Epstein-Barr virus induced acute hepatitis with hyperferritinemia: A rare presentation

Theodory, Bassam; Dopp, Meena; Swisher, Austin R.; Flores, Roberto M.; Robb, Paul M.

doi:10.1016/j.idcr.2023.e01872

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Similarly, their case also exhibited hepatitis to the same extent. 8 Serological assays are the most efficacious diagnostic tools. The heterophile antibody assays detect immunoglobulin M (IgM) antibodies specific to the Epstein-Barr virus (EBV).…”

Section: Discussion Discussionmentioning

confidence: 99%

An overlooked cause of hepatitis and thrombocytopenia with clinico-biochemical discrepancy: A case of infectious mononucleosis

DEMİRKAN,

GÜVEN

2023

DAHUDER Medical Journal

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A 22-year-old male was admitted to the outpatient clinic with fatigue, fever, and a sore throat. High transaminase levels, moderate thrombocytopenia, and elevated acute phase reactants were detected ten times. Ultrasound imaging revealed hepatosplenomegaly and a peripheral blood smear showed Downey cells. Epstein-Barr virus (EBV) infection was considered the definite diagnosis, and EBV serology was performed. His mild clinic improved to normal within days, but the patient's clinical progression and laboratory findings were incompatible. Laboratory results were on the extreme side, while the clinic was mildly deteriorating. EBV viral capsid antigen IgM was high, supporting the initial diagnosis. Biochemical normalization followed clinical improvement many days later. Clinicians should know that EBV infection may be mild, while laboratory results illustrate extreme findings.

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Section: Discussion Discussionmentioning

confidence: 99%

An overlooked cause of hepatitis and thrombocytopenia with clinico-biochemical discrepancy: A case of infectious mononucleosis

DEMİRKAN,

GÜVEN

2023

DAHUDER Medical Journal

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Epstein-Barr Acute Viral Hepatitis With Hyperferritinemia Presents as Obstructive Cholangitis

Trivedi,

Szinte,

Hasan

et al. 2024

Cureus

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Adolescent Epstein-Barr Virus Hepatitis Without Typical Mononucleosis Symptoms and Gilbert’s Syndrome: A Case Report

Dennis,

Hasan,

Jackson

et al. 2024

Cureus

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Epstein-Barr virus (EBV) is one of the most common infections worldwide that presents with a multitude of symptoms such as lymphadenopathy, fever, and malaise and has associations with Hodgkin's lymphoma. EBV can cause elevations in transaminase values and hyperbilirubinemia; however, EBV will rarely cause hepatitis with cholestatic features. Here we report a case of a 15-year-old male with a past medical history of potential Gilbert’s syndrome who presented with jaundice, scleral icterus, mild abdominal pain, and low-grade fever. Further work-up revealed elevated transaminase values, abnormal coagulation studies, and thrombocytopenia. The patient was monitored and diagnosed with EBV hepatitis, then treated with supportive therapy and IV vitamin K for the resolution of abnormal coagulopathy. The following report presents a patient with EBV hepatitis without the typical presentation of EBV, with a process for diagnosing and managing patients.

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Epstein-Barr virus induced acute hepatitis with hyperferritinemia: A rare presentation

Cited by 3 publications

References 14 publications

An overlooked cause of hepatitis and thrombocytopenia with clinico-biochemical discrepancy: A case of infectious mononucleosis

An overlooked cause of hepatitis and thrombocytopenia with clinico-biochemical discrepancy: A case of infectious mononucleosis

Epstein-Barr Acute Viral Hepatitis With Hyperferritinemia Presents as Obstructive Cholangitis

Adolescent Epstein-Barr Virus Hepatitis Without Typical Mononucleosis Symptoms and Gilbert’s Syndrome: A Case Report

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