Epithelioid angiosarcoma arising from a frontoparietal arteriovenous malformation

Schüürmann, Monica; Voth, Harald; Ziemer, Mirjana; Simon, Jan C.; Grunewald, Sonja

doi:10.1111/ddg.13727

Cited by 6 publications

(7 citation statements)

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“…Cutaneous AS may arise spontaneously, as a consequence of radiation (radiation-associated angiosarcoma, RAA) or in association with chronic lymphedema (Stewart-Treves syndrome) [3]. There are also reports of angiosarcomas arising from AV fistulas in kidney transplant patients, particularly in patients receiving immunosuppression [4]. The skin is the most common site of primary AS, with 62.1 % of cAS presenting initially in the head and neck area [5].…”

Section: Discussionmentioning

confidence: 99%

A female patient with a receding hairline

Platzer

Steimle-Grauer

Biedermann

et al. 2020

J Deutsche Derma Gesell

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Section: Discussionmentioning

confidence: 99%

A female patient with a receding hairline

Platzer

Steimle-Grauer

Biedermann

et al. 2020

J Deutsche Derma Gesell

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“…Although most ASs arise spontaneously, AS can arise from pre-existing benign vascular lesions, particularly in cases with a history of radiation therapy, which is a well-known risk factor of AS. One report described a case of AS arising from AVM, in which AS arose from a frontoparietal AVM which had been identified many years prior (2). This patient had no history of radiation therapy but had received prednisolone and budesonide for collagenous colitis.…”

Section: Discussionmentioning

confidence: 99%

“…The ISSVA classification categorizes vascular anomalies as vascular tumours that present as neoplastic growths and vascular malformations that have abnormal anastomoses and structures in vessels with poor proliferative ability. Arteriovenous malformation (AVM) is classified as a vascular malformation, and malignant transformation of AVM to AS is extremely rare, with only one case report to date demonstrating AS arising from AVM (2). The present case is the second to describe the possibility of malignant transformation of AVM to AS.…”

Section: Introductionmentioning

confidence: 99%

Possible malignant transformation of arteriovenous malformation to angiosarcoma: case report and literature review

Tanaka

Seike

Tomita

et al. 2019

Journal of Surgical Case Reports

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Angiosarcoma is a rare malignant tumour, which accounts for 1–2% of all malignant soft-tissue tumours. Most cases of angiosarcoma arise spontaneously, and malignant transformation of vascular malformation to angiosarcoma is extremely rare. We describe the case of a 70-year-old woman with a massive arteriovenous malformation in her shoulder, which gradually enlarged, despite repeated surgeries and radiation therapy over 53 years. She also presented with rapidly growing haemorrhagic masses in her oral cavity. Excision biopsy was performed, and the pathohistological diagnosis was angiosarcoma. Positron emission tomography–computed tomography revealed high fluorodeoxyglucose accumulation in the oral cavity and right shoulder, the latter of which was consistent with the location of the arteriovenous malformation. The masses in the oral cavity were diagnosed as metastatic angiosarcoma from the right shoulder, where the massive arteriovenous malformation was suspected to have malignantly transformed. This report describes a possible case of malignant transformation of arteriovenous malformation to angiosarcoma.

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“…Acroangiodermatitis Mali (AM), also known as pseudo-Kaposi sarcoma or acral capillary angiomatosis, is the more common form and represents a reactive angiodysplasia of cutaneous vessels [3]. Cases caused by chronic venous insufficiency, acquired arteriovenous anomalies, paralyzed extremities or amputation stumps have been described [4][5][6][7][8]. The etiology of AM remains elusive, though it has been argued that chronic hypoxia can induce neovascularization and fibroblast proliferation [9].…”

Section: Dear Editorsmentioning

confidence: 99%

Diagnostic workup of acroangiodermatitis of Mali (pseudo‐Kaposi sarcoma) demasking metastasized epithelioid angiosarcoma

Trennheuser

Fink

Haenssle

et al. 2020

J Deutsche Derma Gesell

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A 63-year old man was referred to our outpatient department with an eight-week history of slowly growing, painful skin lesions on his right foot. He also reported a weight loss of 10 kg, occasional fever and excessive spontaneous sweating. He had been experiencing these symptoms for one year. His medical history included arterial hypertension, hyperlipidemia and an operation of an aneurysm of the vena poplitea in his right leg in 2013. Clinical examination revealed blue-to-blackish papules measuring 5-8 mm that were mainly localized on the sole but also on the toes and back of the right foot (Figure 1). The left foot was unremarkable. Phlebological work-up revealed saphenous vein insufficiency of the right lower leg. Histopathology of a skin biopsy showed a dermal capillary proliferation accompanied by a dense infiltrate consisting of lymphocytes, histiocytes and eosinophils and numerous hemosiderin deposits. Most of the vessels were positive for CD31 and negative for D2-40. Immunostaining for human herpesvirus type 8 (HHV-8) was negative, excluding Kaposi sarcoma. Clinicopathological correlation was consistent with a diagnosis of Mali-type acroangiodermatitis. Due to the reported B-symptoms, further diagnostic work-up with abdominal and thoracic computed tomography (CT) was performed, revealing an enlarged, atypical lymph

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Epithelioid angiosarcoma arising from a frontoparietal arteriovenous malformation

Cited by 6 publications

References 0 publications

A female patient with a receding hairline

A female patient with a receding hairline

Possible malignant transformation of arteriovenous malformation to angiosarcoma: case report and literature review

Diagnostic workup of acroangiodermatitis of Mali (pseudo‐Kaposi sarcoma) demasking metastasized epithelioid angiosarcoma

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