Epithelioid haemangiosarcoma of the thyroid gland. Report of six cases from a non‐Alpine region

Abstract

Although thyroid HAS is usually regarded as an extremely aggressive neoplasm with a dismal prognosis similar to anaplastic carcinoma, one of our cases suggests that HAS can behave in a less aggressive way. The morphological, immunohistochemical and ultrastructural findings support the hypothesis that thyroid HAS is a distinct entity, unrelated to other thyroid malignancies.

Primary angiosarcoma of the thyroid gland in an young Iranian woman

“…Our case had no history of nodular goitre and her thyroid function tests were within normal limits. Thyroid angiosarcoma is more common in the Alpine region or Europe and its incidence is about 2–10% 8. Cases are sporadic in other regions of the world and the exact incidence is unknown 9.…”

“…Angiosarcoma of the thyroid is a primary malignant tumour in the thyroid showing evidence of endothelial differentiation 7. It is a rare tumour and represents 2–10% of thyroid malignancies 8. Angiosarcoma of the thyroid was originally described by Swiss authors as early as 90 years ago in patients from Alpine region 9–11.…”

Vascular Proliferation of the Thyroid: Potential Histopathological Pitfalls as a Consequence of Fine Needle Aspiration

“…Table 1 represents a literature review of thyroid haemangiomas. Outside the endemic alpine area, angiosarcomas and malignant haemangioendotheliomas are uncommon [44,45] . Table 2 summarises various non-tumourous vascular lesions, which are not related to FNAB [46][47][48][49] .…”

Update on Anaplastic Thyroid Carcinoma: Morphological, Molecular, and Genetic Features of the Most Aggressive Thyroid Cancer

“…Primary sarcomas simulating a sarcomatoid ATC have been reported as case reports: fibrosarcoma [13], leiomyosarcoma [14], chondrosarcoma [15], osteosarcoma [16], and angiosarcoma (including epithelioid variant) [17, 18]. Metastases are possible as well and should be clinically ruled-out [19–21].…”