Epithelioid Trophoblastic Tumor: An Outcome-Based Literature Review of 78 Reported Cases

Zhang, Xiaofei; Lü, Weiguo; Lü, Bingjian

doi:10.1097/igc.0b013e31829ea023

Cited by 59 publications

(67 citation statements)

References 29 publications

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“…Lung is the most commonly described extrauterine site of ETT, accounting for 19% of cases; however, our series demonstrates two patients with intra-abdominal extrauterine disease involving the peritoneum and one patient with primary disease found in abdominal wall of a cesarean section scar [14,[18][19][20]. While it is difficult to comment on prognosis in a small case series, extrauterine disease appears to be the most important prognostic factor.…”

Section: Discussionmentioning

confidence: 86%

Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center

Davis

Howitt

Quade

et al. 2015

Gynecologic Oncology

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Section: Discussionmentioning

confidence: 86%

Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center

Davis

Howitt

Quade

et al. 2015

Gynecologic Oncology

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“…Notably, Case 2 showed involvement of the endocervical mucosa, which is a typical growth pattern in ETT. Our previous meta-analysis study showed that about 45% ETTs arose in the lower uterine segment/ cervix (5). However, we did not think that these cases were essentially ETT as they were not cellular lesions showing only scant viable cells at the tumor periphery.…”

Section: Discussionmentioning

confidence: 72%

“…It has been well documented that both ETT and PSTT are resistant to combination chemotherapy (4,5,7). Some intermediate trophoblast tumors were possibly associated with prior chemotherapy (8,(19)(20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathologic Analysis of Postchemotherapy Gestational Trophoblastic Neoplasia: An Entity Overlapping With Epithelioid Trophoblastic Tumor

Lü

Zhang

Liang

2016

International Journal of Gynecological Pathology

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Surgery is generally not required for the majority of gestational trophoblastic neoplasias (GTNs) because they are potentially curable by chemotherapy alone. The histologic assessment is rarely available although the identification of a specific subtype of GTN is relevant to clinical intervention and prognostic prediction. In this study, we analyzed the clinicopathologic features of 4 postchemotherapy GTNs. They presented as a persistent uterine (Cases 1, 2, and 3) or pelvic mass (Case 4) with a raised serum β-hCG level after multiple courses of chemotherapy. All patients were alive without evidence of disease at follow-up periods of 58 to 109 mo after surgery and salvage chemotherapy except for Case 4 which had a recurrent pelvic mass. These GTNs had a characteristic histopathologic pattern of extensive necrosis and a rim of scant viable mononucleated tumor cells at the periphery of the lesion. Immunostaining showed that these tumor cells had a lower Ki67 index than choriocarcinoma, and epithelioid trophoblastic cell tumor although they exhibited an epithelioid trophoblastic cell tumor-like immunostaining pattern (CD146, hPL, and p63). A small number of β-hCG-positive multinucleated trophoblastic cells were also present in 3 of the 4 cases. We suggest that these postchemotherapy GTNs may represent a "snap shot" of the hypothetical choriocarcinoma-epithelioid trophoblastic cell tumor transition. Our findings should provide insights into the pathogenesis of GTNs.

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“…There are only 2 cases of ovarian localizations, one of which presented with pulmonary metastases (Table 1). 2,7,[11][12][13][14] Epithelioid trophoblastic tumor exhibits a nodular growth of medium-sized tumor cells arranged in nests or cords to large masses. Deposition of eosinophilic hyalinelike material is characteristically present in the center of tumor nests or between tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Extrauterine Epithelioid Trophoblastic Tumor Arising in the Ovary With Multiple Metastases

et al. 2015

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Epithelioid trophoblastic tumor is a neoplasm of the chorionic-type intermediate trophoblasts. It is considered a rare gestational trophoblastic disease and is frequently misdiagnosed as carcinoma. Extrauterine epithelioid trophoblastic tumor has been reported in multiple anatomical sites. We report a case of a 50-year-old woman who presented with abdominal pain and distension. Her initial β-human chorionic gonatotropin level was 806.7 IU/L. Imaging showed a large complex ovarian mass with peritoneal and subcapsular hepatic deposits as well as pulmonary nodules. Morphological features of the tumor and its immunohistochemical reactivity to CK8/18, CK7, p63, and CD10 were consistent with the diagnosis of an extrauterine epithelioid trophoblastic tumor arising from the ovary. The differential diagnoses, including other ovarian tumors, were ruled out on the basis of morphology and negative immunostaining to a relatively extended panel of antibodies. A prolonged follow up of these cases and the recognition of such rare tumors in unusual sites are crucial to the diagnosing pathologist and treating physician.

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Epithelioid Trophoblastic Tumor: An Outcome-Based Literature Review of 78 Reported Cases

Cited by 59 publications

References 29 publications

Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center

Epithelioid trophoblastic tumor: A single institution case series at the New England Trophoblastic Disease Center

Clinicopathologic Analysis of Postchemotherapy Gestational Trophoblastic Neoplasia: An Entity Overlapping With Epithelioid Trophoblastic Tumor

Extrauterine Epithelioid Trophoblastic Tumor Arising in the Ovary With Multiple Metastases

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