Epstein-Barr virus-associated smooth muscle tumour presenting as a parasagittal brain tumour

Ibebuike, Kaunda; Pather, Sugeshnee; Emereole, O.; Ndolo, P.; Kajee, Afsana; Gopal, Rasik; Naidoo, Sanushka

doi:10.1016/j.jocn.2011.09.037

Cited by 11 publications

(5 citation statements)

References 11 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EBV‐SMTs have been documented to invade a wide variety of organs and systems, such as lung, liver, genitourinary organs, and central nervous system (CNS) 22–24 . Concurrent or consecutive multiple involvements have also been reported 25–28 .…”

Section: Introductionmentioning

confidence: 99%

“…18,20,21 EBV-SMTs have been documented to invade a wide variety of organs and systems, such as lung, liver, genitourinary organs, and central nervous system (CNS). [22][23][24] Concurrent or consecutive multiple involvements have also been reported. [25][26][27][28] Despite various reports being published, 21,[29][30][31] currently, there were no epidemiological, demographical, and survival data regarding patients with EBV-SMT invading CNS in the literature.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Role of surgery in treating epstein‐barr virus‐associated smooth muscle tumor (EBV‐SMT) with central nervous system invasion: A systemic review from 1997 to 2019

et al. 2021

View full text Add to dashboard Cite

Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) is a rare subset of spindle cell tumor. The presence of EBV DNA in smooth muscle tumor was first documented in 1994, and the term EBV-SMT was first described in 1995. 1-4 In the past few decades, patients at any age who were diagnosed with EBV-SMT, have been proved to have a strong correlation with immunodeficiency. 5-8 Cases of EBV-SMTs are most commonly correlated to secondary (or acquired) immunodeficiency, and the cases mainly consisted of patients with human immunodeficiency virus (HIV) infection 5,9-12 or with post-organ transplantation (POT) under immunosuppressants, 10,11,13 while a small

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Role of surgery in treating epstein‐barr virus‐associated smooth muscle tumor (EBV‐SMT) with central nervous system invasion: A systemic review from 1997 to 2019

et al. 2021

View full text Add to dashboard Cite

show abstract

“…16 Although there have been cases of PILMS reported in immunocompetent patients, [20][21][22][23] EBV-associated PILMSs have only been reported in immunocompromised patients, with the exception of this case (Table 1). [9][10][11][12]14 Given that PILMSs are very rare and frequently originate from the dura, they tend to be misdiagnosed as meningiomas. 23 Further, on frozen section, intraoperative tumor samples are difficult to distinguish from meningiomas; therefore, immunostaining is often necessary to confirm the diagnosis of LMS.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 Previous cases of primary intracranial EBV smooth muscle tumors have been described in immunocompromised patients with human immunodeficiency virus (HIV) or following organ/stem cell transplantation. [9][10][11][12][13] Only 1 case has been reported in a seemingly immunocompetent patient diagnosed with Hodgkin lymphoma. 14 To the best of our knowledge, no cases of PILMS have been reported in immunocompetent patients.…”

mentioning

confidence: 99%

Epstein-Barr virus–associated primary intracranial leiomyosarcoma in an immunocompetent patient: illustrative case

Tabor

Lei

Morales-Valero

et al. 2023

Journal of Neurosurgery: Case Lessons

View full text Add to dashboard Cite

BACKGROUND Primary intracranial leiomyosarcomas (PILMSs) are extremely rare tumors arising from smooth muscle connective tissue. PILMSs have been shown to be associated with Epstein-Barr virus (EBV). Thus far, EBV-associated PILMS has been exclusively described in immunocompromised patients. OBSERVATIONS A 40-year-old male presented with a 2-year history of left-sided headaches, nausea, and vomiting. Magnetic resonance imaging demonstrated a large, heterogeneously enhancing, lobulated, dura-based mass arising from the left middle cranial fossa with associated edema and mass effect. The patient underwent an uncomplicated resection of suspected meningioma; neuropathology revealed the exceedingly rare diagnosis of EBV-associated PILMS. Follow-up testing for human immunodeficiency virus (HIV) and other immunodeficiencies confirmed the patient’s immunocompetent status. LESSONS Primary intracranial smooth muscle tumors are often misdiagnosed as meningiomas due to their similar appearance on imaging. PILMSs have a poor prognosis and gross total resection is the mainstay of treatment in the absence of clear recommendations for management. Prompt diagnosis and resection are important; therefore, these tumors should be included in the differential of dura-based tumors, especially among immunocompromised patients. Although EBV-associated PILMSs usually occur in immunocompromised individuals, their presence cannot be ruled out in immunocompetent patients.

show abstract

“…4,6 It is noteworthy that increased expression of CD21 has not been consistently documented in EBV-SMT occurring in transplant recipients. 7 Despite the rampant epidemic of HIV infection in Africa, EBV-SMT in South Africa is infrequently reported, [8][9][10][11] and the paucity of EBV-SMT data from Africa was noted in a review of published cases by Purgina et al 5 This article serves to contribute clinicopathological experience about HIV-related EBV-SMT in paediatric and adults patients at the largest hospital in Africa.…”

Section: Introductionmentioning

confidence: 97%

Human immunodeficiency virus-related Epstein-Barr virus-associated smooth muscle tumours: South African experience from Chris Hani Baragwanath Academic Hospital

Pather

Wainwright

Sahid

et al. 2017

Southern African Journal of Infectious Diseases

View full text Add to dashboard Cite

Background: Despite the rampant human immunodeficiency (HIV) epidemic in Africa, there is a paucity of published data of HIV-related Epstein-Barr virus-associated smooth muscle tumours (EBV-SMT) from Africa.Methods: We embarked on retrospective documentation of the clinicopathological features of confirmed HIV-related EBV-SMT over a 5-year time frame at the largest hospital in Africa. All haematoxylin and eosin stained tissue sections, immunohistochemistry and EBV in situ hybridisation (ISH) investigations were reviewed in conjunction with clinical data.Results: Fourteen (n = 14) EBV-SMT were confirmed in 13 patients (age range: 10–53 years). Five paediatric patients and a predominance of females (70%) were evident in this series. All patients were HIV seropositive and CD4 counts ranged from 1 to 1331 cells/ul (median 355 cells/ul; mean 442 cells/ul). Tumour-associated pain was a common symptom in the paediatric age group, while neurological symptoms were frequent in the adults due to paraspinal cervicothoracic involvement. Unusual topography, multifocality (n = 5) and smooth muscle morphology in association with round cell features (n = 3) were evident. Immunoexpression of desmin (n = 12), SMA (n = 12) and h-Caldesmon (n = 8) were consistent findings and positive EBV ISH nuclear signaling was demonstrated within all of these tumours. Treatment included antiretroviral therapy, surgical resection, radiation and/or palliative therapy.Conclusion: HIV-associated EBV-SMT are rare tumours that may develop in paediatric or adult patients. A female predominance and multifocal topographic involvement may be evident. AIDS-related co-morbidities are likely to contribute to mortality; and, when these tumours occur in paraspinal regions, debilitating neurological morbidity may manifest.

show abstract

Epstein-Barr virus-associated smooth muscle tumour presenting as a parasagittal brain tumour

Cited by 11 publications

References 11 publications

Role of surgery in treating epstein‐barr virus‐associated smooth muscle tumor (EBV‐SMT) with central nervous system invasion: A systemic review from 1997 to 2019

Role of surgery in treating epstein‐barr virus‐associated smooth muscle tumor (EBV‐SMT) with central nervous system invasion: A systemic review from 1997 to 2019

Epstein-Barr virus–associated primary intracranial leiomyosarcoma in an immunocompetent patient: illustrative case

Human immunodeficiency virus-related Epstein-Barr virus-associated smooth muscle tumours: South African experience from Chris Hani Baragwanath Academic Hospital

Contact Info

Product

Resources

About