Epstein-Barr virus in breast carcinoma and in triple negative cases impact on clinical outcomes

Mekrazi, Saoussen; Kallel, Imen; Jamai, Dhouha; Yengui, Mariem; Khabir, Abdelmajid; Gdoura, Radhouane

doi:10.1016/j.prp.2023.154484

Cited by 4 publications

(3 citation statements)

References 54 publications

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“…EBV presence is detected in approximately 30-50% of cancer cases globally. Studies from Turkey and Syria have reported EBV positivity rates of 58% and 52%, respectively, in BC cases, while reports from Qatar, Tunisia, Lebanon, and Egypt revealed EBV presence in 49%, 44%, 40%, and 37.5% of BC samples, respectively [23,30,31,[53][54][55]. Additionally, EBV presence in BC tissue has been reported in Iran and Iraq in 27%, and 22.5%, respectively [56,57].…”

Section: Discussionmentioning

confidence: 99%

“…HPV detection and genotyping were conducted using the REALQUALITY RQ-Multi HPV detection kit (AB ANALITICA, Padua, Italy), as previously described [17]. This kit enables the identification of 28 HPV genotypes, including 14 high-risk (16,18,31,33,35,39,45,51,52,56,58,59, 66, 68), 6 potential high-risk (26,53,67,70,73,82), and 8 low-risk (6,11,40,42,43,44,55,83) types. It amplifies a short sequence within the E6 and E7 genes of the HPV genome, individually detecting HPV 16 and HPV 18 genotypes, while other genotypes are detected as pools.…”

Section: Hpv Detection In Breast Cancer Samplesmentioning

confidence: 99%

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Association of Human Papilloma Virus, Cytomegalovirus, and Epstein–Barr Virus with Breast Cancer in Jordanian Women

Khasawneh,

Himsawi,

Sammour

et al. 2024

Medicina

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Background and Objectives: The investigation of oncogenic viruses and their potential association with breast cancer (BC) remains an intriguing area of study. The current work aims to assess evidence of three specific viruses, human papillomavirus (HPV), cytomegalovirus (CMV), and Epstein–Barr virus (EBV) in BC samples and to explore their relationship with relevant clinicopathological variables. Materials and Methods: The analysis involved BC samples from 110 Jordanian female patients diagnosed with BC and breast tissue samples from 30 control patients with no evidence of breast malignancy, investigated using real-time PCR. The findings were then correlated with various clinico-pathological characteristics of BC. Results: HPV was detected in 27 (24.5%), CMV in 15 (13.6%), and EBV in 18 (16.4%) BC patients. None of the control samples was positive for HPV or CMV while EBV was detected in only one (3.3%) sample. While (HPV/EBV), (HPV/CMV), and (EBV/CMV) co-infections were reported in 1.8%, 2.7%, and 5.5%, respectively, coinfection with the three viruses (HPV/CMV/EBV) was not reported in our cohort. A statistically significant association was observed between HPV status and age (p = 0.047), and between clinical stage and CMV infection (p = 0.015). Conclusions: Our findings indicate the presence or co-presence of HPV, CMV, and EBV in the BC subpopulation, suggesting a potential role in its development and/or progression. Further investigation is required to elucidate the underlying mechanisms that account for the exact role of oncoviruses in breast carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Section: Hpv Detection In Breast Cancer Samplesmentioning

confidence: 99%

Association of Human Papilloma Virus, Cytomegalovirus, and Epstein–Barr Virus with Breast Cancer in Jordanian Women

Khasawneh,

Himsawi,

Sammour

et al. 2024

Medicina

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“…Both Glaser et al [ 152 ] and Hachana et al [ 146 ] reported TILs as the only positive EBV localization and EBER-ISH source, respectively. Mekrazi et al [ 129 ] also reported positivity in TILs rather than tumor cells when analyzing PCR-positive specimens with ISH.…”

Section: Ebvmentioning

confidence: 99%

The Role of Oncogenic Viruses in the Pathogenesis of Sporadic Breast Cancer: A Comprehensive Review of the Current Literature

Rossi,

Inzani,

Cesari

et al. 2024

Pathogens

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Breast cancer is the most common malignancy in the female sex; although recent therapies have significantly changed the natural history of this cancer, it remains a significant challenge. In the past decade, evidence has been put forward that some oncogenic viruses may play a role in the development of sporadic breast cancer; however, data are scattered and mostly reported as sparse case series or small case–control studies. In this review, we organize and report current evidence regarding the role of high-risk human papillomavirus, mouse mammary tumor virus, Epstein–Barr virus, cytomegalovirus, bovine leukemia virus, human polyomavirus 2, and Merkel cell polyomavirus in the pathogenesis of breast cancer.

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The role of viruses in cancer progression versus cancer treatment: A dual paradigm

Dash,

Kundu,

Kundu

2024

Life Sciences

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Epstein-Barr virus in breast carcinoma and in triple negative cases impact on clinical outcomes

Cited by 4 publications

References 54 publications

Association of Human Papilloma Virus, Cytomegalovirus, and Epstein–Barr Virus with Breast Cancer in Jordanian Women

Association of Human Papilloma Virus, Cytomegalovirus, and Epstein–Barr Virus with Breast Cancer in Jordanian Women

The Role of Oncogenic Viruses in the Pathogenesis of Sporadic Breast Cancer: A Comprehensive Review of the Current Literature

The role of viruses in cancer progression versus cancer treatment: A dual paradigm

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