Epithelial Salivary Gland Tumors in Children and Adolescents

Seifert, G.; Okabe, Haruo; Caselitz, J.

doi:10.1159/000275859

Cited by 79 publications

(17 citation statements)

References 10 publications

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“…It has been estimated that about 1% to 5% of all salivary gland tumors develop in children and adolescents [1,8], and MEC is the most common malignancy [5,9,39,40]. In the current LSUSD series, 3.5% of the epithelial minor salivary gland neoplasms occurred in patients 19 years of age or younger; this is in close agreement with the series reported by Waldron et al .…”

Section: Discussionsupporting

confidence: 89%

Minor salivary gland mucoepidermoid carcinoma in children and adolescents: a case series and review of the literature

2012

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IntroductionBecause well-documented cases of mucoepidermoid carcinomas that are of minor salivary gland origin and occur in children and adolescents have rarely been reported, little information regarding their clinical features and biologic behavior is available. This case report represents a retrospective clinical analysis of five minor salivary gland mucoepidermoid carcinomas accessioned from a 35-year period at the Louisiana State University School of Dentistry and combines the data with 15 well-documented cases from the English language literature.Case presentationThe five mucoepidermoid carcinomas in patients from birth to 19 years of age accounted for 1.3% of the accessioned minor salivary gland neoplasms. There were an additional 15 well-documented cases in the literature. Combining the data for the 20 mucoepidermoid carcinomas resulted in a mean age of 13.5 years and a 2.3:1 female-to-male ratio. Collectively, the hard palate, soft palate, and hard palate/soft palate junction accounted for 85% of the cases. Thirty-five percent of the cases presented as a fluctuant submucosal swelling with surface color alterations. The average duration was five months, and bone involvement occurred in seven cases. A histologic grade of low to intermediate predominated (95%). Surgical removal was the treatment in all cases. Thirteen cases had adequate follow-up of three years or more, and recurrence was documented in only one case. There were no cases of death or metastasis in this series.ConclusionsIn children and adolescents, mucoepidermoid carcinomas have a female predilection and occur most commonly on the hard or soft palate or both. A fluctuant submucosal lump with a bluish color is a helpful diagnostic clue. The histologic grades of most mucoepidermoid carcinomas in the first and second decades of life are low and, to a lesser degree, intermediate. Complete surgical excision is the treatment of choice and results in a recurrence rate of less than 10%.

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Section: Discussionsupporting

confidence: 89%

Minor salivary gland mucoepidermoid carcinoma in children and adolescents: a case series and review of the literature

2012

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“…[17][18][19] Guzzo et al reported that the most common sites are the parotid, submandibular, and sublingual glands. 20 In the present study the male to female ratio was 1:2, similar to previous data from Castro et al 5 and Seifert et al 21 and confirms in the pediatric group the well-known predominance of the salivary gland tumors for the female sex. This was also in line with other studies 22,23 excepting for one study by Shafkat et al 17 which showed that had males have more tendency to develop salivary gland tumors.…”

Section: Discussionsupporting

confidence: 93%

Salivary Gland Neoplasms in Indian Paediatric Population Visiting a Dental Institution

Biradar¹,

Kulkarni²,

Kulkarni³

et al. 2019

IHRJ

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INTRODUCTION: With a probability of 50% malignancy, salivary gland tumors are not too commonly noticed in children and adolescents. Most of these have idiopathic etiology but a few pre-disposing factors have been reported in literature. We hereby report eighteen cases of paediatric salivary gland tumors in a study conducted from September 2013 to August 2018 at department of Oral and maxillofacial surgery at Tatyasaheb Kore Dental college and Research Centre, Kohlapur, Maharashtra, India..AIM & OBJECTIVES: This study aimed to inspect the distribution, clinical and histopathological features of salivary gland tumours in children and adolescents.MATERIAL AND METHODS: A total of 18 cases of salivary gland tumors encountered in paediatric age group were studied and explored for age, gender, site proneness and for histopathological nature.RESULTS: Female gender had a predominance over males. Parotid tumors were more common (77.78%) as compared to tumors of submandibular glands. Six cases were diagnosed with benign tumors (pleomorphic adenoma) and rest had malignant tumors (mucoepidermoid in nature). Majority of the cases did not report undergoing any prior treatment.CONCLUSION Present study revealed that salivary gland tumors in paediatric age group are quite rare with female gender being more prone. With majority of cases being mucoepidermoid in nature, parotid gland is most commonly affected.

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“…A PA is composed of a wide spectrum of epithelial and mesenchymal tissue derived from cells with ductal and myoepithelial features and it is by far the most common salivary gland neoplasm in children [1,32]. Although it is commonly stated that neoplasms of minor salivary glands rarely occur prior to the second decade [33], we found that, when combining the well-documented literature cases with our LSUSD cases, 28.6% of PAs arising from minor salivary glands in children occurred during the first decade of life.…”

Section: Discussionmentioning

confidence: 99%

A clinical analysis of nine new pediatric and adolescent cases of benign minor salivary gland neoplasms and a review of the literature

Ritwik

Brannon

2012

J Med Case Reports

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IntroductionMinor salivary gland neoplasms of epithelial origin are rare in children and adolescents and most are not well documented, except for a few small series and case reports. This study represents a retrospective clinical analysis of nine cases of benign epithelial salivary gland neoplasms accessioned over a 35-year period at the Louisiana State University School of Dentistry and combines the data with well-documented cases from the English-language literature.MethodsA retrospective clinical analysis of nine cases of benign epithelial salivary gland neoplasms was performed over a 35-year period at the Louisiana State University School of Dentistry and combined with data of well-documented cases from the English-language literature.ResultsThe nine benign salivary gland neoplasms in patients aged 19 months to 18 years accounted for 2.3% of the Louisiana State University School of Dentistry accessioned salivary gland tumors. These nine cases comprised eight pleomorphic adenomas and one cystadenoma. There were 40 cases in the literature, of which 34 were pleomorphic adenomas. Combining the data for the 42 pleomorphic adenomas resulted in a mean age of 12 years with a 2.8:1 female predilection. The hard palate and/or soft palate were the most common site (69.1%). The average duration and size was 2.1 years and 2.4cm, respectively. Bone involvement occurred in seven cases. Wide local excision was the treatment most often employed. Cases followed for two years or more had a recurrence rate of 13.0%. The remaining seven neoplasms in the combined data comprised myoepithelioma, cystadenoma and sialadenoma papilliferum.ConclusionsA relatively long duration (2 years) of a submucosal mass in a minor salivary gland-bearing area with or without bone involvement occurring in a child or adolescent should raise the question of a possible salivary gland neoplasm. A pleomorphic adenoma is the most common benign salivary gland neoplasm in the first and second decade of life. Complete surgical excision affords the best chance of preventing recurrence for pleomorphic adenomas. The recurrence rate of pleomorphic adenomas with two or more years follow-up is 13.0%. Other types of minor salivary gland neoplasms are exceedingly rare and therefore data is sparse, precluding any valid conclusions.

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Epithelial Salivary Gland Tumors in Children and Adolescents

Cited by 79 publications

References 10 publications

Minor salivary gland mucoepidermoid carcinoma in children and adolescents: a case series and review of the literature

Minor salivary gland mucoepidermoid carcinoma in children and adolescents: a case series and review of the literature

Salivary Gland Neoplasms in Indian Paediatric Population Visiting a Dental Institution

A clinical analysis of nine new pediatric and adolescent cases of benign minor salivary gland neoplasms and a review of the literature

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