Epithioandrostanol (10275-S), an Estrogen Antagonist

Oral high-dose medroxyprogesterone acetate (MAP) in treatment of advanced breast cancer

“…A variety of antiestrogens, both nonsteroidal (16) and steroidal (17), have been shown to act by competitive inhibition at specific binding sites of ER in the cytosol of the target cells. When their binding affinity to ER was measured, it was found that the non-steroidal antiestrogen tamoxifen has 0.7-1.0% of E2's affinity (16), and the steroidal epithiostanol also has about 1.0% (17). We demonstrated here that MAP also inhibits estrogen binding to ER in the cytosol of human breast cancer cells, though with lower affinity; the inhibition for binding of E2 to ER was approximately 60% at 10-5 M MAP.…”

Development of a Low Background Environment for the Cryogenic Dark Matter Search

“…The cosmic ray muon flux has two components: a fast, high-energy component and a slow, low-energy component. Miyake [86] gives the following empirical formulae for the integral and differential muon intensities at the earth's surface as a function of zenith angle, 9:…”

“…where ^ is the muon stopping rate at a depth h which can be determined from the well known experimental intensity-depth relation for muons [86], is the fraction of negatively charged muons which can be determined from the measured muon charge ratio [90], f c is the fraction of the stopped muons which are captured by a proton [91] (the rest of the muons decay) and f n is the neutron multiplicity discussed above.…”

“…Once the muon flux has been measured, it can be used to determined the overburden using the empirical formula for the muon flux intensity as a function of the vertical depth (for flat topology) given by Miyake [86]:…”