Epitheloid hemangioma: A report of two cases

Devi, Basanti; Jena, Swapna; Kar, Debjit; Patro, Sibasish; Behera, Binodini

doi:10.4103/0019-5154.139918

Cited by 5 publications

(8 citation statements)

References 9 publications

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“…However, Kimura's disease is marked by serum eosinophilia and hyperimmunoglobulinemia and there is lymph node involvement. 9,10 In the patient described here, characteristics related to Kimura's disease were not present.…”

Section: Discussionmentioning

confidence: 62%

“…In turn, the epithelioid variant of angiosarcoma is a lesion with aggressive clinical behavior, that is infiltrative and destructive, with elevated cellular pleomorphism, in addition to exhibiting presence of mitoses and areas of necrosis. 9 Kimura's disease is the primary entity to consider in differential diagnosis, since both are considered eosinophilic dermatosis and they have morphological similarities. However, Kimura's disease is marked by serum eosinophilia and hyperimmunoglobulinemia and there is lymph node involvement.…”

Section: Discussionmentioning

confidence: 99%

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Hiperplasia angiolinfoide com eosinofilia: um caso raro em cavidade oral

et al. 2016

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Angiolymphoid Hyperplasia with eosinophilia (ALHE) is considered a rare, benign vascular lesion that mainly affects the skin and subcutaneous tissues of the head and neck, but is uncommon in the oral cavity. Its etiology remains unclear and it has been described as a reactive vascular proliferation, vascular malformation or neoplasm. Kimura' s disease is the primary entity to consider in differential diagnosis. Here we report on a rare case of ALHE involving the upper lip of a 50-year-old male patient that had a nodular swelling with approximately 3 cm, 7 years after initial onset. An excisional biopsy was performed and histopathologic examination revealed a well-encapsulated, multi-lobed lesion with proliferation of blood capillaries, displaying endothelial cells of epithelioid appearance, diffuse inflammatory infiltrate with lymphocytes, plasma cells, numerous eosinophils, and presence of lymphoid follicles. Immunohistochemical tests were positive for the markers CD34 and Ki-67 that, in combination with the results of morphological examination, were suggestive of a diagnosis of ALHE.Keywords: vascular system lesions; hemangioma; differential diagnosis. ResumoA hiperplasia angiolinfoide com eosinofilia (HALE) é considerada uma lesão vascular benigna rara que acomete, principalmente, o tecido cutâneo e subcutâneo da região de cabeça e pescoço, mas incomum na cavidade oral. Sua etiopatogenia permanece indefinida, sendo descrita como proliferação vascular reacional, malformação vascular ou neoplasia. Tem como principal diagnóstico diferencial a doença de Kimura. Este trabalho relata um caso de um paciente do sexo masculino, de 50 anos, que exibia aumento de volume nodular na mucosa do lábio superior, com 3 cm de dimensão e 7 anos de evolução. Após a biópsia excisional, o exame histopatológico mostrou lesão bem encapsulada multilobulada com proliferação de capilares sanguíneos com células endoteliais de aspecto epitelioide, infiltrado inflamatório difuso com linfócitos, plasmócitos, inúmeros eosinófilos e presença de folículos linfoides. A análise imuno-histoquímica revelou positividade para CD34 e Ki-67, o que, juntamente com o exame morfológico, direcionou o diagnóstico para HALE.Palavras-chave: lesões do sistema vascular; hemangioma; diagnóstico diferencial.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Hiperplasia angiolinfoide com eosinofilia: um caso raro em cavidade oral

et al. 2016

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“…Epithelioid endothelial cells may have produced an eosinophilic chemotactic factor, and the membranous glomerulopathy may have been secondary to immune complex deposition as a result of the intracardiac tumor considering that about 5% to 10% of membranous glomerulopathy in adults is tumor related. 18,24,27 We cannot exclude the possibility that the intracardiac EH was first related to a systemic disease (nephrotic syndrome and eosinophilia) and was subsequently induced by the tumor as it increased in size.…”

Section: Discussionmentioning

confidence: 99%

“…3,4,8-17 EH is histologically composed of well-formed, but often immature, vessels lined by epithelioid/histiocytoid endothelial cells with a prominent inflammatory component (eosinophils, lymphocytes, plasma, and mast cells). 3,4,8-32…”

Section: Introductionmentioning

confidence: 99%

“…Many of these lesions, whether EH or KD, seem to primarily affect the subcutaneous tissue, while other anatomical locations, including the visceral organs, are rare. 1-27 Furthermore, although patients with EH can present peripheral eosinophilia and a high level of IgE, nephrotic syndrome is uncommon. 3-9 Here, we present a new case of EH in the heart, occurring in a woman with a previously steroid-responsive nephrotic syndrome associated with membranous glomerulonephritis.…”

Section: Introductionmentioning

confidence: 99%

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Epithelioid Hemangioma (Angiolymphoid Hyperplasia With Eosinophilia) of the Heart With Peripheral Eosinophilia and Nephrotic Syndrome

Machado

Chong

Serrano³

et al. 2015

Int J Surg Pathol

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Epithelioid hemangioma (EH) is a rare benign vascular lesion, characterized by endothelial cells with epithelioid/histiocytoid appearance. Heart involvement is extremely rare. We present an unusual case of cardiac EH in a young woman with supraventricular arrhythmia, nephrotic syndrome (membranous glomerulopathy), and peripheral eosinophilia after a pregnancy and normal partum resembling Kimura disease. Echocardiogram showed a large tumor mass in the right cardiac ventricle. The cardiac tumor was removed and the histopathology revealed an endothelial proliferation associated with abundant eosinophils. The neoplastic endothelial cells were eosinophilic and polygonal with epithelioid/histiocytoid morphology. Lymphoid nodules were occasionally seen. The neoplastic cells were positive for CD34, CD31, ERG, and factor VIII and negative for CK. A diagnosis of EH was rendered. The patient was alive and well after surgical resection. EH and Kimura disease represent separate entities, but clinical and/or histological overlapping can be observed. Epithelioid/histiocytoid endothelial cells constitute the hallmark feature that favors a final diagnosis of EH.

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