Epstein-Barr-Virus Antibodies in American and African Burkitt's Lymphoma

Surface marker characteristics and Epstein-Barr virus studies of two established North American Burkitt's lymphoma cell lines.

“…Until recently, all African Burkitt's lymphoma biopsies studied had been shown to contain EBV genomes by EBNA staining (31) and/or nucleic acid hybridization (33,34 (12,13). The similarity of these nonendemic cases to those of African origin gained credibility when it was found that some patients had elevated serum antibody titers to EBV (8,9) and that tumor cells from an AmBL patient had B cell characteristics (6). However, with the introduction of more stringent techniques for the detection of EBV-specific DNA (33) or nuclear antigens (24), studies of AmBL biopsies have consistently revealed the absence of demonstrable EBV genomes (10,11).…”

Burkitt's lymphoma in Japan: Clinicopathological features of twenty-two patients.

“…In contrast, the titers of antibodies to EB virus in Japanese patients were comparable to those found in control group. In American patients, Levine et al (1972) reported that there were significantly higher titers of anti-EB virus antibody in American patients as compared with controls, while Hirshaut et al (1973) described that titers in American cases did not differ significantly from those found in control groups. Arseneau et al (1975) reported that serum LDH levels were significantly lower in patients with stage I-II than those with stage III-IV, suggesting a good correlation between LDH levels and stage of the disease.…”

“…African patients with Burkitt's lymphoma generally have markedly elevated titers of the anti-EB virus antibody (Henle et al 1969;Hirshaut et al 1973). In contrast, the titers of antibodies to EB virus in Japanese patients were comparable to those found in control group.…”

Epidemiology of Epstein—Barr Virus and Associated Diseases in Man

“…Hirshaut et al (1973), studying 15 cases of American BL-type lymphomas, failed to find any significant serological differences between cases and age/sex-matched controls. By molecular hybridization techniques, absence of viral DNA in a series of American Burkitt-type lym-phomas was reported by Pagano et al (1973).…”