidence: 99%

Epithelial-Myoepithelial Carcinoma with High Grade Transformation of Nasal Cavity

et al. 2016

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High grade transformation in epithelial-myoepithelial carcino¬ma is a recently defined entity with only a few cases reported in the literature. We present a 59 years old female patient with a polypoid lesion in nasal cavity, together with clinical com¬plaints as recurrent epistaxis and stuffiness. Histological and immunohistochemical examination of the surgically excised le¬sion revealed a diagnosis of epithelialmyoepithelial carcino¬ma with high grade transformation. Epithelial-myoepithelial carcinoma originates from salivary glands, mainly parotid gland. Other affected sites are submandibular gland and minor sali¬vary glands. Epithelialmyoepithelial carcinoma is characterized by double layered duct-like structures. Greater cytologi¬cal atypia, higher mitotic rate, presence of necrosis and loss of the biphasic ductlike structures are features of high grade transformation. Local recurrence and cervical lymph node me¬tastases are seen with low incidence in classical epithelial-myoepithelial carcinoma, whereas epithelial-myoepithelial carcinoma with high grade transformation has high tendency for lymph node and distant metastases.

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“…1,2 Carcinoma expleomorphic adenoma contains elements of benign PA as well as frankly malignant epithelial compo nents amounting to 2 to 5% of the PA. 9,10 Carcinoma arising in CXPA is most commonly adenocarcinoma, undifferentia ted carcinoma and rarely squamous cell carcinoma. 11,12 Misdiagnosis are bound to occur as the carcinoma represent various subtypes in the residual PA on histopathology while the imaging modality plays no role. 13,14 Here, we report a rare case of malignant myoepithelial carcinoma expleomor phic adenoma of the hard palate and its management.…”

Section: 5005/jp-journals-10001-1185mentioning

confidence: 99%

Malignant Myoepithelial Carcinoma Expleomorphic Adenoma of the Hard Palate: An Aggressive Tumor with Diagnostic Dilemma

Naik¹,

Halkud²,

Siddappa³

et al. 2014

International Journal of Head and Neck Surgery

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Background/Objectives: Myoepithelial carcinomas are uncommon neoplasms that account for about 10% of all myoepitheliomas. The invasiveness varies from a locally aggressive to highly metastatic tumor which may arise de novo or in a pleomorphic adenoma. Myoepitheliomas arise from myoepithelial cells lacking ductal differentiation which exhibit both epithelial and smooth muscle cell elements.Case report: we report a case of palatal swelling excised 4 years back, as pleomorphic adenoma, which later recurred as malignant myoepithelial carcinoma expleomorphic adenoma of the palate. CECT of the paranasal air sinuses did not show any bony invasion of the hard palate. So he was given radical radiotherapy with concurrent chemotherapy but after 3 years developed recurrence and metastasis to the skin and the lungs. The patient was referred to oral chemotherapy on a palliative basis. Conclusion:Malignant myoepithelial carcinoma expleomorphic adenoma of the hard palate is a highly aggressive rare tumor of the hard palate. Radical management with surgery and adjuvant chemoradiotherapy improves survival in these patients. Followup with metastatic workup should be accurate as the tumor is highly aggressive with poor prognosis.

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Epithelial-Myoepithelial Carcinoma in Minor Salivary Gland of the Hard Palate

Cited by 14 publications

References 9 publications

Epithelial‐myoepithelial carcinoma arising in the palate: a rare case report and review of the literature

Epithelial‐myoepithelial carcinoma arising in the palate: a rare case report and review of the literature

Epithelial-Myoepithelial Carcinoma with High Grade Transformation of Nasal Cavity

Malignant Myoepithelial Carcinoma Expleomorphic Adenoma of the Hard Palate: An Aggressive Tumor with Diagnostic Dilemma

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