Epithelium-Free Bladder Wall Graft: Epithelial Ingrowth and Regeneration—Clinical Implications for Partial Cystectomy

Thangappan, Ravikumar; Eandi, Jonathan A.; Modi, Jay; Kurzrock, Eric A.

doi:10.1016/j.juro.2011.12.014

Cited by 1 publication

(2 citation statements)

References 21 publications

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“… Other autologous tissue (Table 4) Thangappan et al. successfully performed augmentation cystoplasty in 12 rats using de-epithelialized bladder wall grafts, although chronic inflammation as well as residual donor urothelial cells were found [49]. Although augmentation with live-related-donor bladder grafts in rats showed promising results, transferring this particular two-step procedure to humans appeared difficult, as stated by Yamataka et al.…”

Section: Clinical Presentation and Issuesmentioning

confidence: 99%

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Bladder augmentation in children: current problems and experimental strategies for reconstruction

Langer

Radtke

Györi

et al. 2018

Wien Med Wochenschr

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Bladder augmentation is a demanding surgical procedure and exclusively offered for selected children and has only a small spectrum of indications. Paediatric bladder voiding dysfunction occurs either on a basis of neurological dysfunction caused by congenital neural tube defects or on a basis of rare congenital anatomic malformations. Neurogenic bladder dysfunction often responds well to a combination of specific drugs and/or intermittent self-catheterization. However, selected patients with spinal dysraphism and children with congenital malformations like bladder exstrophy and resulting small bladder capacity might require bladder augmentation. Ileocystoplasty is the preferred method of bladder augmentation to date. Because of the substantial long-and short-term morbidity of augmentation cystoplasty, recent studies have tried to incorporate new techniques and technologies, such as the use of biomaterials to overcome or reduce the adverse effects. In this regard, homografts and allografts have been implemented in bladder augmentation with varying results, but recent studies have shown promising data in terms of proliferation of urothelium and muscle cells by using biological silk grafts.

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Section: Clinical Presentation and Issuesmentioning

confidence: 99%

“…Thangappan et al. successfully performed augmentation cystoplasty in 12 rats using de-epithelialized bladder wall grafts, although chronic inflammation as well as residual donor urothelial cells were found [49].…”

Section: Clinical Presentation and Issuesmentioning

confidence: 99%