Epithelioid angiomyolipoma of the liver: CT and MRI features

Ji, Jiansong; Chen, Lu; Wang, Zufei; Xu, Min; Shen, Jingjing

doi:10.1007/s00261-012-9911-5

Cited by 46 publications

(52 citation statements)

References 13 publications

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“…Familiarity with the features of hepatic AMLs on clinical imaging could increase the rate of detection and reduce the chance of misdiagnosis. Extensive CT and MRI studies have been performed (Butte et al 2011;Ji et al 2013;Yang et al 2013b;Yu et al 2013) that have documented that CT and MRI, especially with contrast enhancement, are useful tools in the differential diagnosis of hepatic AML before pathologic examination. Although the combination of US, CT and MRI and, occasionally, angiography increases accuracy in diagnosing hepatic AML, the correct pre-operative diagnostic rate of imaging studies has been reported to be less than 50% (Yang et al 2007).…”

Section: Introductionmentioning

confidence: 98%

Hepatic Angiomyolipomas: Ultrasonic Characteristics of 25 Patients from a Single Center

Wang

Chen

et al. 2015

Ultrasound in Medicine & Biology

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Section: Introductionmentioning

confidence: 98%

Hepatic Angiomyolipomas: Ultrasonic Characteristics of 25 Patients from a Single Center

Wang

Chen

et al. 2015

Ultrasound in Medicine & Biology

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“…The preoperative diagnosis of these cases on imaging is very difficult, with a diagnostic accuracy ranging from 0 to 23%. Moreover, the imaging features of this tumour are associated with the histological components; in particular, most tumours were completely devoid of adipose tissue, and hence, fat attenuation was rarely observed on computed tomography and magnetic resonance images . In contrast, nearly all tumours were markedly enhanced in the arterial phase, indicating the presence of a hypervascular tumour .…”

Section: Discussionmentioning

confidence: 94%

Clinico‐pathological correlation of hepatic angiomyolipoma: a series of 23 resection cases

Jung

Hwang

Hong

et al. 2017

ANZ Journal of Surgery

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Background: Angiomyolipomas are rare neoplasms of mesenchymal origin and are derived from perivascular epithelioid cells. They usually develop in the kidney and rarely in the liver. Due to their rarity, most hepatic angiomyolipomas have been misinterpreted as hepatocellular carcinoma (HCC) or other hypervascular liver tumours on imaging studies. We aimed to assess the clinico-pathological correlation of hepatic angiomyolipoma. Methods: We identified 23 patients with hepatic angiomyolipoma through an institutional database search. Results: Of 5680 cases of primary liver tumours, 23 (0.4%) had angiomyolipomas (mean age, 43.6 AE 12.4 years; 16 female patients). Hepatitis B virus infection was noted in four patients, whereas a liver mass was incidentally detected on routine health screening in 13 patients. The preoperative diagnoses, before liver biopsy, included HCC in 14, angiomyolipoma in six, focal nodular hyperplasia in two and hepatic adenoma in one patient. Eventually, the preoperative diagnoses were changed to HCC in 12 and hepatic angiomyolipoma in 11 patients. The tumour size was 5.3 AE 4.6 cm, and 22 patients had a single tumour. All tumours exhibited positive findings for human melanoma black-45 and smooth muscle actin staining. During a follow-up period of 52.2 AE 23.7 months, none of the patients exhibited tumour recurrence or mortality. Conclusions: Hepatic angiomyolipoma is a rare form of primary liver tumour and is often misdiagnosed as other hypervascular tumours. Although angiomyolipoma is benign in nature, it also has malignant potential; hence, resection is indicated if the tumour grows or malignancy cannot be excluded. Surgical resection is a definitive curative treatment of hepatic angiomyolipoma.

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“…The radiologic findings were also non-specific, so that misdiagnosis was common before the pathologic diagnosis. Nearly all tumors were well enhanced in arterial phase because of the high vascularity, and some of them showed decreased enhancement at portal and delayed phase [14]. These findings can mimic the typical radiologic findings of hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Epithelioid angiomyolipoma of the liver: a case report

Lee

Kim

2017

Clin Mol Hepatol

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Epithelioid angiomyolipoma (EAML) of liver is a rare neoplasm. Hepatic EAML is often misdiagnosed as other neoplasms such as hepatocellular carcinoma due to non-specific clinical and radiologic features. The morphologic features under microscope and immunohistochemistry staining profile are important in the diagnosis EAML. Here, we report a case of 52-year-old man who found 1.2 cm mass in liver by routine checkup. On the impression of hepatocellular carcinoma, lateral sectionectomy of the liver was done. Microscopically, the tumor is composed of predominant epithelioid cells with vascular component and foamy cells. These cells were positive for HMB45, MelanA, and smooth muscle actin and negative for epithelial membrane antigen. The final diagnosis was hepatic EAML.

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Epithelioid angiomyolipoma of the liver: CT and MRI features

Cited by 46 publications

References 13 publications

Hepatic Angiomyolipomas: Ultrasonic Characteristics of 25 Patients from a Single Center

Hepatic Angiomyolipomas: Ultrasonic Characteristics of 25 Patients from a Single Center

Clinico‐pathological correlation of hepatic angiomyolipoma: a series of 23 resection cases

Epithelioid angiomyolipoma of the liver: a case report

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