Epithelioid Hemangioendothelioma of the Lower Limb, Discovered by a Claudication

Response by Jung et al to Letter Regarding Article, “Sustained Activation of Endothelial YAP1 Causes Epithelioid Hemangioendothelioma”

“…Intraluminal tumors, including intravascular epithelioid hemangioendothelioma, are often misdiagnosed but provide an uncommon explanation of vessel thrombosis-a common clinical presentation. [18][19][20][21] Our retrospective analysis of pathological lung tissue with intravascular occlusive tumors arising from endothelial cells of the pulmonary artery revealed round and oval cells with abundant pale eosinophilic cytoplasm and prominent cytoplasmic vacuolization (Figure [A] in the study by Jung et al), 16 consistent with Weiss and Enzinger's 1 description of intravascular epithelioid hemangioendothelioma.…”