Epithelial STAT6 O-GlcNAcylation Drives Anti-Helminth Immunity via a Concerted Alarmin Response

Zhao, Mingli; Ren, Kai; Xiong, Xin; Yue, Xin; Kim, Angela; Maynard, Jason C.; Zou, Yujie; Battist, Alexander P; Koneripalli, Navya; Huang, Zan; Zhang, Zengdi; Yu, Jin; Wang, Haiguang; Salgado, Oscar Camilo; Hogquist, Kristin A.; Revelo, Xavier S.; Burlingame, Alma L.; Gao, Xiang; Lin, Zhaoyu; Moltke, Jakob von; Ruan, Hai‐Bin

doi:10.2139/ssrn.3917158

Cited by 2 publications

(1 citation statement)

References 68 publications

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“…Type 2 cytokines, IL-4 or IL-13, triggered by worm infection, drastically up-regulated the expression of GSDMC in the gut, thereby enhancing the release of antiparasitic factors from enterocytes by GSDMC-mediated pyroptosis and facilitating the clearance of worms (81). Moreover, it was reported that epithelial O-linked N-Acetylglucosamine protein modification was initiated upon helminth infection, boosting GSDMC-mediated membrane pore formation and the unconventional secretion of IL-33, which contributed greatly to anti-helminth immunity and induced intestinal inflammation (23).…”

Section: Gasdermins-mediated Lytic Cell Death In Enteropathogenic Mic...mentioning

confidence: 99%

Intestinal Gasdermins for regulation of inflammation and tumorigenesis

et al. 2022

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Gasdermins (GSDMs) protein family express in intestinal epithelial cells or lamina propria immune cells, and play a nonnegligible function during gut homeostasis. With the gradually in-depth investigation of GSDMs protein family, the proteases that cleave GSDMA-E have been identified. Intestinal GSDMs-induced pyroptosis is demonstrated to play a crucial role in the removal of self-danger molecules and clearance of pathogenic organism infection by mediating inflammatory reaction and collapsing the protective niche for pathogens. Simultaneously, excessive pyroptosis leading to the release of cellular contents including inflammatory mediators into the extracellular environment, enhancing the mucosal immune response. GSDMs-driver pyroptosis also participates in a novel inflammatory cell death, PANoptosis, which makes a significant sense to the initiation and progression of gut diseases. Moreover, GSDMs are expressed in healthy intestinal tissue without obvious pyroptosis and inflammation, indicating the potential intrinsic physiological functions of GSDMs that independent of pyroptotic cell death during maintenance of intestinal homeostasis. This review provides an overview of the latest advances in the physiological and pathological properties of GSDMs, including its mediated pyroptosis, related PANoptosis, and inherent functions independent of pyroptosis, with a focus on their roles involved in intestinal inflammation and tumorigenesis.

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Section: Gasdermins-mediated Lytic Cell Death In Enteropathogenic Mic...mentioning

confidence: 99%

Intestinal Gasdermins for regulation of inflammation and tumorigenesis

et al. 2022

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How Pyroptosis Contributes to Inflammation and Fibroblast-Macrophage Cross-Talk in Rheumatoid Arthritis

Demarco

Danielli

Fischer

et al. 2022

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About thirty years ago, a new form of pro-inflammatory lytic cell death was observed and termed pyroptosis. Only in 2015, gasdermins were defined as molecules that create pores at the plasma membrane and drive pyroptosis. Today, we know that gasdermin-mediated death is an important antimicrobial defence mechanism in bacteria, yeast and mammals as it destroys the intracellular niche for pathogen replication. However, excessive and uncontrolled cell death also contributes to immunopathology in several chronic inflammatory diseases, including arthritis. In this review, we discuss recent findings where pyroptosis contributes to tissue damage and inflammation with a main focus on injury-induced and autoimmune arthritis. We also review novel functions and regulatory mechanisms of the pyroptotic executors gasdermins. Finally, we discuss possible models of how pyroptosis may contribute to the cross-talk between fibroblast and macrophages, and also how this cross-talk may regulate inflammation by modulating inflammasome activation and pyroptosis induction.

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Epithelial STAT6 O-GlcNAcylation Drives Anti-Helminth Immunity via a Concerted Alarmin Response

Cited by 2 publications

References 68 publications

Intestinal Gasdermins for regulation of inflammation and tumorigenesis

Intestinal Gasdermins for regulation of inflammation and tumorigenesis

How Pyroptosis Contributes to Inflammation and Fibroblast-Macrophage Cross-Talk in Rheumatoid Arthritis

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