Abstract:High‐risk neuroblastoma (NB) is one of the most aggressive childhood tumors that lacks effective treatment. Targeted drugs, such as receptor tyrosine kinase (RTK) inhibitors, have shown potential in treating high‐risk NB, but their efficacy is likely impaired by the cancer cells’ ability to adapt to drugs. Unlike other cancers, NB has a very low frequency of recurrent mutations, and only a few of them, such as MYCN amplification, can be used as prognostic markers. Here we reasoned that activation of growth fac… Show more
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