Epstein–Barr virus‐associated <scp>T</scp>/natural killer‐cell lymphomas in the elderly: The first consensus meeting in Kofu 2013

Hamada, Takeshi; Nakamura, Shigeo; Ko, Young Hyeh; Yoshino, Tadashi; Ohshima, Koichi; Matsuzawa, Takamitsu; Miura, Keiko; Takahashi, Tamiko; Nomura, Hisashi; Hoshino, Tsuneo; Suzuki, Daisuke; Shimada, Shinji; Iwatsuki, Keiji

doi:10.1111/1346-8138.12373

Cited by 9 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, NKTL affecting middle-aged or elderly patients may feature de novo symptoms with clonal and rapid expansion of neoplastic EBV + T/NK cells. 5 Patients with nodal EBV + CTL present with lymphadenopathy without nasopharyngeal involvement. However, this nodal lymphoma and NKTL share some biological properties, including CM expression and EBV positivity.…”

mentioning

confidence: 99%

Nodal EBV+ cytotoxic T-cell lymphoma: A literature review based on the 2017 WHO classification

Kato

Yamashita

Nakamura

2020

JCEH

Self Cite

View full text Add to dashboard Cite

Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) accounts for the largest proportion of mature T-cell and natural killer (NK)-cell neoplasms in the 2017 World Health Organization (WHO) classification. 1 We have found evidence that nodal cytotoxic molecule (CM)-positive PTCL-NOS [(also called cytotoxic T-cell lymphoma (CTL)] constitutes a unique category. This group encompasses a wide spectrum of presentations, ranging from indolent disease in a minority to an aggressive neoplasm in the majority; in 45-51% of CTL cases, the pathogenesis is closely associated with Epstein-Barr virus (EBV). 2,3 These biological properties are in clear contrast to those of nodal CM-negative T-cell neoplasms, which predominantly comprise PTCL-NOS, angioimmunoblastic T-cell lymphoma, and adult T-cell leukemia (ATLL, positive for human T-cell leukemia virus type 1)-although a small subset of patients (2%) may exhibit EBV-positive bystander lymphocytes. 2 This suggests that EBV is detected as the result of immunological deterioration in the tumor microenvironment, but that it plays little role in the pathogenesis of the latter neoplasm.Among mature T/NK-cell tumors, the detection of EBV on tumor cells is essential for the diagnosis of nasal type NK/ T-cell lymphoma (NKTL), aggressive NK-cell leukemia, or EBV + T/NK-cell lymphoproliferative diseases of childhood-all of which exhibit CM expression and frequent extranodal involvement. 4 In most NKTL cases, the prototypic disease initially presents in the upper aerodigestive tract. This disease can also involve a wide variety of extranodal sites, including the skin and gastrointestinal tract, and may exhibit secondary lymph node lesions. Indeed, NKTL affecting middle-aged or elderly patients may feature de novo symptoms with clonal and rapid expansion of neoplastic EBV + T/NK cells. 5 Patients with nodal EBV + CTL present with lymphadenopathy without nasopharyngeal involvement. However, this nodal lymphoma and NKTL share some biological properties, including CM expression and EBV positivity. We first elucidated the clinicopathological characteristics of nodal EBV + CTL, which is characterized by diffuse monomorphic infiltration of large cells that often have a centroblastoid

show abstract

mentioning

confidence: 99%

Nodal EBV+ cytotoxic T-cell lymphoma: A literature review based on the 2017 WHO classification

Kato

Yamashita

Nakamura

2020

JCEH

Self Cite

View full text Add to dashboard Cite

show abstract

“…Incluso existen reportes de PLC en pediatría secundaria a la aplicación de la vacuna antitripleviral MMR (del inglés-measles, mumps, and rubella-), anti-influenza y antihepatitis B. Es de importancia tener en cuenta la posible sobreinfección secundaria con Staphylococcus epidermidis y Pseudomona aeruginosa. [49][50][51][52][53][54] Incluso, hay que tener en cuenta que hay casos clínicos totalmente atípicos, tal como se reporta en un trabajo, en el diagnóstico semiológico era de acrodermatititis enteropática, pero la biopsia mostraba una clara vasculitis. 55 Existen diferencias en la historia natural de la enfermedad en niños y adultos, ya que en los primeros hay más probabilidades de desarrollar un curso ininterrumpido con mayor distribución de las lesiones, más despigmentación y poca respuesta al tratamiento convencional.…”

Section: Pitiriasis Liquenoide Linfomatoide (Pll)unclassified

Manifestaciones atípicas del síndrome de vasculitis-angeítis- endotelitis (SVAE) cutánea

Baquero¹,

Tróchez²,

Campo³

et al. 2019

Repert. Med. Cir.

View full text Add to dashboard Cite

Se reportan dos pacientes con diagnóstico histopatológico de vasculitis cutánea de presentación clínica atípica. Un joven de 13 años con lesiones bullosas y flictenulares generalizadas de 2-3 cm sin sobreinfección, que se iniciaron en la cavidad oral y se extendieron al tórax anterior y extremidades, asociadas con infección ventilo-respiratoria tipo neumonía adquirida en la comunidad (NAC), que requirió antibióticos y corticoides sistémicos, con resolución completa a los 17 días y diagnóstico definitivo de vasculitis por hipersensibilidad. El otro paciente corresponde a un adulto de 58 años con historia de 18 meses de lesiones maculares purpúricas en miembros superiores e inferiores, algunas confluyen generando placas violáceas no mayores de 5 cm. Cursó con diabetes, retinopatía e hipertensión arterial. La biopsia mostró vasculitis leucocitoclásica con “signo de promontorio”, por lo cual se sospechó sarcoma de Kaposi que se descartó. El diagnóstico definitivo fue vasculitis linfocítica en pitiriasis liquenoide crónica (PLC).

show abstract

“… 2 Epstein-Barr virus (EBV) is expressed in almost all cases of ENKTL, implying that it may play a pathogenic role. 3 Extra-nasal ENKTL was first described in 1992 by Chan et al and this entity demonstrates many morphologic and immunophenotypic similarities to nasal ENKTL, thus the common designation “nasal-type” even for the extra-nasal forms.…”

Section: Introductionmentioning

confidence: 99%

Multifocal primary cutaneous extranodal NK/T lymphoma nasal type

Vasconcelos

Ferreira

Soares‐Almeida

et al. 2016

An. Bras. Dermatol.

View full text Add to dashboard Cite

Nasal type extranodal NK/T-cell lymphoma is a distinct entity according to the World Health Organization classification. Although 60% to 90% of patients with this disease present with a destructive mass in the midline facial tissues, it may also primarily or secondarily involve extranasal sites, like the skin. We report the case of a 77-year-old patient that came to our department with erythematous plaques of the right leg and eczematous lesions of the trunk. These lesions were biopsied and the patient was diagnosed with extranodal NK/T-cell lymphoma, nasal type. He was treated with multi-agent systemic chemotherapy but died 5 months after diagnosis. This case highlights the rarity and variability of cutaneous features of this disease and its aggressive course and poor prognosis.

show abstract

Epstein–Barr virus‐associated T/natural killer‐cell lymphomas in the elderly: The first consensus meeting in Kofu 2013

Cited by 9 publications

References 8 publications

Nodal EBV+ cytotoxic T-cell lymphoma: A literature review based on the 2017 WHO classification

Nodal EBV+ cytotoxic T-cell lymphoma: A literature review based on the 2017 WHO classification

Manifestaciones atípicas del síndrome de vasculitis-angeítis- endotelitis (SVAE) cutánea

Multifocal primary cutaneous extranodal NK/T lymphoma nasal type

Contact Info

Product

Resources

About