Eprosartan-Based Hypertension Therapy, Systolic Arterial Blood Pressure and Cognitive Function: Analysis of Middle East Data From the Oscar Study

Radaideh, Ghazi Ahmad; Choueiry, Patrick; Eid, E.; Ismail, Anas; Berrou, J-P.; Sedefdjian, A.; Sévenier, F.; Pathak, Atul

doi:10.1097/00004872-201106001-01680

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…The initial results showed that MMSE scores were significantly increased compared to baseline after Eprosartan treatment (+ 0.8 points; P < 0.0001) [47]. In a subsequent study, [48] it was shown that, in addition to lowering BP, Eprosartan treatment reduced pulse pressure, suggesting that AT1 receptor antagonists may reduce arterial stiffness and contribute to cognitive improvement.…”

Section: Angiotensin II Receptor Blockers (Arbs)mentioning

confidence: 97%

Effects of Antihypertensive Drugs on Cognitive Function in Elderly Patients with Hypertension: A Review

Yang

Luo

et al. 2021

Aging and disease

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Hypertension is a common comorbidity that contributes to the development of various cardiovascular disorders in elderly patients. Moreover, hypertension has been associated with cognitive decline and dementia. Cognitive impairment leads to increased morbidity and mortality in elderly patients with hypertension. However, previous studies investigating the association between blood pressure (BP), BP variability (BPV), and antihypertensive drug use and the risk of cognitive impairment in elderly patients with hypertension have reported inconsistent findings. Given the global burden of hypertension, the aging population, and the low quality of life associated with cognitive impairment, a more comprehensive understanding of the association between hypertension and cognitive decline is needed. In this review, we summarized the current preclinical evidence and clinical research regarding the association of BP control, BPV, and antihypertensive drug use and cognitive function. We particularly focused on the differences among categories of antihypertensive drugs. We concluded that the correlation of BP and risk of cognitive function is non-linear and dependent on a patient's age. Intensive BP control is generally not recommended, particularly for the oldest-old. Increased BPV and characteristics of orthostatic hypotension in the elderly also increase the risk of cognitive decline. The current evidence does not support one category of antihypertensive drugs as superior to others for preventing dementia in elderly patients with hypertension.

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Section: Angiotensin II Receptor Blockers (Arbs)mentioning

confidence: 97%

Effects of Antihypertensive Drugs on Cognitive Function in Elderly Patients with Hypertension: A Review

Yang

Luo

et al. 2021

Aging and disease

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“…Furthermore, increased arterial stiffness is a significant predictor of subsequent cognitive decline [63]. Conversely, intervention studies have shown that drugs that can lower arterial stiffness have positive effects on cognitive function [64]. Neuroimaging studies have shown associations between aortic stiffness and measures of brain integrity.…”

Section: Klohsmentioning

confidence: 99%

An Integrated View on Vascular Dysfunction in Alzheimer’s Disease

Klohs

2019

Neurodegener Dis

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Background: Cerebrovascular disease is a common comorbidity in patients with Alzheimer's disease (AD). It is believed to contribute additively to the cognitive impairment and to lower the threshold for the development of dementia. However, accumulating evidence suggests that dysfunction of the cerebral vasculature and AD neuropathology interact in multiple ways. Vascular processes even proceed AD neuropathology, implicating a causal role in the etiology of AD. Thus, the review aims to provide an integrated view on vascular dysfunction in AD. Summary: In AD, the cerebral vasculature undergoes pronounced cellular, morphological and structural changes, which alters regulation of blood flow, vascular fluid dynamics and vessel integrity. Stiffening of central blood vessels lead to transmission of excessive pulsatile energy to the brain microvasculature, causing endorgan damage. Moreover, a dysregulated hemostasis and chronic vascular inflammation further impede vascular function, where its mediators interact synergistically. Changes of the cerebral vasculature are triggered and driven by systemic vascular abnormalities that are part of aging, and which can be accelerated and aggravated by cardiovascular diseas-es. Key Messages: In AD, the cerebral vasculature is the locus where multiple pathogenic processes converge and contribute to cognitive impairment. Understanding the molecular mechanism and pathophysiology of vascular dysfunction in AD and use of vascular blood-based and imaging biomarker in clinical studies may hold promise for future prevention and therapy of the disease.

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“…(assessed with the MMSE) with respect to baseline measures (Radaideh et al 2011). The protective effect of antihypertensives in preventing cognitive decline remains a matter of debate; for a recent discussion on this topic the reader is referred to a recent review .…”

Section: Blood Pressure-lowering Drugsmentioning

confidence: 99%

Arterial stiffness, cognitive impairment and dementia: confounding factor or real risk?

Iulita

Colina

Girouard

2017

Journal of Neurochemistry

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Large artery stiffness is a frequent condition that arises with ageing, and is accelerated by the presence of co-morbidities like hypertension, obesity and diabetes. Although epidemiological studies have indicated an association between arterial stiffness, cognitive impairment and dementia, the precise effects of stiff arteries on the brain remains obscure. This is because, in humans, arterial stiffness is often accompanied by other factors such as age, high blood pressure, atherosclerosis and inflammation, which could themselves damage the brain independently of stiffness. Therefore, the question remains: is arterial stiffness a true risk for cognitive decline?Or, is it a confounding factor? In this review, we provide an overview of arterial stiffness and its impact on brain function based on human and animal studies. We summarize the evidence linking arterial stiffness to cognitive dysfunction and dementia, and discuss the role of new animal models to better understand the mechanisms by which arterial stiffness affects the brain. We close with an overview of treatments to correct stiffness and discuss the challenges to translate them to real patient care.

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Eprosartan-Based Hypertension Therapy, Systolic Arterial Blood Pressure and Cognitive Function: Analysis of Middle East Data From the Oscar Study

Cited by 3 publications

References 17 publications

Effects of Antihypertensive Drugs on Cognitive Function in Elderly Patients with Hypertension: A Review

Effects of Antihypertensive Drugs on Cognitive Function in Elderly Patients with Hypertension: A Review

An Integrated View on Vascular Dysfunction in Alzheimer’s Disease

Arterial stiffness, cognitive impairment and dementia: confounding factor or real risk?

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