Epizootic Activity of Natural Plague Foci of the Russian Federation in 2008–2017 and Forecast  for 2018

Попов, Н. В.; Kuznetsov, A. A.; Matrosov, A. N.; Корзун, В. М.; Verzhutsky, D. B.; Vershinin, S. A.; Косилко, С. А.; Innokent’eva, T. M.; Grigor’ev, M. P.; Degtyarev, D. Yu.; Gerasimenko, E. V.; Dubyansky, V. M.; Shilov, M. M.; Toporkov, V. P.; Zenkevich, E. S.; Попов, В. П.; Лопатин, А. А.; Bezsmertny, V. E.; Балахонов, С. В.; Куличенко, А. Н.; Кутырев, Владимир

doi:10.21055/0370-1069-2018-1-50-55

Cited by 9 publications

(9 citation statements)

References 6 publications

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“…In the "desert" period, S. pygmaeus, together with gerbils, was a principal reservoir host of plague disease in Kalmykian rangelands, and plague epizootics were frequent and extensive. Since the mid-1990s they have become rare and sporadic (Popov et al 2018). Obviously, the disappearance of such important keystone species and their burrows can have severe and long-term consequences for rodent pop-ulation connectivity as well as for local ecosystem sustainability and functioning.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it is the main prey for both terrestrial and aerial predators, and, in particular, for the rare and endangered steppe eagle (Aquila nipalensis Hodgson, 1833) in Kalmykia, (Savinetsky & Shilova 1986). All 4 rodent species are natural hosts of plague and other zoonotic infections (Matrosov et al 2003;Popov et al 2018). Previous studies described short-term effects of steppification on the rodent community at initial stages of rangeland recovery in Kalmykia (Shilova et al 2000;Rogovin 2007) or analyzed long-term local changes in abundance of some individual species (the little souslik, S. pygmaeus ] and the midday gerbil, M. meridianus [Tchabovsky et al 2016]) in small study areas with a limited number of survey sites and narrow spectrum of species-specific habitats.…”

Section: Introductionmentioning

confidence: 99%

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Rodent burrow network dynamics under human‐induced landscape transformation from desert to steppe in Kalmykian rangelands

Surkova

Popov

Tchabovsky

2019

Integrative Zoology

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Rodents play an important role in rangelands through the engineering of extensive burrow systems, which provides key habitats for many animal and plant species. We have analyzed the long‐term variation in the abundance and distribution of rodent burrows in grazing ecosystems of southern Russia (Kalmykia) under the landscape change from desert to steppe caused by the drastic reduction of livestock after the collapse of the USSR in the early 1990s. We conducted burrow surveys in the “desert” (1980) and “steppe” (2017) periods on 19 3‐km transects. We found considerable changes in burrow abundance and distribution, as well as evidence of desert habitat fragmentation and isolation caused by the expansion of tall‐grass communities. Burrows of the open‐dwelling diurnal ground squirrel (Spermophilus pygmaeus), the dominant and the keystone species during the “desert” period, almost completely disappeared from the rodent burrow network by 2017, indicating significant habitat loss. In contrast, the burrows of the folivorous social vole (Microtus socialis) which was rare in the 1980s, became abundant and ubiquitously distributed. The burrow density of the desert‐dwelling psammophilous midday gerbil (Meriones meridianus) decreased, while the distances between occupied patches increased, indicating desert habitat fragmentation and loss of population connectivity. Burrows of the folivorous tamarisk gerbils (M. tamariscinus) were recorded only sporadically in both 1980 and 2017. The observed changes in the rodent burrow network, the key component of grazing ecosystems, correlate with rodent species ecology and can have long‐term and important consequences for ecosystem functioning.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rodent burrow network dynamics under human‐induced landscape transformation from desert to steppe in Kalmykian rangelands

Surkova

Popov

Tchabovsky

2019

Integrative Zoology

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“…Fleas and rodents that are common for the Caspian natural sand plague focus often get infected with plague and such epidemics are wide-scale and appear with certain periodicity [1]. As a rule, in the past when an epizootic situation deteriorated drastically in the Caspian sand natural plague focus, the process was accompanied with epidemiological complications [2]. In 2014 it was only timely reacting that allowed preserving epidemiologically favorable situation when there was another wave of epizooties on the territory; this reacting involved timely activities aimed at specific and non-specific plague prevention [2,3].…”

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confidence: 99%

Immunologic monitoring over people vaccinated against plague in caspian sand natural focus in order to assess and manage health risks

Бугоркова¹,

Клюева²,

Кудрявцева³

et al. 2020

Health Risk Analysis

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To provide better opportunities for managing both risks caused by vaccination and risks of epidemiological complications, immunologic monitoring over people vaccinated with live dried plague vaccine (LPV) due to epidemiologic indications was performed. Our research goal was to assess whether immunologic monitoring over people vaccinated against plague yielded informative results; it was done to substantiate activities aimed at improving procedures for LPV application. Immunologic monitoring was performed from 2016 to 2019 in the Caspian sand natural plague focus according to conventional procedures for assessing humoral and cellular components in immunity. We determined immunologic parameters in 217 volunteers vaccinated with LPV and 130 healthy donors (the reference group) prior to and 1 and 12 months after vaccination. We suggested a methodical approach based on aggregated analysis of the summated immune response predictors chosen for estimation in volunteers vaccinated with LPV and giving score values to them; it allows revealing people who react to plague microbe antigens predominantly as per cellular, humoral, or mixed type. Immunologic monitoring results proved that it was safe to apply LPV; they allowed characterizing trends occurring in immunological restructuring in vaccinated volunteers, determining limits of fluctuation in individual parameters of an immune response to the vaccine, and revealing people with both normal and changed (reduced or increased) immunologic reactivity to LPV. If monitoring data are taken into account, it provides an opportunity to predict vaccination results as per epidemiological parameters, to reveal groups with normal, high, or low immune reactivity to plague microbe antigens in order to determine people in them who need an individual approach when it comes down to anti-plague vaccination.

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“…были выявлены эпизоотии чумы среди грызунов, составила боле 1,9 тыс. км 2 [6]. Ситуация осложняется случаями заболевания чумой в сопредельных с Россией государствах, а также вероятностью завоза особо опасного инфекционного заболевания через транспортные и торговые потоки из стран Юго-Восточной Азии.…”

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An association between parameters of Th1 and Th2 cell-related functional activity and HLA gene polymorphism in individuals after anti-plague vaccination

Кудрявцева¹,

Бугоркова²,

Щуковская³

et al. 2019

Russian Journal of Infection and Immunity

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In theRussian Federation, Y. pestis NIIEG strain-based live attenuated vaccine is used for immunization against plaque on epidemiological indications, displaying high efficiency. However, individual fluctuations in adaptive immunity after vaccination necessitate conducting a search for genes underlying variability of developing immune response. Of note, HLA (Human Leukocyte Antigen) gene polymorphism plays an important role in this process. In our study, we identified HLA class II haplotypes for HLA-DRB1, HLA-DQA1, and HLA-DQB1 in 120 residents of theterritoryofPre-Caspiannatural plague focus, who were immunized against plague. In addition, level of TNFα production correlated with detecting allelic groups HLA-DRB1*04 (р = 0.05) and DRB1*12 (р = 0.01). The data obtained show that HLA class II gene polymorphism can affect the level of cytokine secretion in response to plague immunization. Examining the genes regulating immune factor production will allow to get better insight into the mechanisms underlying immune response variations after vaccination as well as contribute to predicting immunogenicity and efficiency of developing vaccine preparations.

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Epizootic Activity of Natural Plague Foci of the Russian Federation in 2008–2017 and Forecast for 2018

Cited by 9 publications

References 6 publications

Rodent burrow network dynamics under human‐induced landscape transformation from desert to steppe in Kalmykian rangelands

Rodent burrow network dynamics under human‐induced landscape transformation from desert to steppe in Kalmykian rangelands

Immunologic monitoring over people vaccinated against plague in caspian sand natural focus in order to assess and manage health risks

An association between parameters of Th1 and Th2 cell-related functional activity and HLA gene polymorphism in individuals after anti-plague vaccination

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