2022
DOI: 10.1177/10668969221117983
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Epithelioid Trophoblastic Tumor Presenting as an Adnexal Mass: Report of a Diagnostically Challenging Case

Abstract: Epithelioid trophoblastic tumor (ETT) is a rare neoplasm derived from chorionic intermediate trophoblast cells, representing less than 2% of all gestational trophoblastic neoplasms. Classically, ETT presents as a uterine mass in women of reproductive age following a term pregnancy. The time from pregnancy to tumor development varies from months to several years. ETT most often arises in the endometrium, followed by the cervix. Extrauterine ETT are extremely infrequent, with few cases reported in the literature… Show more

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Cited by 3 publications
(5 citation statements)
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“…Metastatic disease may develop in 15–25% of the cases. In recent years, extrauterine ETT without a documented cervical or uterine primary tumour has been reported in various organs, including the lung, vagina, ovary, fallopian tube and peritoneum 1,6,7,20,32 . As illustrated in the current series, three of the four tumours presented at extrauterine sites (two cases in the lung and one in the liver), with ETT as the major differential diagnosis (Table 1).…”
Section: Discussionsupporting
confidence: 52%
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“…Metastatic disease may develop in 15–25% of the cases. In recent years, extrauterine ETT without a documented cervical or uterine primary tumour has been reported in various organs, including the lung, vagina, ovary, fallopian tube and peritoneum 1,6,7,20,32 . As illustrated in the current series, three of the four tumours presented at extrauterine sites (two cases in the lung and one in the liver), with ETT as the major differential diagnosis (Table 1).…”
Section: Discussionsupporting
confidence: 52%
“…In recent years, extrauterine ETT without a documented cervical or uterine primary tumour has been reported in various organs, including the lung, vagina, ovary, fallopian tube and peritoneum. 1,6,7,20,32 As illustrated in the current series, three of the four tumours presented at extrauterine sites (two cases in the lung and one in the liver), with ETT as the major differential diagnosis (Table 1). The fourth patient presented with uterine lesion and extensive peritoneal involvement resulting in a 'frozen pelvis' and omental 'cake'.…”
Section: Discussionmentioning
confidence: 61%
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“…ETT may be confused with squamous cell carcinoma (SCC) because of its frequent involvement of the lower uterine segment, the appearance of epithelioid histologic morphology, positivity for p63 and keratins, and its eosinophilic hyaline material similar to keratin. [31] The expression of P16 is helpful to differentiate ETT and SCC, as the latter is positive whereas ETT is negative. [32] Furthermore, Ki-67 proliferative index is always high (>50%) in SCC which is usually >10% in ETT.…”
Section: Discussionmentioning
confidence: 99%