Lacrimal gland inflammation, known as dacryoadenitis, is an uncommon condition with various etiologies, ranging from infectious to autoimmune diseases. The clinical course can be acute, subacute, or chronic, with involvement on one or both sides. In the course of mononucleosis, a self-limited eyelid edema is often observed, while dacryoadenitis has been rarely reported. We present the case of an 8-year-old girl with bilateral subacute Epstein–Barr virus-induced dacryoadenitis, who underwent orbital magnetic resonance imaging and gland biopsy, and we performed a comprehensive literature review.