Epitheloid haemangioendothelioma of liver: a vascular tumour easily mistaken for metastatic carcinoma on ultrasound imaging

Banerjee, B. D.; Rennison, A.

doi:10.1259/0007-1285-65-775-611

Cited by 14 publications

(6 citation statements)

References 5 publications

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“…Immunohistochemically, an EHE demonstrates a positive result for epithelial markers such as keratins or EMA 2,5 and a negative result for the endothelial markers CD31, CD34, and factor VIII-related antigen. 8 However, it should be noted that a positive result for any of the endothelial markers supports only the vascular origin but not the biologic potential of the lesio. 2,3,6 An EHE primarily involves the visceral organs such as the lung, liver, and brain, as well as bone and soft tissue.…”

Section: Discussionmentioning

confidence: 98%

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Epithelioid Hemangioendothelioma of the Lip: Case Report

Babakurban¹,

Tarhan²,

Aydın³

et al. 2013

Turkish J Rhinology

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ascular tumors range from benign hemangiomas to fully malignant angiosarcomas .1-4 Epithelioid hemangioendothelioma (EHE) are rare vascular tumors of round to polygonal cells with eosinophilic cytoplasm, intracytoplasmic vacuoles and vesicular nuclei. EHEs were first identified by Weiss and Enzinger in 1982 5 as tumors with an indolent course and a potential for recurrence or metastasis. [5][6][7] EHE has been reported in lungs, liver, skin, larynx, lymph nodes, thyroid, stomach, brain and meninges but occurrence in the head and neck is rare. So far, 33 cases involving head and neck region were reported in Eng- We present a 19-year-old male with one week history of an asymptomatic swelling of his right lower lip. Dermatologic examination revealed a 1.5x2.0 cm in diameter, firm-irregular lesion on the mucosal surface of the right lower lip and the presumptive diagnosis was cheilitis glandularis-granulomatosis. He was referred to ENT clinic for biopsy. Histologically, there was an infiltrative tumor composed of epithelioid cells. Histopathological diagnosis was epithelioid hemangioendothelioma. Based on this clinically unexpected diagnosis, he underwent re-excision and a suprahyoid lymph node dissection that showed a small focus of residual tumor but no lymph node metastasis. Three years follow-up showed no recurrence or metastasis.K Ke ey y W Wo or rd ds s: : Epithelioid hemangioendothelioma; head and neck Ö ÖZ ZE ET T Epi te li o id he man ji o en do tel yo ma (EHE) na dir bir tü mör dür. Epi te li o id hüc re le rin pro li feras yo nu ile ka rak te ri ze dir, bu özel li ği vas kü ler or jin li tü mör le rin dik ka te alın ma ma sı du ru mun da güç lü ğe ne den ol mak ta dır. Bu ya zı da sağ alt du da ğın da bir haf ta dır asemp to ma tik şiş li ği olan 19 ya şın da ki er kek has ta su nul muş tur. Der ma to lo jik mu a ye ne sin de sağ alt du dak mu ko za sın da 1.5x2 cm çap la rın da, sert-ir re gü ler kit le tes pit edil miş ve ön ta nı ola rak çey li tis glan du la ris-gar nü lo mato zis dü şü nü le rek bi yop si ama cı ile KBB po lik li ni ği ne re fe re edil miş tir. Bi yop si ma ter ya li nin in celen me sin de epi te li o id hüc re ler den olu şan in fil tra tif bir tu mör ol du ğu gö rül müş tür ve his to pa to lo jik ola rak epi te li o id he man ji o en do tel yo ma ta nı sı ko nul muş tur. Bu kli nik ola rak bek len me yen ta nı üze-ri ne tek rar ek siz yon ve sup ra hi yo id bo yun di sek si yo nu ya pıl mış tır, re zi dü el tu mör ve ya lenf no du me tas ta zı iz len me miş tir. Has ta nın üç yıl lık iz le min de re kür rens ya da me tas taz gö rül me miş tir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Epitelioid hemanjioendotelyoma, baş ve boyun T Tu ur rk ki is sh h J J R Rh hi in no ol lo og gy y 2 20 01 13 3; ;2 2( (1 1) ): :1 1--4 4

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Section: Discussionmentioning

confidence: 98%

“…2,8 We report a case of EHE involving the lip that deceptively presented as a non-tumoral inflammatory lesion.…”

mentioning

confidence: 99%

Epithelioid Hemangioendothelioma of the Lip: Case Report

Babakurban¹,

Tarhan²,

Aydın³

et al. 2013

Turkish J Rhinology

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“…Factors possibly involved in the etiology of EHAE include oral contraceptives (9), vinyl chloride (10), asbestos (11), thorotrast (12), liver trauma (13), viral hepatitis (14), primary biliary cirrhosis (15) and alcohol-related hepatic disorders (6). These findings suggest that inflammation or female hormones may be associated with the development of EHAE.…”

Section: Discussionmentioning

confidence: 99%

Hepatic epithelioid hemangioendothelioma with metastasis to the mesentery of the small intestine: A case report

Nakamura

Adachi

Nakashima³

et al. 2017

Molecular and Clinical Oncology

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Epithelioid hemangioendothelioma (EHAE) is a vascular tumor which, due to its rarity, is often misdiagnosed as other hepatic tumors based on radiological characteristics. We herein report a case of EHAE in the liver and the mesentery of the small intestine. A 64-year-old asymptomatic woman was admitted to the hospital due to a hepatic tumor identified using computed tomography (CT). An enhanced CT scan revealed multiple tumors in the liver and a tumor in the mesentery. One of the hepatic tumors and the mesenteric tumor were resected and histologically examined. The two tumors exhibited similar histological characteristics and were diagnosed as EHAE. When multiple tumors are found in the liver, EHAE should be included in the differential diagnosis, as the prognosis of EHAE differs from that of carcinoma or benign tumors.

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“…13 Our 36-year-old female patient also matches the published demographic findings. There are no clear risk factors for the development of HEH, although oral contraceptives, 14 vinyl chloride, 15 asbestos, 16 thorotrast, 17 major hepatic trauma, 18 and alcohol consumption 19 are known to be contributory agents in HEH pathogenesis. We could not find any risk factor in our patient.…”

Section: Discussionmentioning

confidence: 99%

Primary hemangioendothelioma of liver; report of a case and review of literature

Redaelli

Guraya

2015

Journal of Taibah University Medical Sciences

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Hepatic epithelioid hemangioendothelioma (HEH) is an exceedingly rare tumor of vascular origin with unknown etiology and unpredictable natural course and malignant potential. The disease presents with myriad of vague symptoms and can be diagnosed by ultrasound, CT, and MRI. Target shaped hepatic lesions due to hyperechoic center and hypoechoic peripheral rim are the diagnostic ultrasonic features. Hepatic capsular retractions due to extensive fibrosis can be identified by CT and MRI. The lesions are usually hypointense on T1-weighted images and hyperintense on T2-weighted images. There is no consensus on treatment of hepatic epithelioid hemangioendothelioma, which ranges from hepatic resection, hepatectomy, liver transplantation, chemo-and radiotherapy, and thermoablation. This case report presents a 36-year-old female, incidentally diagnosed to have hepatic epithelioid hemangioendothelioma, which was treated by right hepatectomy and was attended by favorable outcome.

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Epitheloid haemangioendothelioma of liver: a vascular tumour easily mistaken for metastatic carcinoma on ultrasound imaging

Cited by 14 publications

References 5 publications

Epithelioid Hemangioendothelioma of the Lip: Case Report

Epithelioid Hemangioendothelioma of the Lip: Case Report

Hepatic epithelioid hemangioendothelioma with metastasis to the mesentery of the small intestine: A case report

Primary hemangioendothelioma of liver; report of a case and review of literature

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