Epithelioid trophoblastic tumor and its diagnostic dilemmas: A rare case report

Madhu, B; Gerbi, Rada; Nabila, Rasool

doi:10.1016/j.gynor.2011.12.003

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…(3) Her presentation of nodules in the lungs, liver, mesentery, para-aortic lymph nodes, and eventually spleen, without evidence of disease in the uterus, remained unusual for GTD. Nonetheless, there are several case reports of ETT presenting in unusual locations including the lungs [ 5 , 11 ], with unremarkable reproductive organs. (4) On light microscopy, the malignant cells resembled those seen in ETT, having large epithelioid cells with abundant eosinophilic cytoplasm and large areas of necrosis.…”

Section: Resultsmentioning

confidence: 99%

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Microsatellite Genotyping to Distinguish Somaticβ-HCG Secreting Carcinoma from Epithelioid Trophoblastic Tumor

Brett

Sur

Daya

et al. 2015

Case Reports in Pathology

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Objective. Morphologically, β-HCG secreting somatic carcinoma can be difficult to distinguish from epithelioid trophoblastic tumors (ETT). However, their distinction is critical due to their potentially differing prognoses and choice of chemotherapy. Presence of biparental alleles in ETT can be identified with molecular testing. We describe a patient who presented with metastatic carcinoma and elevated serum β-HCG and contrast this to an ETT in another patient. Data and Results. A 32-year-old female with recent possible miscarriage presented with pulmonary emboli and was found to have an increased serum β-HCG, a retroduodenal mass, and multiple nodules in her lungs, liver, and para-aortic lymph nodes. Biopsy showed a β-HCG and p63 positive epithelioid neoplasm with otherwise noncontributory immunohistochemistry. Molecular testing for biparental alleles in repeated length polymorphisms was negative, consistent with somatic origin. The second patient was a 35-year-old pregnant female with increased serum β-HCG and a uterine epithelioid tumor positive for β-HCG. Clinical and pathologic findings were characteristic of ETT and molecular testing was not required. These 2 cases illustrate that β-HCG secreting tumors of different etiologies may have similar appearances, and when clinical and/or IHC findings are inconclusive, molecular testing may be useful.

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Section: Resultsmentioning

confidence: 99%

“…Their distinction is critical due to differing treatment options. ETT can be surgically and medically managed with hysterectomy and chemotherapy (etoposide, methotrexate, dactinomycin, cyclophosphamide, and vincristine) [ 5 ], although those with metastatic disease tend to be less responsive to conventional chemotherapy options [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Microsatellite Genotyping to Distinguish Somaticβ-HCG Secreting Carcinoma from Epithelioid Trophoblastic Tumor

Brett

Sur

Daya

et al. 2015

Case Reports in Pathology

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“…Tab. 1 compares the intervals from antecedent pregnancies in several case reports of ETT before 2016 (1,(3)(4)(5)9,10) . Tab.…”

Section: Discussionmentioning

confidence: 99%

“…Most cases of ETT occur in women who are of reproductive age and have a prior gestational history. The reported interval between the previous gestation and the diagnosis of the tumor ranges from 0 to 264 months (mean, 84 months) (3)(4)(5) . ETT found in the immediate postpartum period is extremely rare; it has been reported only once previously (5) .…”

Section: Introductionmentioning

confidence: 99%

Przypadkowe rozpoznanie nowotworu nabłonkowatokomórkowego trofoblastu bezpośrednio po porodzie – opis przypadku

Kwon

Park

2016

Curr. Gynecol. Oncol.

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Epithelioid trophoblastic tumor is a rare malignant lesion of gestational trophoblastic disease, and constitutes an abnormal proliferation of placental trophoblasts. Patients with epithelioid trophoblastic tumor are usually of reproductive age, and have had previous gestations including full-term deliveries, molar pregnancies and abortions. The interval between antecedent gestational events and the diagnosis of epithelioid trophoblastic tumor usually ranges from 0 to 264 months (mean, 84 months). Herein, we report a 42-year-old Korean woman (gravida 2, para 2). At 38 weeks of gestation, she underwent a repeat cesarean section and then hysterectomy due to uterine atony. She was incidentally diagnosed with epithelioid trophoblastic tumor, and postoperatively no metastatic disease was observed. The patient presented no clinical evidence of tumor recurrence for 5 years after surgery. This case is remarkable because epithelioid trophoblastic tumor is a rare disease, and the diagnosis of epithelioid trophoblastic tumor followed immediately after delivery.

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Antineoplastics

2016

Reactions Weekly

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Epithelioid trophoblastic tumor and its diagnostic dilemmas: A rare case report

Abstract: ►This case is an unusual presentation of a rare disease entity. ►The diagnosis of epithelioid trophoblastic tumor can be challenging resulting in delay in diagnosis. ►Epithelioid trophoblastic tumor can have a very aggressive course, especially in metastatic disease.

Cited by 6 publications

References 5 publications

Microsatellite Genotyping to Distinguish Somaticβ-HCG Secreting Carcinoma from Epithelioid Trophoblastic Tumor

Microsatellite Genotyping to Distinguish Somaticβ-HCG Secreting Carcinoma from Epithelioid Trophoblastic Tumor

Przypadkowe rozpoznanie nowotworu nabłonkowatokomórkowego trofoblastu bezpośrednio po porodzie – opis przypadku

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