Epstein-Barr Virus-Associated Cholangiocarcinoma with Lymphoepithelioma-Like Component

Ortiz, Rosa; Garijo, Gloria; Adrados, Manuel; Lopez-Bonet, Eugenio; Acero, Doroteo; Bernadó, Luis

doi:10.1177/106689690000800418

Cited by 38 publications

(43 citation statements)

References 27 publications

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“…Although there is no predilection for either sex (male: female 7:7), cases of Asian race predominated (11 of 14 patients were Asian). Except for a 19-year-old Hispanic girl reported by Ortiz et al [15] , all patients were adults (average 55.1 years; range 19-71). The 13 cases of biliary LEC reported previously were all intrahepatic cholangiocarcinoma, and this is the first case report of extrahepatic biliary lymphoepithelioma-like cholangiocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Since Hsu et al [12] reported a case of intrahepatic lymphoepithelioma-like cholangiocarcinoma in 1996, only 12 additional cases of LEC of the biliary tract have been reported in the English literature [13][14][15][16][17][18][19][20] . In Table 1, we summarize the clinicopathological features of these 13 cases and the present case of biliary LEC.…”

Section: Discussionmentioning

confidence: 99%

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Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct

Ishida

Mori²,

Shiomi³

et al. 2011

WJGO

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A carcinoma displaying undifferentiated features with dense lymphoplasmacytic infiltration is defined as a lymphoepithelioma-like carcinoma (LEC), and some of LEC is associated with Epstein-Barr virus (EBV). All of the 13 previously reported cases of LEC of the biliary system were intrahepatic in location. Herein, we describe the first case of LEC of the inferior common bile duct. A 68-year-old Japanese man, who had been previously treated for hepatocellular carcinoma using microwave coagulation therapy, was found to have tumors of the common bile duct and pancreas head. Histopathological study of the resected tumor showed solid or cohesive nests of large undifferentiated cells with irregular large vesicular nuclei and nucleoli. Around the tumor cell nests, dense lymphoplasmacytic infiltration was observed. Focal glandular differentiation (approximately 5%) was also present. These histopathological features corresponded morphologically to LEC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, CK 19 and CA19-9, but negative for CK 20 and Hep Par 1. In situ hybridization for Epstein Barr virus early small RNAs disclosed no nuclear signal in tumor cells. Therefore, a diagnosis of non-EBV-associated LEC of the inferior common bile duct was made. Although the prognosis of the biliary LEC is thought to be better than that of conventional cholangiocarcinoma, the differences in prognosis between EBV-positive and -negative cases have not yet been established. Therefore, additional case studies will be needed to clarify the clinicopathological features of LEC of the biliary tract.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct

Ishida

Mori²,

Shiomi³

et al. 2011

WJGO

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“…Lymphoepithelioma‐like cholangiocarcinoma (LELCC) is a rare variant of intrahepatic cholangiocarcinoma (IHCC). Only 16 cases have been reported in the literature, and about 62.5% of these cases were associated with EBV …”

Section: Introductionmentioning

confidence: 99%

Epstein–Barr virus‐associated lymphoepithelioma‐like cholangiocarcinoma: a rare variant of intrahepatic cholangiocarcinoma with favourable outcome

et al. 2014

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“…However, p53 nuclear staining is frequently positive in LELC of other organs [32,38,50] and in more than 50% of nasopharyngeal carcinomas in most series [18,19,31,40]. In this anatomical location, it is frequently associated with EBV [18,31,41], with a strong association between p53 overexpression and EBER status [18].…”

Section: Discussionmentioning

confidence: 96%

Lymphoepithelioma-like carcinoma of the bladder: three cases with clinicopathological and p53 protein expression study

et al. 2004

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Lymphoepithelioma-like carcinoma of the bladder is an uncommon neoplasm, of which 49 cases have been described in the English literature, none of which has been studied for p53 protein expression. We studied three muscle-infiltrating cases of this tumor using immunohistochemical, in situ hybridization and polymerase chain reaction (PCR) methods. The three cases were positive for epithelial markers and negative for lymphoid antigens in the tumoral syncytial areas. The intensive infiltrate of small cells was negative for epithelial and positive for lymphoid markers. This population was mainly made up of cytotoxic T-lymphocytes, positive for TIA-1. p53 protein was intensely positive in more than 90% of the epithelial component nuclei, being negative in the lymphoid cells. PCR study did not show mutations on p53. Both lymphocytes and epithelium were negative for Epstein-Barr virus markers, such as the latent membrane protein and EBER (Epstein-Barr-encoded RNA). The prognosis was very good after radiotherapy and chemotherapy treatment, preserving the bladder despite the muscle infiltration. The presence of an intense cytotoxic T-lymphocyte population may be related to this good prognosis. Both aspects, p53 protein status and T-lymphoid population, had never been studied before in bladder lymphoepithelioma-like carcinoma.

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Epstein-Barr Virus-Associated Cholangiocarcinoma with Lymphoepithelioma-Like Component

Cited by 38 publications

References 27 publications

Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct

Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct

Epstein–Barr virus‐associated lymphoepithelioma‐like cholangiocarcinoma: a rare variant of intrahepatic cholangiocarcinoma with favourable outcome

Lymphoepithelioma-like carcinoma of the bladder: three cases with clinicopathological and p53 protein expression study

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