Epizootiology of Tacaribe Serocomplex Viruses (Arenaviridae) Associated with Neotomine Rodents (Cricetidae, Neotominae) in Southern California

Louise, MilazzoMary; CajimatMaria, N B; Mauldin, Matthew R.; BennettStephen, G; HessBarry, D; RoodMichael, P; ConlanChristopher, A; NguyenKiet,; Wakoli, WekesaJ.; RamosRonald, D; BradleyRobert, D; FulhorstCharles, F

doi:10.1089/vbz.2014.1625

Cited by 7 publications

(2 citation statements)

References 32 publications

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“…Evidence of mammarenavirus infection in rodents, bats and humans within the Americas has been previously documented in the USA, Columbia, Brazil and French Guiana [54][55][56][57][58][59][60][61][62][63][64][65]. A mammarenavirus seroprevalence rate of 2.5% was observed among wild rodents in Barbados during this study, which is comparable to seroprevalence rates observed in wild rodents from Turkey (2.4%), Italy (5.6%), the United Kingdom (5.8%) and the USA (3.1%) [66][67][68][69].…”

Section: Mammarenavirus Ifa Seropositive Rodentsmentioning

confidence: 99%

Serological Evidence of Multiple Zoonotic Viral Infections among Wild Rodents in Barbados

et al. 2021

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Background: Rodents are reservoirs for several zoonotic pathogens that can cause human infectious diseases, including orthohantaviruses, mammarenaviruses and orthopoxviruses. Evidence exists for these viruses circulating among rodents and causing human infections in the Americas, but much less evidence exists for their presence in wild rodents in the Caribbean. Methods: Here, we conducted serological and molecular investigations of wild rodents in Barbados to determine the prevalence of orthohantavirus, mammarenavirus and orthopoxvirus infections, and the possible role of these rodent species as reservoirs of zoonotic pathogens. Using immunofluorescent assays (IFA), rodent sera were screened for the presence of antibodies to orthohantavirus, mammarenavirus (Lymphocytic choriomeningitis virus—LCMV) and orthopoxvirus (Cowpox virus—CPXV) infections. RT-PCR was then conducted on orthohantavirus and mammarenavirus-seropositive rodent sera and tissues, to detect the presence of viral RNA. Results: We identified antibodies against orthohantavirus, mammarenavirus, and orthopoxvirus among wild mice and rats (3.8%, 2.5% and 7.5% seropositivity rates respectively) in Barbados. No orthohantavirus or mammarenavirus viral RNA was detected from seropositive rodent sera or tissues using RT–PCR. Conclusions: Key findings of this study are the first serological evidence of orthohantavirus infections in Mus musculus and the first serological evidence of mammarenavirus and orthopoxvirus infections in Rattus norvegicus and M. musculus in the English-speaking Caribbean. Rodents may present a potential zoonotic and biosecurity risk for transmission of three human pathogens, namely orthohantaviruses, mammarenaviruses and orthopoxviruses in Barbados.

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Section: Mammarenavirus Ifa Seropositive Rodentsmentioning

confidence: 99%

Serological Evidence of Multiple Zoonotic Viral Infections among Wild Rodents in Barbados

et al. 2021

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“…An exception is Tacaribe virus (TCRV) that infects Artibeus bats and may be vectored by insects [4]. NW arenaviruses from Northern America infect rodents from the subfamily Neotominae, whereas those from Latin American and the Caribbean infect rodents from the subfamiliy Sigmodontinae [5,6]. Old World (OW) arenaviruses are found in African rodents from the family Muridae subfamily Murinae [7,8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Proteomics Computational Analyses Suggest that the Antennavirus Glycoprotein Complex Includes a Class I Viral Fusion Protein (α-Penetrene) with an Internal Zinc-Binding Domain and a Stable Signal Peptide

Garry

2019

Viruses

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A metatranscriptomic study of RNA viruses in cold-blooded vertebrates identified two related viruses from frogfish (Antennarius striatus) that represent a new genus Antennavirus in the family Arenaviridae (Order: Bunyavirales). Computational analyses were used to identify features common to class I viral fusion proteins (VFPs) in antennavirus glycoproteins, including an N-terminal fusion peptide, two extended alpha-helices, an intrahelical loop, and a carboxyl terminal transmembrane domain. Like mammarenavirus and hartmanivirus glycoproteins, the antennavirus glycoproteins have an intracellular zinc-binding domain and a long virion-associated stable signal peptide (SSP). The glycoproteins of reptarenaviruses are also class I VFPs, but do not contain zinc-binding domains nor do they encode SSPs. Divergent evolution from a common progenitor potentially explains similarities of antennavirus, mammarenavirus, and hartmanivirus glycoproteins, with an ancient recombination event resulting in a divergent reptarenavirus glycoprotein.

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Arenaviruses and Hemorrhagic Fevers: From Virus Discovery to Molecular Biology, Therapeutics, and Prevention in Latin America

Romanowski

Pidre

Lozano

et al. 2017

Human Virology in Latin America

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Epizootiology of Tacaribe Serocomplex Viruses (Arenaviridae) Associated with Neotomine Rodents (Cricetidae, Neotominae) in Southern California

Abstract: The objective of this study was to advance our knowledge of the epizootiology of Bear

Cited by 7 publications

References 32 publications

Serological Evidence of Multiple Zoonotic Viral Infections among Wild Rodents in Barbados

Serological Evidence of Multiple Zoonotic Viral Infections among Wild Rodents in Barbados

Proteomics Computational Analyses Suggest that the Antennavirus Glycoprotein Complex Includes a Class I Viral Fusion Protein (α-Penetrene) with an Internal Zinc-Binding Domain and a Stable Signal Peptide

Arenaviruses and Hemorrhagic Fevers: From Virus Discovery to Molecular Biology, Therapeutics, and Prevention in Latin America

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