Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia

Huang, Shu-Ching; Liang, Jia Y.; Vu, Long V.; Yu, Faye; Ou, Alexander; Ou, Jennie Park; Zhang, Henry S.; Burnett, Kimberly; Benz, Edward J.

doi:10.1074/jbc.ra119.009650

Cited by 5 publications

(2 citation statements)

References 79 publications

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“…These adaptor proteins are comparable to the integrin-linked intracellular mechanotransducers, as they connect Cads to the actin cytoskeleton. The same mechanisms and principles as discussed above also apply for AJs and qualify the actin cytoskeleton not only as the common final pathway of AJs and FAs signaling, but also as a crosstalk platform that integrates mechanical cues transmitted through various MT pathways [97,98]. ERK1/2, YAP, and its cellular homologue transcriptional co-activator with PDZ motif (TAZ), vinculin and FAK, are both addressed by AJs and FAs, underscoring the complex mutuality of cell-to-cell and cell-to-matrix adhesion (Figure 1B) [17,[99][100][101].…”

Section: Figurementioning

confidence: 84%

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

et al. 2021

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Among oral tissues, the periodontium is permanently subjected to mechanical forces resulting from chewing, mastication, or orthodontic appliances. Molecularly, these movements induce a series of subsequent signaling processes, which are embedded in the biological concept of cellular mechanotransduction (MT). Cell and tissue structures, ranging from the extracellular matrix (ECM) to the plasma membrane, the cytosol and the nucleus, are involved in MT. Dysregulation of the diverse, fine-tuned interaction of molecular players responsible for transmitting biophysical environmental information into the cell’s inner milieu can lead to and promote serious diseases, such as periodontitis or oral squamous cell carcinoma (OSCC). Therefore, periodontal integrity and regeneration is highly dependent on the proper integration and regulation of mechanobiological signals in the context of cell behavior. Recent experimental findings have increased the understanding of classical cellular mechanosensing mechanisms by both integrating exogenic factors such as bacterial gingipain proteases and newly discovered cell-inherent functions of mechanoresponsive co-transcriptional regulators such as the Yes-associated protein 1 (YAP1) or the nuclear cytoskeleton. Regarding periodontal MT research, this review offers insights into the current trends and open aspects. Concerning oral regenerative medicine or weakening of periodontal tissue diseases, perspectives on future applications of mechanobiological principles are discussed.

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Section: Figurementioning

confidence: 84%

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

et al. 2021

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“…Additionally, it remains unclear how actin-spectrin components are connected to the 4.1G-MPP6-CADM4 complex in the PNS, considering that actin abundantly forms filaments in SLIs [24]. Notably, the SAB domain is spliced in the retina [22], and another actin-binding peptide sequence was found in 4.1R near the common SAB domain in epithelial cells [25]. Thus, the relationship between 4.1G and the actin filaments in SLIs has not been clarified.…”

Section: Protein 41g In Pnsmentioning

confidence: 99%

Recent Progress on Genetically Modified Animal Models for Membrane Skeletal Proteins: The 4.1 and MPP Families

Terada,

Saitoh,

Saito

et al. 2023

Genes

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The protein 4.1 and membrane palmitoylated protein (MPP) families were originally found as components in the erythrocyte membrane skeletal protein complex, which helps maintain the stability of erythrocyte membranes by linking intramembranous proteins and meshwork structures composed of actin and spectrin under the membranes. Recently, it has been recognized that cells and tissues ubiquitously use this membrane skeletal system. Various intramembranous proteins, including adhesion molecules, ion channels, and receptors, have been shown to interact with the 4.1 and MPP families, regulating cellular and tissue dynamics by binding to intracellular signal transduction proteins. In this review, we focus on our previous studies regarding genetically modified animal models, especially on 4.1G, MPP6, and MPP2, to describe their functional roles in the peripheral nervous system, the central nervous system, the testis, and bone formation. As the membrane skeletal proteins are located at sites that receive signals from outside the cell and transduce signals inside the cell, it is necessary to elucidate their molecular interrelationships, which may broaden the understanding of cell and tissue functions.

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Cell junction proteins: Crossing the glomerular filtration barrier in diabetic nephropathy

Eftekhari

Vahed

Kavetskyy

et al. 2020

International Journal of Biological Macromolecules

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Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia

Cited by 5 publications

References 79 publications

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

Recent Progress on Genetically Modified Animal Models for Membrane Skeletal Proteins: The 4.1 and MPP Families

Cell junction proteins: Crossing the glomerular filtration barrier in diabetic nephropathy

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