Epithelioid osteosarcoma of the mandible: a rare case with unusual immunoprofile

A Large Multifocal Aggressive Osteoblastoma of Mandible: an Immunohistochemistry Case Study Report

“…Although our case histologically showed epithelioid-shaped osteoblast cells, CK was negative as reported by Lennart Angervall and Román Carlos et al 9,14 Epithelioid cell is a morphological term, and the cells do not necessarily express CK. 14 Since origin and differentiation of osteoblasts differs from epitheloid cells, we believe the term “Epitheloid” has been used erroneously in the literature.…”

“…14 Since origin and differentiation of osteoblasts differs from epitheloid cells, we believe the term “Epitheloid” has been used erroneously in the literature. Pubmed search revealed no reports of aggressive osteoblastoma with CK immunohistochemical evaluation.…”

A primary vertebral epithelioid osteosarcoma in middle age adult

“…Although the immunophenotypic expression of epithelioid tumor cells is variable in previous literature review, [2][3][4][5][6][7][8] the epithelioid tumor cells of the study case were strongly positive for vimentin, and focal positivity for HMW-CK, EMA and S-100 protein, but negative for LCA, HMB45 and MDM2. The treatment of osteosarcoma is a combination of surgery, chemotherapy, and radiation therapy, but surgical excision was a mainstay of our treatment.…”

“…[3][4][5] However, only one previous primary epithelioid osteosarcoma in the spine was described, presented the clinic-pathological findings. The age and sex of this previously case (49-year-old man) was similar to this case.…”

Primitive Myxoid Mesenchymal Tumor of Infancy With Rosettes

“…Low-grade fibromyxoid sarcoma is the only nonneural soft tissue tumor that often shows rosettes (ie, hyalinizing spindle cell tumor with giant rosettes), of which the core is composed of collagen; the presence of rosettes in our case supports its relationship with the fibrosarcoma family. Rare cases of other nonneural sarcomas with rosettes have been reported, including synovial sarcoma 7,8 and osteosarcoma 9,10. …”