EPR study of the effect, induced by zidovudine (AZT), on the membrane lipid dynamics in leukemic cell

Colacicchi, S.; Carnicelli, Veronica; Giulio, Antonio Di; Gualtieri, G. J.

doi:10.1163/156856702320267145

Res. Chem. Intermed.

2002

DOI: 10.1163/156856702320267145

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EPR study of the effect, induced by zidovudine (AZT), on the membrane lipid dynamics in leukemic cell

S. Colacicchi¹,

Veronica Carnicelli²,

Antonio Di Giulio³

et al.

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2015

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Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2

Carnicelli¹,

Lizzi²,

Gualtieri³

et al. 2015

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Azidothymidine (AZT) is one of the anti-retroviral drugs currently used for the treatment of HIV-infected patients. Several other effects of the drug have been studied in vitro, such as the alterations of some enzymes, the inhibition of cell proliferation, and the increase of transferrin receptor expression. In this study, we investigated the alterations of protein kinase C (PKC) activity, PKCα and PKCβII expressions and plasmatic membrane fluidity induced by AZT in two cancer cell lines, human chronic myeloid (K562) and human acute lymphoblastic (HSB-2) leukemia cells, respectively. The results showed that both PKC activity and membrane fluidity in HSB-2 cells increased after 24 h of drug incubation. PKCα expression in HSB-2 cells decreased after 48 h of AZT exposure, when the cell growth also decreased. However, in K562 cells, the PKCα and PKCβII expressions enhanced in the presence of the drug when the growth was inhibited. The results indicate that AZT is less effective in inhibiting the growth of acute lymphoblastic HSB-2 leukemia cells than inhibiting that of chronic myeloid K562 cells. In fact, after 24 h exposure, the HSB-2 cell growth decreased less than K562 cell growth.

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Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2

Carnicelli¹,

Lizzi²,

Gualtieri³

et al. 2015

ABBS

View full text Add to dashboard Cite

show abstract

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EPR study of the effect, induced by zidovudine (AZT), on the membrane lipid dynamics in leukemic cell

Cited by 1 publication

References 17 publications

Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2

Effects of azidothymidine on protein kinase C activity and expression in erythroleukemic cell K562 and acute lymphoblastic leukemia cell HSB-2

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