ePS05.1 Nutritional formula pre-hydrolyzed by novel point of care lipase device (EFIC™) leads to increased fat absorption in young pigs with exocrine pancreatic insufficiency (EPI)

Grujić, Danica; Fedkiv, Olexandr; Никандрова, Е С; Mosiejchuk, N.; Kirko, Siarhei; Osadchenko, I.; Kovalenko, T. M.; Drahanchuk, O.; Parshykov, O.; Гончарова, Е. В.; Freedman, Steven D.; Martin, Camilia R.; Pierzynowski, Stefan

doi:10.1016/s1569-1993(15)30160-0

Cited by 2 publications

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“…A great advantage of using fistulated animals to investigate digestive processes in the case of impaired digestion due to EPI is the possibility of testing the efficacy of different enzyme preparations used for pancreatic enzyme replacement therapy under totally standardized conditions [ 31 , 35 , 55 , 56 , 57 ]. Furthermore, different diets and dietetic measures can be comparatively tested as well [ 58 , 59 , 60 , 61 ].…”

Section: Use Of Ileo-cecal Fistulated Pigs In Research On Diverse mentioning

confidence: 99%

“…Although the limitations of every method should be evaluated critically in research, it needs to be emphasized that the animal model of the pancreatic duct ligated pig has been established justifiedly as the gold standard to study EPI and to test the efficacy of substituted enzymes [ 29 , 50 , 52 , 53 , 54 , 55 , 56 , 57 ]. This model enables the study of the manifold effects of EPI on body composition and quantification and sampling of diverse tissues (when slaughtering the animals after a defined period of EPI) [ 36 , 38 ].…”

Section: Use Of Ileo-cecal Fistulated Pigs In Research On Diverse mentioning

confidence: 99%

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Black‐Box Gastrointestinal Tract—Needs and Prospects of Gaining Insights of Fate of Fat, Protein, and Starch in Case of Exocrine Pancreatic Insufficiency by Using Fistulated Pigs

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Kamphues

2017

Nutrients

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Exocrine pancreatic insufficiency (EPI) results in the maldigestion and malabsorption of nutrients. The digestive processes in humans and other monogastric species like rat and pig are characterized by a predominantly enzymatic digestion within the small intestine and microbial fermentation located in the hindgut. For protein, it is doctrine that only prececally absorbed amino acids can be transferred to the amino acid pool of the host, while postileal absorption of nitrogen-containing compounds occurs mainly in the form of ammonia, being a burden rather than a benefit for the organism. The pig is an established animal model for humans to study digestive processes. As digestion is markedly impaired in case of EPI the use of an appropriate animal model to study the effects of this disease and to optimize treatment and dietetic measures is of special interest. By using an animal model of experimentally-induced EPI allowing differentiating between digestive processes in the small as well as in the large intestine by use of ileo-cecal fistulated animals, marked effects of EPI on prececal digestion of starch and protein could be shown. The data indicate that estimation of digestibility of nutrients over the entire digestive tract results in a distinct overestimation of enzymatic digestion of starch and protein. Therefore, this model clearly shows that protein and starch digestion are significantly reduced in case of EPI although this cannot be detected on a fecal level. As postileal fermentation of starch is associated not only with energy losses but also with intensive gas production, this is of special interest to minimize meteorism and improve wellbeing of patients.

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Section: Use Of Ileo-cecal Fistulated Pigs In Research On Diverse mentioning

confidence: 99%

Section: Use Of Ileo-cecal Fistulated Pigs In Research On Diverse mentioning

confidence: 99%

Black‐Box Gastrointestinal Tract—Needs and Prospects of Gaining Insights of Fate of Fat, Protein, and Starch in Case of Exocrine Pancreatic Insufficiency by Using Fistulated Pigs

Mößeler

Kamphues

2017

Nutrients

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Nutrition, diabète, gastro-entérologie

Abély

2015

Revue des Maladies Respiratoires Actualités

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ePS05.1 Nutritional formula pre-hydrolyzed by novel point of care lipase device (EFIC™) leads to increased fat absorption in young pigs with exocrine pancreatic insufficiency (EPI)

Cited by 2 publications

References 0 publications

Black‐Box Gastrointestinal Tract—Needs and Prospects of Gaining Insights of Fate of Fat, Protein, and Starch in Case of Exocrine Pancreatic Insufficiency by Using Fistulated Pigs

Black‐Box Gastrointestinal Tract—Needs and Prospects of Gaining Insights of Fate of Fat, Protein, and Starch in Case of Exocrine Pancreatic Insufficiency by Using Fistulated Pigs

Nutrition, diabète, gastro-entérologie

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