Epstein-Barr-Virus-Induced Oncogenesis in Immune-Deficient Individuals

Purtilo, DavidT.

doi:10.1016/s0140-6736(80)90792-8

Cited by 192 publications

(57 citation statements)

References 26 publications

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“…Males affected with the X-linked lymphoproliferative syndrome are uncommonly susceptible to infectious mononucleosis, and this disease often has a fatal course in such patients (Purtilo, 1980). Interestingly enough, these males frequently have deficient natural killer cell activity (Sullivan et al, 1980).…”

Section: Recombinant Inbred Strains and The Congenic B6-c-h-28c-lf-p mentioning

confidence: 99%

An X-linked Locus Influences the Amount of Circulating Interferon Induced in the Mouse by Herpes Simplex Virus Type 1

Zawatzky

Kirchner

DeMaeyer-Guignard

et al. 1982

Journal of General Virology

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SUMMARYProduction of circulating interferon (IFN) was measured in inbred mouse strains following intravenous injection of herpes simplex virus type 1 (HSV-1). IFN titres reached maximal levels 2 to 3 h after injection of virus and a 10-fold difference was found between C57BL/6 mice and BALB/c, as high and low producers respectively. Mendelian analysis revealed that HSV-induced IFN production is governed by several loci, one of which is X-linked. The strain distribution pattern obtained from results in recombinant inbred lines and the results obtained in the congenic B6-C-H-28c-If-11 strain furthermore indicated an absence of close linkage to If-1. It is concluded that the levels of HSV-induced early IFN production are influenced by several autosomal loci and one X-linked locus.

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Section: Recombinant Inbred Strains and The Congenic B6-c-h-28c-lf-p mentioning

confidence: 99%

An X-linked Locus Influences the Amount of Circulating Interferon Induced in the Mouse by Herpes Simplex Virus Type 1

Zawatzky

Kirchner

DeMaeyer-Guignard

et al. 1982

Journal of General Virology

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“…However, this virus has been associated with several human malignancies, including Burkitt's lymphoma (BL), Hodgkin's disease and nasopharyngeal carcinoma (Henle et al, 1966;Gunven et al, 1970;Henle and Henle, 1973a, b). Moreover, EBV is implicated in disorders related to immunodeficiency, such as post-transplantation lymphoproliferative disorders and AIDS-related lymphomas (Purtilo, 1980;Ciobanu and Wiernik, 1986;Rooney et al, 1986;Thomas and Crawford, 1989).…”

Section: Introductionmentioning

confidence: 99%

Chromosomal rearrangements after ex vivo Epstein–Barr virus (EBV) infection of human B cells

et al. 2009

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The Epstein-Barr virus (EBV) is carried by more than 90% of the adult world population and has been implicated in several human malignancies. Its ability to induce unlimited in vitro proliferation of B cells is frequently used to generate lymphoblastoid cell lines (LCLs). In this study, we have investigated the evolution of two LCLs up to 25 weeks after EBV infection. LCLs were karyotyped once a month by spectral karyotyping (SKY). LCLs but not mitogen-activated B cells showed evidence of DNA damage and DNA damage response within the first 2 weeks. After 4 weeks, the former, but not the latter, showed a high level of non-clonal structural aberrations, mainly deletions, fragments, dicentric chromosomes and unbalanced translocations. Genomic instability decreased thereafter over time. Nonrandom aneuploidy 12 weeks after infection showed clonal evolution in culture. After 25 weeks post-infection, most cells exhibited karyotypic stability. Chromosomal aberrations were compatible with telomere dysfunction, although in the absence of telomere shortening. The telomere capping protein TRF2 was partially displaced from telomeres in EBV-infected cells, suggesting an EBVmediated uncapping problem. In conclusion, this study suggests that DNA damage and telomere dysfunction contribute to EBV-related chromosomal instability in early LCLs.

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“…HPV 16/18 has already been reported in squamous cell carcinoma and Rowen's disease [5,9,16,21,29] in immunocompetent subjects and transplant patients [22,27]. It has also been found in warts of transplant patients [5].…”

Section: Discussionmentioning

confidence: 96%

“…The frequency of carcinoma in graft recipients is three times that in the general population [13,19,22]. The frequency of skin cancer in these patients is 20-30 times as high [lo].…”

Section: Introductionmentioning

confidence: 99%

Frequency of mucosal HPV DNA detection (types 6/11, 16/18, 31/35/51) in skin lesions of renal transplant patients

Mansat-Krzyzanowska¹,

Dantal

Hourmant

et al. 1997

Transplant Int

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Human papillomaviruses (HPV) probably play a role in the development of skin cancer in renal transplant recipients. Since some mucosal HPV are strongly related to cervical cancer, we compared the frequency of HPV DNA detection (mucosal types 6/1 I , 16/18, and 31/ 33/51) in skin cancer of renal transplant recipients (21 lesions) with that in normal subjects without immunodeficiency (21 lesions) and studied the frequency of these same HPV in benign lesions of renal transplant recipients (34 lesions) and normal subjects (30 lesions). An in situ hybridization technique employing cold biotin probes was used. HPV DNA was not significantly ( P = 0.09.5) more frequent in malignant skin cancer in renal transplant recipients (42.9 %) than in normal subjects (19.04 %), but was significantly more frequent in benign lesions in renal transplant recipients (32.4 YO) than in controls (10 YO; P < 0.0.5). These results on a limited number of skin lesions do not allow one to confirm the predominant role of mucosal HPV in the development of skin cancer in renal transplant recipients. HPV interaction with other factors related to the immunosuppressive state may play a role.

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Epstein-Barr-Virus-Induced Oncogenesis in Immune-Deficient Individuals

Cited by 192 publications

References 26 publications

An X-linked Locus Influences the Amount of Circulating Interferon Induced in the Mouse by Herpes Simplex Virus Type 1

An X-linked Locus Influences the Amount of Circulating Interferon Induced in the Mouse by Herpes Simplex Virus Type 1

Chromosomal rearrangements after ex vivo Epstein–Barr virus (EBV) infection of human B cells

Frequency of mucosal HPV DNA detection (types 6/11, 16/18, 31/35/51) in skin lesions of renal transplant patients

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