Epithelial tumors of the lacrimal gland in the Chinese: a clinicopathologic study of 298 patients

Zeng, Jie; Shi, Jitong; Li, Bin; Sun, Xing‐Guo; An, Yu-zhi; Li, Liao-qing; Gao, Fei; Xu, Jianing; Jonas, Jost B.

doi:10.1007/s00417-010-1349-2

Cited by 37 publications

(40 citation statements)

References 10 publications

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“…Carcinoma ex pleomorphic adenoma, adenocarcinoma and mucoepidermoid carcinoma all have a mean age at presentation of approximately 50–52 years (Font & Gamel 1978; Ni et al. 1992; Zeng et al. 2010).…”

Section: Demographicsmentioning

confidence: 99%

Epithelial tumours of the lacrimal gland: a clinical, histopathological, surgical and oncological survey

Holstein

Coupland

Briscoe

et al. 2012

Acta Ophthalmologica

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. Epithelial tumours of the lacrimal gland represent a large spectrum of lesions with similarities in clinical signs and symptoms but with different biological behaviour and prognosis. They are rare, but with aggressive malignant potential. Tumours of the lacrimal gland may present with swelling of the lacrimal gland, displacement of the eyeball, reduced eye motility and diplopia. Pain and symptoms of short duration before the first ophthalmic consultation are characteristic of malignant tumours. The histological diagnosis determines the subsequent treatment regimen and provides important clues regarding the prognosis. The purpose of this paper is to describe the various primary epithelial tumours of the lacrimal gland. In the first part of the review, the frequency, demographics, clinical presentation and diagnostic features are described. In the second part, primarily tumour‐specific histological characteristics are given. Finally, treatment modalities including surgical procedures and medical oncology as well as prognosis are discussed.

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Section: Demographicsmentioning

confidence: 99%

Epithelial tumours of the lacrimal gland: a clinical, histopathological, surgical and oncological survey

Holstein

Coupland

Briscoe

et al. 2012

Acta Ophthalmologica

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“…Primary epithelial neoplasms represent 23-70 % of histologically examined lacrimal gland lesions [1]. Although up to 70 % of lacrimal gland epithelial neoplasms are pleomorphic adenomas [1], and the majority of the remainder is represented by adenoid cystic carcinomas and carcinomas ex-pleomorphic adenoma, rare cases of a wide variety of other histologic types analogous to their salivary gland counterparts, have also been described, mostly as individual case reports.…”

Section: Introductionmentioning

confidence: 99%

“…Although up to 70 % of lacrimal gland epithelial neoplasms are pleomorphic adenomas [1], and the majority of the remainder is represented by adenoid cystic carcinomas and carcinomas ex-pleomorphic adenoma, rare cases of a wide variety of other histologic types analogous to their salivary gland counterparts, have also been described, mostly as individual case reports. Such rare tumors of the lacrimal glands include basal cell adenocarcinoma, ductal carcinoma, acinic cell carcinoma, mucoepidermoid carcinoma, oncocytoma and oncocytic carcinoma, polymorphous low-grade adenocarcinoma, myoepithelioma and myoepithelial carcinoma [2].…”

Section: Introductionmentioning

confidence: 99%

“…Such rare tumors of the lacrimal glands include basal cell adenocarcinoma, ductal carcinoma, acinic cell carcinoma, mucoepidermoid carcinoma, oncocytoma and oncocytic carcinoma, polymorphous low-grade adenocarcinoma, myoepithelioma and myoepithelial carcinoma [2]. The data from 19 series [1,3] reported from 1954 to 2010, comprising 1,366 primary epithelial neoplasms of the lacrimal gland, show that adenoid cystic carcinomas represent about 20 % (range 6-75 %) of all epithelial tumors and about 65 % (range 29-93 %) of all malignant epithelial tumors of the lacrimal gland. It is likely, however, that this is an overestimation of their frequency, since many of these series are from large tertiary cancer centers and from consultation files and show an overrepresentation of malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

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Lacrimal Gland Adenoid Cystic Carcinoma with High-Grade Transformation to Myoepithelial Carcinoma: Report of a Case and Review of Literature

Argyris

Pambuccian

Cayci

et al. 2012

Head and Neck Pathol

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Adenoid cystic carcinoma (AdCC) is the most frequent malignant neoplasm of the lacrimal glands. Like its salivary gland counterpart, lacrimal AdCC can rarely undergo high-grade transformation (''dedifferentiation''). We herein report the clinical, radiographic and microscopic findings of a lacrimal gland AdCC with high grade transformation, occurring in a 39-year-old female patient. In contrast to salivary gland AdCC with high-grade transformation, which usually shows a high grade component with ''ductal'' differentiation, in the case presented, the ''dedifferentiated'' component showed morphologic and immunohistochemical features of myoepithelial differentiation.

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“…Local lymph node metastasis is rare; however, long distance metastasis is very common (2). In addition, the five-year survival rate is relatively high; however, the survival rate between 10 and 20 years is considerably reduced (3,4). ACC originating from the lacrimal gland had a higher tendency to invade the cranial cavity, as compared with tumors from the salivary gland, and the corresponding incidence rate is between 4 and 22% (5).…”

Section: Introductionmentioning

confidence: 99%

Expression of survivin in adenoid cystic carcinoma of the lacrimal gland and the effect of intervention with arsenic trioxide in vitro

Pan

Xing

Wang

2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the role of survivin in adenoid cystic carcinoma of the lacrimal gland (LGACC) and the effect of arsenic trioxide (As 2 O 3 ) intervention in vitro. In total, 13 patients with LGACC were recruited from Renmin Hospital of Wuhan University between 2007 and 2012. The patients were divided into different groups, namely tumor-node-metastasis (TNM)1-2 and TNM3-4, according to the TNM classification. A total of eight samples were included in the TNM1-2 group, while five samples were included in the TNM3-4 group. In addition, six patients that suffered from other diseases (no tumor), but underwent eye surgery, were selected as the controls. The mRNA and protein expression levels of survivin were analyzed. In addition, primary adenoid cystic carcinoma (ACC) cells were cultured and the expression of survivin was silenced using short interfering RNA (siRNA), after which the cell proliferation was determined. Furthermore, the primary cultured ACC cells were treated with different doses of As 2 O 3 to observe the effect on the apoptosis rate. The mRNA and protein expression levels of survivin in the LGACC groups were higher when compared with the controls (P<0.01). In addition, the expression levels were higher in the TNM3-4 group when compared with the TNM1-2 group (P<0.01). After silencing survivin expression using siRNA, the rate of ACC cell proliferation was shown to decrease at days 2, 3, 4 and 5 following culture, particularly in the TNM3-4 group at days 2 and 3 (P<0.05), day 4 (P<0.01 vs. TNM1-2 + siRNA); and days 3 and 5 (P<0.05), and day 2 (P<0.01 vs. TNM3-4 + siRNA). The mRNA expression levels of survivin in the TNM1-2 and TNM3-4 groups were significantly decreased following treatment with the various doses of As 2 O 3 (2, 4 and 6 µΜ) for 48 h, and the apoptosis rate of the ACC cells was markedly increased (TNM1-2 and 3-4: As 2 O 3 6 µM vs. As 2 O 3 2 µM, As 2 O 3 6 µM vs. As 2 O 3 4 Μm, P<0.01; TNF3-4, As 2 O 3 4 µM VS. As 2 O 3 2 µM, P<0.01; TNM1-2, As 2 O 3 4 µM vs. As 2 O 3 2 µM, P<0.05). Therefore, survivin was demonstrated to be highly expressed in ACC cells of the lacrimal gland, and inhibition of survivin gene expression was found to suppress the proliferation of the ACC cells. Furthermore, As 2 O 3 treatment was demonstrated to inhibit the mRNA expression of survivin in the ACC cells, while significantly increasing the apoptosis rate.

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Epithelial tumors of the lacrimal gland in the Chinese: a clinicopathologic study of 298 patients

Cited by 37 publications

References 10 publications

Epithelial tumours of the lacrimal gland: a clinical, histopathological, surgical and oncological survey

Epithelial tumours of the lacrimal gland: a clinical, histopathological, surgical and oncological survey

Lacrimal Gland Adenoid Cystic Carcinoma with High-Grade Transformation to Myoepithelial Carcinoma: Report of a Case and Review of Literature

Expression of survivin in adenoid cystic carcinoma of the lacrimal gland and the effect of intervention with arsenic trioxide in vitro

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