Epithelial to mesenchymal transition (EMT) in metaplastic breast cancer and phyllodes breast tumors

Akrida, Ioanna; Mulita, Francesk; Plachouri, Kerasia-Maria; Benetatos, Nikolaos; Maroulis, Ioannis; Papadaki, Helen

doi:10.1007/s12032-023-02259-4

Cited by 6 publications

(2 citation statements)

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“…EMT can promote the motility of cancer cells, enabling cancer cells to gain the ability to detach from their primary site and subsequently migrate to distant tissues, and p‐EMT results in collective cancer cell migration. 9 , 10 While MET is crucial for the colonization in the distant tissues, eventually leading to metastasis. 11 Simultaneously, during EMT, the epithelial cells that transform into mesenchymal cells become resistant to chemotherapy, targeted therapies as well as immunotherapy, contributing to the treatment failure of cancer.…”

Section: Introductionmentioning

confidence: 99%

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Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

Wang,

Xue,

Pang

et al. 2024

MedComm

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Currently, cancer is still a leading cause of human death globally. Tumor deterioration comprises multiple events including metastasis, therapeutic resistance and immune evasion, all of which are tightly related to the phenotypic plasticity especially epithelial–mesenchymal plasticity (EMP). Tumor cells with EMP are manifest in three states as epithelial–mesenchymal transition (EMT), partial EMT, and mesenchymal–epithelial transition, which orchestrate the phenotypic switch and heterogeneity of tumor cells via transcriptional regulation and a series of signaling pathways, including transforming growth factor‐β, Wnt/β‐catenin, and Notch. However, due to the complicated nature of EMP, the diverse process of EMP is still not fully understood. In this review, we systematically conclude the biological background, regulating mechanisms of EMP as well as the role of EMP in therapy response. We also summarize a range of small molecule inhibitors, immune‐related therapeutic approaches, and combination therapies that have been developed to target EMP for the outstanding role of EMP‐driven tumor deterioration. Additionally, we explore the potential technique for EMP‐based tumor mechanistic investigation and therapeutic research, which may burst vigorous prospects. Overall, we elucidate the multifaceted aspects of EMP in tumor progression and suggest a promising direction of cancer treatment based on targeting EMP.

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Section: Introductionmentioning

confidence: 99%

“… 12 , 13 Besides, EMP is found to be implicated in the tumor heterogeneity and pathogenesis of some cancers. 10 , 14 Therefore, understanding the mechanisms, regulation and functions of EMP is of great significance for the cancer treatment.…”

Section: Introductionmentioning

confidence: 99%