Epstein-Barr virus and Hodgkin lymphoma in Jordan

Sughayer, Maher A.; Haddad, Hussam; Al-Yousef, Rana M.; El‐Khateeb, Mohammed

doi:10.1016/j.hemonc.2013.12.002

Cited by 16 publications

(25 citation statements)

References 33 publications

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“…The highest incidence of EBV positivity was noted in India and Saudi Arabia (82 and 88%, respectively) [23, 24]. The lowest expression of EBV was noted in Jordan (43.6%) [25]. Our results were comparable with those of another study conducted in Pakistan depicting 50% expression of EBV in Hodgkin lymphoma [26].…”

Section: Discussionsupporting

confidence: 83%

Latent membrane protein 1 (LMP1) expression in Hodgkin lymphoma and its correlation with clinical and histologic parameters

et al. 2017

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BackgroundHodgkin lymphoma is one of the most prevalent lymphoproliferative disorders in Pakistan; however, no risk factors for this disease have yet to be established in our population. Epstein–Barr virus (EBV) is a well-known risk factor for Hodgkin lymphoma in endemic regions of the world; however, frequency of its association in our population has not been widely studied. Latent membrane protein 1 (LMP1) expression by immunohistochemistry (IHC) is a surrogate marker of EBV in Hodgkin lymphoma. Therefore, we aimed to evaluate the frequency of expression of LMP1 in cases of Hodgkin lymphoma at our institute and its correlation with other clinical and histologic parameters.MethodsThe study included 66 cases of Hodgkin lymphoma diagnosed at Liaquat National Hospital over a duration of 2 years from January 2014 to December 2015. The slides and blocks of all cases were retrieved, and representative blocks were selected for LMP1 by IHC. LMP1 expression of >10% of cells was considered as positive expression and correlated with histologic subtypes and clinical parameters like age, gender, and site of involvement.ResultsThe mean age of patients was 35.11 (+20.22). LMP1 expression was found in 68.1% (45/66) of cases of Hodgkin lymphoma. Mean age of the patients with LMP1 expression was 32.04 (+21.02). LMP1 expression was found in 40% cases of lymphocyte-rich, 66.7% of lymphocyte-depleted, 73.9% of mixed cellularity, 66.7% of nodular sclerosis, and 73.7% of classic Hodgkin lymphoma, NOS. No significant correlation of LMP1 expression with any clinical or histological parameter could be established in our studied patient population.ConclusionsA high frequency of expression of LMP1 is seen in cases of Hodgkin lymphoma at our setup comparable to endemic regions of the world; therefore, preventive and treatment protocols should be designed accordingly.

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Section: Discussionsupporting

confidence: 83%

Latent membrane protein 1 (LMP1) expression in Hodgkin lymphoma and its correlation with clinical and histologic parameters

et al. 2017

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“…A recent report has shown that, in the Republic of Korea, a shift from pattern II to pattern III has occurred over a period of 31 years, reflecting the impact of social and economic development in this country 4 . Similar studies in other countries, however, have identified a mixed pattern (Pattern II with a bias to Pattern I or Pattern III, depending on the influence of more pronounced poorer or improved socioeconomic conditions) 5 – 12 .…”

Section: Introductionsupporting

confidence: 71%

Frequency of EBV associated classical Hodgkin lymphoma decreases over a 54-year period in a Brazilian population

Campos

Moreira

Ribeiro

et al. 2018

Sci Rep

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The epidemiology of classical Hodgkin lymphoma varies significantly in populations with different socioeconomic conditions. Among other changes, improvement in such conditions leads to a reduction in the association with EBV infection and predominance of the nodular sclerosis subtype. This study provides an overview of the epidemiology of 817 cases of classical Hodgkin lymphoma diagnosed in five reference hospitals of the State of Sao Paulo, Brazil, over 54 years (1954–2008). The cases were distributed in 3 periods (1954–1979; 1980–1999; and 2000–2008). EBV-positive cases decreased from 87% to 46%. In children and adolescents (<15 years) and in young adults (15–45 years), EBV-positive cases decreased respectively from 96% to 64%, and from 85% to 32%. The percentage of male patients declined from 80% to 58%. In older patients (>45 years), the decrease in EBV infection was not significant. Nodular Sclerosis was the most common subtype in all periods. These results support the hypothesis that, in the Brazilian State of Sao Paulo, classical Hodgkin lymphoma has changed and now shows characteristics consistent with Pattern III observed in populations that experienced a similar socioeconomic transition.

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“…This result is in the range of reported positivity in European countries [13,18,21,26]. EBV positivity varies depending on geographic area and ethnicity: 17% in the Czech Republic, 79% in Kenya, 78% in India, 52% in Zambia, and 46% in Jordan [10,11,17,18,21,27]. The EBV rate in cHL has been evolving over time.…”

Section: Discussionmentioning

confidence: 57%

“…The presence of EBV in cHL varies from 13 to 79% depending on the series. It is associated with younger or older age (<10 or > 50 years ), lower economic status, ethnicity (Hispanic, African population) [8,9], MC histology, and immunosuppression [10][11][12][13][14][15][16][17][18][19][20][21][22][23]. The presence of in situ EBV has been shown to have no prognostic impact except for patients > 50 years of age [24].…”

Section: Introductionmentioning

confidence: 99%

Epstein Barr Virus in childhood and adolescent classical Hodgkin lymphoma in a French cohort of 301 patients

Pereira

Boudjemaa

Besson

et al. 2021

Preprint

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To analyze the role of Epstein-Barr virus (EBV) in the biological and clinical characteristics of patients treated for classic Hodgkin lymphoma (cHL) in France. Bio-pathological data of 301 patients treated for a cHL in or according to the protocol of the EuroNet PHL-C1 trial between November 2008 and February 2013 were centrally reviewed. Median age at diagnosis was 14 [3-18] years and the F/M ratio 0.86, 0.47 before 10 years and 0.9 from 11 to 18. CHL subtypes were nodular sclerosis for 266/301 (88%) patients, mixed cellularity for 22/301 (7%), lymphocyte rich for 2/301 (1%), and 11/301 were unclassified. EBV expression in situ (EBV cHL) was observed for 68/301 (23%) patients, significantly associated with MC subtype and male gender, and there was a trend with age <10 years, it was particularly overrepresented in boys below 10 years: 15/23 (65%) vs 28/139 among other male patients (20%). Event-free and overall survival were equivalent between EBV and non-EBV cHL patients. EBV viral load was tested for 108/301 patients and detectable in 22/108 (22%) cases. A positive viral load was overrepresented in EBV cHL versus non-EBV cHL patients: 13/28 (46%) vs 9/80 (11%). Detailed semi-quantitative histological analysis showed a high number of B-cell residual follicles in EBV cHL and no significant association with CD 20 or PAX 5 immunostaining in tumoral cells relative to EBV-negative HL. Distribution of EBV cHL in children and adolescents is associated with young age and male gender, suggesting a specific physiopathology and may require a differential therapeutic approach.

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Epstein-Barr virus and Hodgkin lymphoma in Jordan

Abstract: The epidemiology of HL in Jordan and some developing countries is approaching that of developed countries.

Cited by 16 publications

References 33 publications

Latent membrane protein 1 (LMP1) expression in Hodgkin lymphoma and its correlation with clinical and histologic parameters

Latent membrane protein 1 (LMP1) expression in Hodgkin lymphoma and its correlation with clinical and histologic parameters

Frequency of EBV associated classical Hodgkin lymphoma decreases over a 54-year period in a Brazilian population

Epstein Barr Virus in childhood and adolescent classical Hodgkin lymphoma in a French cohort of 301 patients

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