Epithelioid cell variant of renal angiomyolipoma

Mai, Kien; Perkins, D. Garth; Collins, John P.

doi:10.1046/j.1365-2559.1996.d01-421.x

Cited by 116 publications

(72 citation statements)

References 4 publications

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“…Different human oncopathological studies described that the renal angiomyolipoma (monotypic, epitheloid variant of the angiomyolipoma) showed HMB45 positivity (Mai et al, 1996;Eble et al, 1997;Pea et al, 1998), but the cutaneous angiomyolipoma was negative for this melanogenesis marker (Mentzel, 2001;Beer, 2005;Makino et al, 2006). Similarly to human dermatological cases, in our case report the smooth-muscle component of the cutaneous angiomyolipoma from the budgerigar showed negativity for HMB45.…”

Section: Discussionsupporting

confidence: 70%

A case of cutaneous angiolipoleiomyoma (angiomyolipoma) in a budgerigar (Melopsittacus undulatus)

et al. 2013

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We report a case of cutaneous angiolipoleiomyoma (angiomyolipoma) found on the anterior wall of the ventral part of the abdomen of a three-year-old female budgerigar (Melopsittacus undulatus). Histologic examination of the well-circumscribed, surgically removed tumour (1.5 cm in diameter) showed a benign admixed proliferation of blood vessels of different size, smooth muscle bundles, and mature adipose tissue, without evidence of malignancy. Endothelial cells of the haemangioma component were positive for claudin-5 endothelium-specific immunohistochemical marker, and the leiomyoma component was positive for α-smooth muscle actin. The differentiated lipocytes showed S-100 protein positivity. The Ki-67 labelling index was 2 to 3%. The mesenchymal tumour was negative for HMB45 melanocytic immunhistochemical marker. To the best of our knowledge, this is the first report describing a cutaneous angiolipoleiomyoma in a budgerigar with histological and immunohistochemical analyses.

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Section: Discussionsupporting

confidence: 70%

A case of cutaneous angiolipoleiomyoma (angiomyolipoma) in a budgerigar (Melopsittacus undulatus)

et al. 2013

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“…Recent reports have considerably widened the spectrum of PEC lesions reporting them in the uterus, pancreas and in the falciform ligament (7)(8)(9)(10)(11). PEC tumors can mimic renal clear cell carcinoma (12)(13)(14)(15)(16)(17) epithelioid leiomyosarcoma (18), hepatocellular carcinoma (19,20) conventional leiomyosarcoma or other high grade sarcomas.…”

Section: Discussionmentioning

confidence: 99%

Abdominopelvic Sarcoma of Perivascular Epithelioid Cells. Report of Four Cases in Young Women, One with Tuberous Sclerosis

et al. 2001

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The perivascular epithelioid cell has been proposed to be the unifying proliferating cell type in a number of lesions such as angiomyolipoma, lymphangiomyomatosis, clear cell "sugar" tumor and renal capsuloma. With the exception of rare examples of angiomyolipoma, they are nonmetastasizing. We report four examples of a new member of this family of perivascular epithelioid cell neoplasms that occur in abdominopelvic location and show metastatic properties. The patients, all women, were aged 19 to 41 years (mean, 32), and presented with a tumor mass involving the serosa of the ileum, uterus or pelvic cavity. Morphologically, the tumors were composed of sheets of large polygonal cells with glycogen-rich clear or eosinophilic cytoplasm and moderately pleomorphic nuclei, traversed by a delicate vasculature, mimicking clear cell carcinoma. There were areas of coagulative necrosis and occasional mitotic figures. Intracytoplasmic brown pigment was present in two cases. Spindly cells, smooth muscle and fat were absent. Lymphovascular invasion was present in all, lymph node metastasis was documented in two and metastasis to the ovary was present in one case. Two patients developed widespread metastatic disease after 10 and 28 months from diagnosis. One patient showed the clinical signs of tuberous sclerosis. In spite of the epithelial-like appearance, the tumor cells were negative for epithelial markers but were strongly positive with the melanogenesis-related marker HMB45. Another melanogenesis marker (MART-1) was positive in two cases. Other markers including S-100 protein, vimentin, muscle-specific actin, desmin and chromogranin A were negative. Thus, these tumors are not readily classifiable in the existing schema of known entities, and show overlapping morpho-phenotypic features of clear cell "sugar" tumor of the lung and epithelioid angiomyolipoma. We consider them as sarcomas composed of a pure population of uncommitted perivascular epithelioid cell, that lack modulation toward smooth muscle or adipose cells.

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“…Although most angiomyolipomas are composed of fat, smooth muscle, and abnormal blood vessels, the morphologic spectrum has been recently expanded with the recognition of the monotypic epithelioid variant (38,(41)(42)(43). These tumors have a striking resemblance to renal-cell carcinoma and often have high-grade histologic features, such as mitotic activity, pleomorphism, and necrosis.…”

Section: Discussionmentioning

confidence: 99%

“…There is strong evidence that angiomyolipomas, for a long time considered to be hamartomatous, are actually neoplasms (39,40). The morphologic spectrum of angiomyolipoma has been recently expanded to include an epithelioid variant, which is capable of a more aggressive behavior than the classic form (41)(42)(43). Further, the recent description of the perivascular epithelioid cell family of tumors (44), to which angiomyolipoma belongs, has expanded our knowledge of entities that would fall into the differential diagnosis of angiomyolipoma and renal-cell neoplasms.…”

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confidence: 99%

Concurrent Angiomyolipoma and Renal Cell Neoplasia: A Study of 36 Cases

et al. 2001

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Little is known about the association of angiomyolipoma and adult renal-cell neoplasia. We studied the clinicopathologic features of 36 patients with concurrent angiomyolipoma and renal-cell neoplasia from the consultation and surgical pathology files of nine institutions. HMB-45 immunoreactivity was analyzed in both neoplasms. Twenty-five sporadic cases of patients with angiomyolipoma and renal-cell neoplasia and 11 cases of patients with tuberous sclerosis, as defined by Gomez' criteria, had mean ages of 59 and 53 years, respectively, and female-male ratios of 2:1 and 5:1, respectively. The mean size of the angiomyolipomas was 1 cm in the sporadic cases and 3 cm in those patients with tuberous sclerosis (medians: 0.5 and 3 cm, respectively, P ‫؍‬ .002). The mean sizes of the renal-cell neoplasms were 5 cm in sporadic cases and 6 cm in patients with tuberous sclerosis (medians: 4 and 5 cm, respectively; P ‫؍‬ .88). In both clinical settings, angiomyolipoma was more commonly the incidental tumor. Clear-cell (conventional) renal-cell carcinoma was the most common renal-cell neoplasm in both groups of patients, accounting for approximately two thirds of the tumors. In patients with tuberous sclerosis, 27% of renal-cell neoplasms were oncocytomas, compared with 8% in sporadic cases (P ‫؍‬ .15). Papillary neoplasia, chromophobe, and collecting-duct renal-cell carcinoma were found only in sporadic cases. All of the 22 renal-cell neoplasms studied were negative for HMB-45, whereas all 25 angiomyolipomas studied were positive.

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Epithelioid cell variant of renal angiomyolipoma

Cited by 116 publications

References 4 publications

A case of cutaneous angiolipoleiomyoma (angiomyolipoma) in a budgerigar (Melopsittacus undulatus)

A case of cutaneous angiolipoleiomyoma (angiomyolipoma) in a budgerigar (Melopsittacus undulatus)

Abdominopelvic Sarcoma of Perivascular Epithelioid Cells. Report of Four Cases in Young Women, One with Tuberous Sclerosis

Concurrent Angiomyolipoma and Renal Cell Neoplasia: A Study of 36 Cases

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