Epstein-Barr Virus-associated Smooth Muscle Tumors in AIDS Patients: A Largest Case (Series)

Issarachaikul, Ratima; Shuangshoti, Shanop; Suankratay, Chusana

doi:10.2169/internalmedicine.53.2674

Cited by 21 publications

(25 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EBVSMT occurs mainly in immunocompromised patients, either in the setting of solid organ transplantation or with HIV/AIDS . Typically, the disease has an indolent course, is locally invasive, and is rarely the cause of death .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A 33‐Year‐Old HIV‐Positive Male with Spinal Mass

2016

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…Rare cases involved the basal ganglia and pontine cistern . EBVSMT appears to arise when patients exhibit severe immunosuppression due to their underlying HIV infection .…”

Section: Discussionmentioning

confidence: 99%

A 33‐Year‐Old HIV‐Positive Male with Spinal Mass

2016

View full text Add to dashboard Cite

“…HIV-SMTs are most likely to invade the central nervous system (CNS), followed by the liver, lungs, and other locations. [ 1 ] Many laboratory techniques, including serological techniques, polymerase chain reaction (PCR) and immunohistochemistry (IHC), are employed to determine the aetiologies of these tumours. IHC confirmed positive staining for alpha-smooth muscle actin (SMA), and nuclear staining for EBV-encoded RNA-1 (EBER-1).…”

Section: Introductionmentioning

confidence: 99%

Epstein-Barr virus associated hepatic smooth muscle tumor in a patient with acquired immunodeficiency syndrome

Zhou

Guo

et al. 2020

Medicine

View full text Add to dashboard Cite

Introduction: Epstein-Barr virus (EBV) associated smooth muscle tumors (SMTs) usually present under the condition of immunosuppression, including congenital immunodeficiency syndrome-SMT, post-transplantation-SMT and HIV-SMT. HIV-SMTs are most likely to invade the central nervous system, followed by the liver, lungs, and other locations. [ 1 ] Many laboratory techniques, including serological techniques, polymerase chain reaction and immunohistochemistry (IHC), are employed to determine the aetiologies of these tumours. With respect to therapy, surgical resection is the main treatment. In patients with immunodeficiency, improving immune status is significant for defending against other viruses. We describe a case of the primary focus of SMT in the liver of HIV-positive patient without any metastasis. Patient concerns: A young male HIV-positive patient complained of fever and abdominal pain for 2 months. Diagnosis: IHC of liver tissue confirmed the finding: EBV-related smooth muscle tumor. Interventions: Given the patient's general condition, he was not a suitable candidate for surgical resection. He was given antibiotics, antifungal agents and EBV-directed agents to control infection as well as highly active antiretroviral therapy to enhance the immunity. Outcomes: The patient's symptoms improved. He was discharged. Conclusions: In conclusion, EBV-related HIV-SMTs is a rare neoplasm found in the liver among immunodeficient patients. This case highlights that a variety of examinations such as IHC for smooth muscle markers (smooth muscle actin and desmin) and EBER, as well as polymerase chain reaction for EBV DNA should be done when diagnoses are ambiguous.

show abstract

“…These tumors are typically positive for the Epstein–Barr virus (EBV) and can manifest themselves at any time and in any organ after transplantation [ 1 ]. Similar neoplasms can also occur in any other immunosuppressive condition, in particular after infection with human immunodeficiency virus (HIV; HIV-SMT) or congenital immune defects (CI-SMT) [ 1 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Non-canonical WNT6/WNT10A signal factor expression in EBV+ post-transplant smooth muscle tumors

et al. 2018

View full text Add to dashboard Cite

Post-transplant smooth muscle tumors (PTSMTs) are rare mesenchymal neoplasms which occur after solid organ or haematopoietic stem cell transplantation. PTSMT typically consist of Epstein–Barr-virus (EBV)+ smooth muscle-like cells and show an intermediate malignancy. Their main occurrences are visceral organs, especially the liver, but intracranial appearances are described and associated with a poor prognosis. EBV drives the growth of PTSMT; however, the underlying molecular mechanisms still remain unclear. Gene expression analysis of a set of morphologically similar tumors (leiomyomas, leiomyosarcomas, angioleiomyomas and endothelial haemangiomas) from patients without immunosuppression or EBV-association was performed. Our findings indicate that PTSMT’s growth is driven by two factors of the wingless-type protein family: WNT6 and WNT10A. We are first to report that in PTSMTs, a non-canonical activation of WNT, independent of beta-catenin, drives tumor cell proliferation via MTOR/AKT1, MYC and Cyclin D2.Electronic supplementary materialThe online version of this article (10.1186/s13569-018-0096-8) contains supplementary material, which is available to authorized users.

show abstract

Epstein-Barr Virus-associated Smooth Muscle Tumors in AIDS Patients: A Largest Case (Series)

Cited by 21 publications

References 21 publications

A 33‐Year‐Old HIV‐Positive Male with Spinal Mass

A 33‐Year‐Old HIV‐Positive Male with Spinal Mass

Epstein-Barr virus associated hepatic smooth muscle tumor in a patient with acquired immunodeficiency syndrome

Non-canonical WNT6/WNT10A signal factor expression in EBV+ post-transplant smooth muscle tumors

Contact Info

Product

Resources

About