2023
DOI: 10.1101/2023.12.01.569395
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Epithelial organoid supports resident memory CD8 T cell differentiation

Max R. Ulibarri,
Ying Lin,
Julian R. Ramprashad
et al.

Abstract: Resident Memory T cells (TRM) play a vital role in regional immune defense in barrier organs. Although laboratory rodents have been extensively used to study fundamental TRM biology, poor isolation efficiency, sampling bias and low cell survival rates have limited our ability to conduct TRM-focused high-throughput assays. Here, we engineered a murine vaginal epithelial organoid (VEO)-CD8 T cell co-culture system that supports CD8 TRM differentiationin vitro. The three-dimensional VEOs established from murine a… Show more

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